ERK2 Proteine (MAPK1)

Bezeichnung:
Mitogen-Activated Protein Kinase 1 Proteine (MAPK1)
Auf www.antikoerper-online.de finden Sie aktuell 39 Mitogen-Activated Protein Kinase 1 (MAPK1) Proteine von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ERK2 Antikörper (366) und ERK2 Kits (53) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 476 ERK2 Produkte verfügbar.
Synonyme:
9030612K14Rik, AA407128, ATMPK1, ATMPK2, AU018647, C78273, erk, erk2, ert1, F14N23.9, F14N23_9, mapk, mapk1, mapk1a, mapk1b, mapk2, MITOGEN-ACTIVATED PROTEIN KINASE, mitogen-activated protein kinase 1, mitogen-activated protein kinase homolog 2, mpk1, p38, p40, p41, p41mapk, p42mapk, prkm1, prkm2, T30E16.13, T30E16_13, Xp42, zERK2
alle Proteine anzeigen Gen GeneID UniProt
MAPK1 5594 P28482
MAPK1 26413 P63085
MAPK1 116590 P63086

Weitere Synonyme anzeigen

ERK2 Proteine (MAPK1) nach Spezies

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Am meisten referenzierte ERK2 Proteine

  1. Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936 : Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001 (PubMed)
    Zeige alle 2 Referenzen für 2001936

  2. Human ERK2 Protein expressed in Escherichia coli (E. coli) - ABIN666923 : Hu, Xie, Onishi, Yu, Jiang, Lin, Rho, Woodard, Wang, Jeong, Long, He, Wade, Blackshaw, Qian, Zhu: Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. in Cell 2009 (PubMed)
    Zeige alle 2 Referenzen für 666923

  3. Human ERK2 Protein expressed in Wheat germ - ABIN1310256 : Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. in Nucleic acids research 2016 (PubMed)

Weitere Proteine zu ERK2 Interaktionspartnern

Arabidopsis thaliana Mitogen-Activated Protein Kinase 1 (MAPK1) Interaktionspartner

  1. MKP1 (zeige DUSP1 Proteine) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.

  2. MKP1 (zeige DUSP1 Proteine) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (zeige MAPK3 Proteine)- and MPK6 (zeige MAPK6 Proteine)-dependent manner.

  3. Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.

  4. AtMKP2, a novel MKP protein in Arabidopsis, acts upon MPK3 (zeige MAPK3 Proteine) and -6, and serves as a positive regulator of the cellular response to oxidant challenge

Cow (Bovine) Mitogen-Activated Protein Kinase 1 (MAPK1) Interaktionspartner

  1. The present results suggest that demecolcine might contribute to the activation of the Mos (zeige MOCOS Proteine)/MAPK pathway and affect spindle structure

  2. MAPK1 upregulated milk protein (zeige CSN2 Proteine) synthesis through the Stat5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) pathways.

  3. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.

  4. ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.

  5. Cyclin-dependent kinase (zeige CDK1 Proteine) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (zeige MSLN Proteine)) and MAPK, and had nearly no effect on kinase activities during maturation.

  6. Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.

  7. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  8. These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Proteine) nuclear accumulation.

  9. Role of CaMKII (zeige CAMK2G Proteine) in hydrogen peroxide activation of p38 MAPK (zeige MAPK14 Proteine)/heat shock protein 27 pathway and ERK1/2

  10. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

Zebrafish Mitogen-Activated Protein Kinase 1 (MAPK1) Interaktionspartner

  1. Excess PLAC8 promotes an unconventional ERK2-dependent EMT (zeige ITK Proteine) in colon cancer.

  2. ERK1/2-Akt1 (zeige AKT1 Proteine) crosstalk regulates arteriogenesis in mice and zebrafish.

  3. eena (zeige SH3GL1 Proteine) plays an important role in the development of the myeloid cell through activation of the ERK1 (zeige MAPK3 Proteine)/ERK2 pathway

  4. ERK1 (zeige MAPK3 Proteine) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.

  5. These results demonstrate that induction of Hsp70 (zeige HSPA1A Proteine) in response to heat stress is dependent on ERK activation in Pac2 (zeige PSMG2 Proteine) cells.

  6. Data define distinct roles for ERK1 (zeige MAPK3 Proteine) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.

Human Mitogen-Activated Protein Kinase 1 (MAPK1) Interaktionspartner

  1. Finally, the authors show that EGFR (zeige EGFR Proteine)-ERK1/2 and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 (zeige EGR1 Proteine) upregulation.

  2. findings show that endothelial MAPKs ERK (zeige EPHB2 Proteine), p38 (zeige CRK Proteine), and JNK (zeige MAPK8 Proteine) mediate diapedesis-related and diapedesis-unrelated functions of ICAM-1 (zeige ICAM1 Proteine) in cerebral and dermal microvascular endothelial cells (MVECs).

  3. RARRES2 (zeige RARRES2 Proteine) overexpression in adrenocortical carcinoma cells inhibited Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway activity by promoting beta-catenin (zeige CTNNB1 Proteine) phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase (zeige MAPK14 Proteine). Thus our study identifies RARRES2 (zeige RARRES2 Proteine) as a novel tumor suppressor for adrenocortical carcinoma, which can function through an immune-independent mechanism.

  4. the direct binding of ERalpha (zeige ESR1 Proteine)-36 to ERK2 prevents its dephosphorylation by MKP3 (zeige DUSP6 Proteine) and enhances the downstream signaling. These findings improve our understanding of the regulation of non-genomic estrogen signaling and open new avenues for personalized therapeutic approaches targeting Src (zeige SRC Proteine) or MEK (zeige MAP2K1 Proteine) in ERalpha (zeige ESR1 Proteine)-36-positive patients.

  5. a new ERK2/AP-1 (zeige FOSB Proteine)/miR (zeige MLXIP Proteine)-494/PTEN pathway that is responsible for the tumor-suppressive role of NFkappaB2 p100 (zeige CUX1 Proteine) in cellular transformation.

  6. the mitochondrial morphology of T-cell acute lymphoblastic leukemia cells were altered from elongation to fragmentation because of the extracellular signal-regulated kinase activation-mediated phosphorylation of the pro-fission factor, dynamin-related protein 1 (Drp1 (zeige DNM1L Proteine)), at residue S616.

  7. ERK2 phosphorylation is mediated by Src (zeige SRC Proteine) and Csk (zeige CSK Proteine).

  8. Aberrant expression of sema3c is correlated with poor prognosis of pancreatic ductal adenocarcinoma patients and promotes tumor growth and metastasis by activating ERK1/2 signaling pathway.

  9. Increased staining for phosphorylated ERK1/2 does not correlate to BRAF or KRAS mutations in colorectal neoplasms.

  10. Mutations of MAP2K1 (zeige MAP2K1 Proteine) are frequent in pediatric-type follicular lymphoma and result in ERK1 (zeige MAPK3 Proteine)/ERK2 pathway activation.

Mouse (Murine) Mitogen-Activated Protein Kinase 1 (MAPK1) Interaktionspartner

  1. Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.

  2. Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.

  3. the cooperative role of TLR9 (zeige TLR9 Proteine) with TLR2 or TLR6 (zeige TLR6 Proteine) receptors in sensing Brucella, was determined.

  4. tau overexpression mediates the excitatory toxicity induced by E-NMDAR (zeige GRIN1 Proteine) activation through inhibiting ERK (zeige EPHB2 Proteine) phosphorylation.

  5. retinoschisin (zeige RS1 Proteine) is a novel regulator of MAP kinase signalling and exerts an anti-apoptotic effect on retinal cells.

  6. Postnatal chondrocyte-specific deletion of Hdac3 (zeige HDAC3 Proteine) with an inducible Col2a1 (zeige COL2A1 Proteine)-Cre caused premature production of pErk1/2 and Mmp13 (zeige MMP13 Proteine) in the growth plate.

  7. The progress of neurogenesis depended on sustained ERK phosphorylation and resulted in ERK1/2 translocation to the nucleus.

  8. The kinase TPL2 (zeige MAP3K8 Proteine) activates ERK (zeige EPHB2 Proteine) and p38 (zeige CRK Proteine) signaling to promote neutrophilic inflammation

  9. Low frequency pulsed electromagnetic field (PEMF) induced the activation of extracellular signal-regulated kinases ERK1/2, and the phosphorylation level of ERK1/2 increased after 15 min when exposed to PEMF.

  10. Our results will help understand the mechanism of ETV4 (zeige ETV4 Proteine) overexpression in CRC patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.

Pig (Porcine) Mitogen-Activated Protein Kinase 1 (MAPK1) Interaktionspartner

  1. Agonist stimulation of vascular smooth muscle increases PKC (zeige FYN Proteine) activity, which, in turn, increases MKP-1 (zeige DUSP1 Proteine) activity and maintains MAPK1 activity at submaximal values.

  2. sub-vasomotor concentration of ET-1 (zeige EDN1 Proteine) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (zeige MAPK14 Proteine) kinase-mediated production of superoxide from NADPH oxidase (zeige NOX1 Proteine) following ETA receptor activation

  3. Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.

  4. This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.

  5. CSF2 (zeige CSF2 Proteine) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.

  6. PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (zeige PPARG Proteine) phosphorylation.

  7. Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Proteine)/2 dependent.

  8. The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.

  9. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

  10. Data show that treatment with GH or IGF-I (zeige IGF1 Proteine) reduced leptin receptor (zeige LEPR Proteine) expression, and increased Phosphorylation of ERK1/2 in response to acute leptin (zeige LEP Proteine).

Xenopus laevis Mitogen-Activated Protein Kinase 1 (MAPK1) Interaktionspartner

  1. The reciprocal feedback observed between MPF (zeige MSLN Proteine) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.

ERK2 (MAPK1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Alternative names and synonyms associated with ERK2 (MAPK1)

  • mitogen-activated protein kinase 1 (ATMPK1)
  • mitogen-activated protein kinase 1 (MPK1)
  • mitogen-activated protein kinase 2 (MPK2)
  • mitogen-activated protein kinase 1 (MAPK1)
  • mitogen-activated protein kinase 1 (mapk1)
  • mitogen-activated protein kinase 1 (Mapk1)
  • mitogen-activated protein kinase 1 (PfMAP1)
  • mitogen-activated protein kinase 1 (PVX_084965)
  • mitogen activated protein kinase 1 (Mapk1)
  • mitogen-activated protein kinase 1 (Tsp_01601)
  • mitogen-activated protein kinase 1 (mapk1-b)
  • mitogen-activated protein kinase 1 (mapk1-a)
  • 9030612K14Rik Protein
  • AA407128 Protein
  • ATMPK1 Protein
  • ATMPK2 Protein
  • AU018647 Protein
  • C78273 Protein
  • erk Protein
  • erk2 Protein
  • ert1 Protein
  • F14N23.9 Protein
  • F14N23_9 Protein
  • mapk Protein
  • mapk1 Protein
  • mapk1a Protein
  • mapk1b Protein
  • mapk2 Protein
  • MITOGEN-ACTIVATED PROTEIN KINASE Protein
  • mitogen-activated protein kinase 1 Protein
  • mitogen-activated protein kinase homolog 2 Protein
  • mpk1 Protein
  • p38 Protein
  • p40 Protein
  • p41 Protein
  • p41mapk Protein
  • p42mapk Protein
  • prkm1 Protein
  • prkm2 Protein
  • T30E16.13 Protein
  • T30E16_13 Protein
  • Xp42 Protein
  • zERK2 Protein

Bezeichner auf Proteinebene für MAPK1

mitogen-activated protein kinase 1 , ERK-2 , ERT1 , MAP kinase 1 , MAP kinase 2 , MAPK 1 , MAPK 2 , extracellular signal-regulated kinase 2 , mitogen-activated protein kinase 2 , p42-MAPK , ERK2 , MAP kinase isoform p42 , protein tyrosine kinase ERK2 , mitogen activated protein kinase 1 , extracellular-signal-regulated kinase 2 , extracellular signal-regulated kinase-2 , MAP kinase , mitogen-activated protein kinase 1b , myelin basic protein kinase-like protein , mitogen-activated protein kinase 1a

GENE ID SPEZIES
9328617 Arabidopsis lyrata subsp. lyrata
837559 Arabidopsis thaliana
842248 Arabidopsis thaliana
327672 Bos taurus
477575 Canis lupus familiaris
360144 Danio rerio
373953 Gallus gallus
5594 Homo sapiens
26413 Mus musculus
811876 Plasmodium falciparum 3D7
5475967 Plasmodium vivax Sal-1
116590 Rattus norvegicus
100153927 Sus scrofa
10911653 Trichinella spiralis
549881 Xenopus (Silurana) tropicalis
397785 Xenopus laevis
398985 Xenopus laevis
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