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Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936
Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human ERK2 Protein expressed in Wheat germ - ABIN1310256
Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. in Nucleic acids research 2016
MKP1 (zeige DUSP1 Proteine) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (zeige DUSP1 Proteine) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (zeige MAPK3 Proteine)- and MPK6 (zeige MAPK6 Proteine)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
AtMKP2, a novel MKP protein in Arabidopsis, acts upon MPK3 (zeige MAPK3 Proteine) and -6, and serves as a positive regulator of the cellular response to oxidant challenge
The present results suggest that demecolcine might contribute to the activation of the Mos (zeige MOCOS Proteine)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (zeige CSN2 Proteine) synthesis through the Stat5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (zeige CDK1 Proteine) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (zeige MSLN Proteine)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Proteine) nuclear accumulation.
Role of CaMKII (zeige CAMK2G Proteine) in hydrogen peroxide activation of p38 MAPK (zeige MAPK14 Proteine)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (zeige ITK Proteine) in colon cancer.
ERK1/2-Akt1 (zeige AKT1 Proteine) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Proteine) plays an important role in the development of the myeloid cell through activation of the ERK1 (zeige MAPK3 Proteine)/ERK2 pathway
ERK1 (zeige MAPK3 Proteine) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Proteine) in response to heat stress is dependent on ERK activation in Pac2 (zeige PSMG2 Proteine) cells.
Data define distinct roles for ERK1 (zeige MAPK3 Proteine) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
in diffuse malignant peritoneal mesothelioma (DMPM) persistent activation of ERK1/2 and AKT (zeige AKT1 Proteine) in miR (zeige MLXIP Proteine)-34a-reconstituted cells was found to counteract the antiproliferative and proapoptotic effects of miRNA, yet not affecting its anti-invasive activity
High p38 MAPK (zeige MAPK14 Proteine) expression is associated with cisplatin resistance in lung cancer.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (zeige PRKAA1 Proteine)/p38 MAPK (zeige MAPK14 Proteine)-ERK3 (zeige MAPK4 Proteine)/mTORC1 pathways.
These studies revealed that impulsive behavior driven by inhibition of the A2AR (zeige ADORA2A Proteine) is accompanied by increased neuroblast proliferation in the hippocampus.
Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors.
these findings suggest an important role of GPR160 (zeige GPR160 Proteine) in regulating the entry of BCG (zeige SLC11A1 Proteine) into macrophages by targeting the ERK (zeige EPHB2 Proteine) signaling pathway.
The results of this study suggest for the first time that cadmium induces MUC8 expression via TLR4 (zeige TLR4 Proteine)-mediated ERK1/2 and p38 MAPK (zeige MAPK14 Proteine) signaling pathway in human airway epithelial cells
Tumor-associated mutations spatially clustered in two ERK2 effector-recruitment domains yet produced mutants with opposite phenotypes.
High ERK2 expression is associated with Ovarian Cancer.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 (zeige MAPK3 Proteine) or Erk2 significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (zeige CD44 Proteine) expression, and increased CD44 (zeige CD44 Proteine) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (zeige ICAM1 Proteine) and VCAM-1 (zeige VCAM1 Proteine) by activating the ERK1/2 pathway, resulting in the expression of ETB (zeige EDNRB Proteine) receptors and the enhancement of contractile function in vascular smooth muscle.
These results indicate a crucial role of the Rapgef2 (zeige RAPGEF2 Proteine)-Rap1A (zeige RAP1A Proteine)-ERK (zeige EPHB2 Proteine)-c-jun (zeige JUN Proteine) pathway in regulation of the AJ formation in RGCs.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4 (zeige NOX4 Proteine)/ROS (zeige ROS1 Proteine)-MAPK signalling pathway.
MAPK3 (zeige MAPK3 Proteine)/1 participates in primordial follicle activation through mTORC1-KITL (zeige KITLG Proteine) signaling.
The purpose of this study was to investigate mechanisms that govern the regulation of Npnt (zeige NPNT Proteine) gene expression by IL-1beta (zeige IL1B Proteine) in osteoblasts.
The results of this study suggested that Erk2 activation in astrocytes plays a crucial role in aggravating demyelinating inflammation by inducing inflammatory mediators and gliosis.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (zeige FYN Proteine) activity, which, in turn, increases MKP-1 (zeige DUSP1 Proteine) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (zeige EDN1 Proteine) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (zeige MAPK14 Proteine) kinase-mediated production of superoxide from NADPH oxidase (zeige NOX1 Proteine) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Proteine) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (zeige PPARG Proteine) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Proteine)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (zeige MSLN Proteine) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
mitogen-activated protein kinase 1
, MAP kinase 1
, MAP kinase 2
, MAPK 1
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, MAP kinase isoform p42
, protein tyrosine kinase ERK2
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, extracellular signal-regulated kinase-2
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a