MAP2K4 Proteine (MAP2K4)

Mitogen-Activated Protein Kinase Kinase 4 Proteine (MAP2K4)
Auf finden Sie aktuell 11 Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP2K4 Antikörper (327) und MAP2K4 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 365 MAP2K4 Produkte verfügbar.
2, 142758_at, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, CG9738, CT27508, CT38386, D-MKK4, DmelCG12798, Dmel\\CG9738, dMkk4, F19C24.26, F19C24_26, hep, JNKK, JNKK1, Jnkk2, map2k4, MAP KINASE KINASE 4, MAPKK4, Mapkk7, MEK4, Mek7, mitogen-activated protein kinase kinase 4, MKK4, MKK4A-l, Mkk7, Mpk4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SEK1/MKK4, Serk1, SKK1, xmek2, zgc:136500
alle Proteine anzeigen Gen GeneID UniProt
Ratte MAP2K4 MAP2K4 287398  
MAP2K4 6416 P45985
MAP2K4 26398 P47809

Weitere Synonyme anzeigen

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Am meisten referenzierte MAP2K4 Proteine

  1. Mouse (Murine) MAP2K4 Protein expressed in Baculovirus infected Insect Cells - ABIN2008094 : Bouzakri, Zierath: MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. in The Journal of biological chemistry 2007 (PubMed)

Weitere Proteine zu MAP2K4 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Interaktionspartner

  1. in Drosophila both MAPKKs, Hep/Mkk7 (zeige MAP2K7 Proteine) and Mkk4, are required to induce JNK (zeige MAPK8 Proteine) upon TNF (zeige TNF Proteine) or pro-inflammatory stimulation

Human Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Interaktionspartner

  1. MKK4 activates non-canonical NFkappaB (zeige NFKB1 Proteine) signaling by promoting NFkappaB2-p100 (zeige CUX1 Proteine) processing.

  2. Manipulating the expression of both miR (zeige MLXIP Proteine)-222 and miR (zeige MLXIP Proteine)-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR (zeige MLXIP Proteine)-25 reduced MEK4 and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR (zeige MLXIP Proteine)-25 functioning in thyroid cells.

  3. These results suggest that ROCK may be important in IL-1 (zeige IL1A Proteine)-induced signaling through MKK4 to JNK (zeige MAPK8 Proteine) and the activation of p38 MAPK (zeige MAPK14 Proteine).

  4. Association between MKK4 promoter polymorphism and breast cancer risk in Kashmiri population

  5. In Chinese Han ischemic stroke patients rs3826392 C/A genotype carriers showed significantly higher IL-1b (zeige IL1B Proteine) serum levels.

  6. The plasma level of protein MAP2K4 was found to suggestively associate negatively with the volume of the left entorhinal cortex in asymptomatic older twins.

  7. MAP2K4 increases human prostate cancer metastasis, and prolonged over expression induces long term changes in cell signaling pathways leading to independence from p38 MAPK (zeige MAPK14 Proteine) and JNK (zeige MAPK8 Proteine).

  8. MKK4 is activated in vitro by reduced Trx (zeige VAC14 Proteine) but not oxidized Trx (zeige VAC14 Proteine) in the absence of an upstream kinase, suggesting that autophosphorylation of this protein occurs due to reduction of Cys (zeige DNAJC5 Proteine)-246 and Cys (zeige DNAJC5 Proteine)-266 by Trx (zeige VAC14 Proteine).

  9. Data suggest a genetic interaction between MAP2K4 and HLA-DRB1 (zeige HLA-DRB1 Proteine), and the importance of rs10468473 and MAP2K4 splice variants in the development of autoantibody-positive RA.

  10. knockdown of Sec8 (zeige EXOC4 Proteine) enhances the binding of JIP4 (zeige SPAG9 Proteine) to MAPK (zeige MAPK1 Proteine) kinase 4, thereby decreasing the phosphorylation of MAPK (zeige MAPK1 Proteine) kinase 4, JNK (zeige MAPK8 Proteine), and p38 (zeige CRK Proteine).

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Interaktionspartner

  1. MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 (zeige PATL2 Proteine) processing.

  2. Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 (zeige TGFB1 Proteine) signaling associated with atrial remodeling and arrhythmogenesis with age.

  3. This study provides compelling evidence for the pivotal roles of the ZPK/DLK (zeige MAP3K12 Proteine) and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates.

  4. The loss of mkk4 and mkk7 (zeige MAP2K7 Proteine) locks damaged exocrine cells in a permanently de-differentiated state.

  5. Studies identify the dual-specific kinase MKK4 as a master regulator of liver regeneration. MKK4 silencing robustly increased the regenerative capacity of hepatocytes in mouse models of liver regeneration and acute and chronic liver failure.

  6. MicroRNA-92a negatively regulates Toll (zeige TLR4 Proteine)-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase

  7. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.

  8. MKK4/7 and JNK1 (zeige MAPK8 Proteine)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.

  9. These data support a model in which MKK4 activation at the metastatic site causes a cell-cycle arrest.

  10. Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 (zeige GJA1 Proteine) reduction and couples hypertrophic signals to ventricular arrhythmogenesis.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Interaktionspartner

  1. MKK4, MKK5 (zeige MAP2K5 Proteine), MKK7 (zeige MAP2K7 Proteine), and MKK9, are responsible for the activation of MPK3 (zeige MAPK3 Proteine) and MPK6 (zeige MAPK6 Proteine) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Proteine) signaling through MKK4/5/7/9-MPK3 (zeige MAPK3 Proteine)/6 cascades.

  2. our data indicate that EDR1 physically associates with MKK4/MKK5 (zeige MAP2K5 Proteine) and negatively regulates the MAPK (zeige MAPK1 Proteine) cascade to fine-tune plant innate immunity.

  3. Results suggest that the YDA-MKK4/MKK5 (zeige MAP2K5 Proteine)-MPK3 (zeige MAPK3 Proteine)/MPK6 (zeige MAPK6 Proteine) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.

  4. MKK4 is involved in the osmotic-stress response via its regulation of MPK3 (zeige MAPK3 Proteine) activity.

  5. MKK4 is a key regulator of stomatal development and patterning.

MAP2K4 Protein Überblick

Protein Überblick

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

Alternative names and synonyms associated with MAP2K4

  • mitogen-activated protein kinase kinase 4 (map2k4)
  • MAP kinase kinase 4 (Mkk4)
  • CG12798 (CG12798)
  • mitogen activated protein kinase kinase 4 (Map2k4)
  • mitogen activated protein kinase kinase 7 (Map2k7)
  • mitogen-activated protein kinase kinase 4 (MAP2K4)
  • mitogen-activated protein kinase kinase 4 (Map2k4)
  • mitogen-activated protein kinase kinase 4 (MKK4)
  • mitogen-activated protein kinase kinase 4a (map2k4a)
  • 2 Protein
  • 142758_at Protein
  • ATMEK4 Protein
  • ATMKK4 Protein
  • CG9738 Protein
  • CT27508 Protein
  • CT38386 Protein
  • D-MKK4 Protein
  • DmelCG12798 Protein
  • Dmel\\CG9738 Protein
  • dMkk4 Protein
  • F19C24.26 Protein
  • F19C24_26 Protein
  • hep Protein
  • JNKK Protein
  • JNKK1 Protein
  • Jnkk2 Protein
  • map2k4 Protein
  • MAPKK4 Protein
  • Mapkk7 Protein
  • MEK4 Protein
  • Mek7 Protein
  • mitogen-activated protein kinase kinase 4 Protein
  • MKK4 Protein
  • MKK4A-l Protein
  • Mkk7 Protein
  • Mpk4 Protein
  • PRKMK4 Protein
  • SAPKK-1 Protein
  • SAPKK1 Protein
  • SEK1 Protein
  • SEK1/MKK4 Protein
  • Serk1 Protein
  • SKK1 Protein
  • xmek2 Protein
  • zgc:136500 Protein

Bezeichner auf Proteinebene für MAP2K4

CG9738-PA , CG9738-PB , CG9738-PC , JNK kinase 2 , Map kinase kinase 4 , Mkk4-PA , Mkk4-PB , Mkk4-PC , drosophila MAP kinase kinase 4 , CG12798 , CG12798-PA , MAP2K4delta , SAPK/ERK kinase 1 , dual specificity mitogen-activated protein kinase kinase 4 , JNK-activating kinase 2 , JNKK 2 , MAP kinase kinase 7 , MAPK/ERK kinase 7 , MAPKK 7 , MEK 7 , c-Jun N-terminal kinase kinase 2 , dual specificity mitogen-activated protein kinase kinase 7 , JNK activating kinase 1 , JNK-activated kinase 1 , JNK-activating kinase 1 , MAP kinase kinase 4 , MAPK/ERK kinase 4 , MAPKK 4 , MEK 4 , c-Jun N-terminal kinase kinase 1 , stress-activated protein kinase kinase 1 , C-JUN N-terminal kinase kinase 1 , JNK kinase 1 , JNKK 1 , SAPK/Erk/kinase 1 , mitogen activated protein kinase kinase 4, variant 1 , mitogen-activated protein kinase kinase 4 , mkk4a

100135013 Xenopus (Silurana) tropicalis
41020 Drosophila melanogaster
3355004 Drosophila melanogaster
287398 Rattus norvegicus
363855 Rattus norvegicus
6416 Homo sapiens
26398 Mus musculus
489508 Canis lupus familiaris
841591 Arabidopsis thaliana
403052 Danio rerio
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