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Human HSP90 Protein expressed in Insect cells (Sf9) - ABIN809771
Burress, Taylor, Banerjee, Tatulian, Teter: Co- and post-translocation roles for HSP90 in cholera Intoxication. in The Journal of biological chemistry 2014
FKBP51 (zeige FKBP4 Proteine) is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (zeige FKBP4 Proteine) (but not FKBP52 (zeige FKBP4 Proteine)) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria.
High HSP90 expression is associated with Colorectal Cancers.
High HSP90 expression is associated with prostate cancer.
Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)
Data show that pyruvate kinase M2 (PKM2) directly interacted with mutant growth factor receptor (zeige RYK Proteine) (EGFR (zeige EGFR Proteine)) and heat-shock protein 90 (HSP90), and thus stabilized EGFR (zeige EGFR Proteine) by maintaining its binding with HSP90 and co-chaperones.
Binding of FM807 to the N-terminus of Hsp90 disrupted Hsp90/client complexes, resulting in degradation of the Hsp90 client protein EGFR (zeige EGFR Proteine) and inhibition of the downstream pathway.
Conventional as well as scaled molecular dynamics simulations further demonstrate that citrullination of selected Arg residues leads to progressive disruption of HSP90 tertiary structure, promoting exposure of R502/R510 to PAD modification and subsequent autoantibody binding.
SYK (zeige SYK Proteine) is an HSP90 client protein, and B-cell receptor signaling-dependent phosphorylation of HSP90 on Y197 is required for this interaction. HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling.
There is overwhelming evidence that molecular chaperones such as Hsp27 (zeige HSPB1 Proteine), Hsp70 (zeige HSP70 Proteine) and Hsp90 are expressed at elevated levels in a wide range of cancers by stabilizing the mutated neoplasm proteins. (Review)
Data indicate a chaperone function of nicotinamide mononucleotide adenylyl transferase (zeige NMNAT1 Proteine) 2 (NMNAT2 (zeige NMNAT2 Proteine)), independent from its enzymatic activity, and NMNAT2 (zeige NMNAT2 Proteine) complexes with heat shock protein 90 (HSP90) to refold aggregated protein substrates.
DAF-21 Ienterd this protein as newentry study explores the role and contribution of MAP Kinase pathway and its regulator protein DAF-21 involvement in the immunity against opportunistic pathogen P. mirabilis infection
We demonstrate that while DAF-16/FOXO is dispensable, the age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone
We found that HLH-1-dependent myogenic conversion specifically induced the expression of putative HLH-1-regulated chaperones in differentiating muscle cells. Moreover, disrupting the putative HLH-1-binding sites on ubiquitously expressed daf-21(Hsp90) and muscle-enriched hsp-12.2(sHsp) promoters abolished their myogenic-dependent expressio
The activity of protein phosphatase 5 towards native clients, such as glucocorticoid receptor (zeige NR3C1 Proteine), is modulated by the middle- and C-terminal domains of Hsp90.
Suppression of misfolding in muscle cells is achieved not only by enhanced expression of HSP90 in muscle cells but also by elevated expression of HSP90 (Daf-21) in intestine or neuronal cells. This cell-nonautonomous control of HSP90 expression relies upon transcriptional feedback between somatic tissues that is regulated by the FoxA transcription factor PHA-4.
Hsp90 (DAF-21) appears to participate in the maintenance of muscle structures as a transiently associated diffusible factor
DAF-21 indirectly regulates the meiotic prophase/metaphase transition during oocyte development by ensuring the normal function of WEE (zeige WEE1 Proteine)-1.3.
PA28 is likely to function in collaboration with Hsp90.
Escargot and Scratch regulate neural commitment by antagonizing Notch (zeige NOTCH1 Proteine) activity in Drosophila sensory organs
Nup358 facilitates JH-induced Met nuclear transport in a manner dependent on importin beta (zeige KPNB1 Proteine) and Hsp83.
We show that while Hsp70 or Hsp83 expression under normal or stress conditions was not affected by AR feeding, Hsp27 levels were elevated in AR-fed wild-type control as well as heat-shocked larvae
The results revealed that the high-fat diet augmented the rate of lipid peroxidation and SOD (zeige SOD2 Proteine) and CAT activity and induced a higher expression of HSP83 and MPK2 (zeige MAPK1 Proteine) mRNA.
Hsp83 facilitates methoprene-tolerant nuclear import to modulate juvenile hormone signaling.
Interaction of Spag with both Hsp70 and Hsp90 suggests a model whereby R2TP would accompany clients from Hsp70 to Hsp90 to facilitate their assembly into macromolecular complexes.
Our results reveal that Hsp83 plays a heretofore unappreciated role in promoting APC (zeige APC Proteine)/C function during cell cycle exit and suggest a mechanism by which Hsp90 inhibition could promote genomic instability and carcinogenesis
Using computational and biochemical analyses, study find that Hsp90 maintains and optimizes RNA polymerase II pausing via stabilization of the negative elongation factor (zeige RDBP Proteine) complex.
Data suggest that that an Sgt1 (zeige SUGT1 Proteine)/Hsp90-LKB1 (zeige STK11 Proteine)-AMPK (zeige GRK4 Proteine) pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.
Piwi (zeige PIWIL1 Proteine) functions in Hsp90-mediated suppression of phenotypic variation
Fusion of human SGT1 (zeige SUGT1 Proteine) (hSGT1 (zeige ECD Proteine)) to NOD1 (zeige NOD1 Proteine) LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha (zeige HSP90AA2 Proteine).
The major capsid protein of the mouse polyomavirus VP1 binds microtubules, HSP90, promotes their acetylation and blocks the host cell cycle.
Artificially maintaining Hsp90alpha (zeige HSP90AA2 Proteine) or knocking down Aarsd1L expression interferes with the differentiation of C2C12 myotubes.
Immune-mediated destruction of ovarian follicles associated with the presence of HSP90 antibodies.
identify that Hsp90alpha (zeige HSP90AA2 Proteine) at the transition neck region represents a signalling platform on which IRS-1 (zeige IRS1 Proteine) interacts with intracellular downstream signalling molecules involved in IGF-1 (zeige IGF1 Proteine) receptor signalling.
The study demonstrated that HSP90alpha plays an important role in the biogenesis of fetal PIWI-interacting RNAs (piRNA), which act against the transposon activities, in mouse male germ cells.
Data show that the heat shock protein 90 (HSP90) isoforms HSP90AA1 (zeige HSP90AA1 Proteine) and HSP90AB1 (zeige HSP90AB1 Proteine) are responsible for maintaining proper cellular levels of BMAL1 (zeige ARNTL Proteine) protein.
deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation
study identified the essential role of Hsp90 in iNOS (zeige NOS2 Proteine) gene transactivation
Hsp90alpha (zeige HSP90AA2 Proteine) may be required to maintain and to activate these regulators and/or to disassemble the synaptonemal complex that holds homologous chromosomes together
This study firstly found that host chaperone heat shock protein 90 (Hsp90) had a positive regulatory effect on the porcine circovirus type 2 infection cycle in vitro.
Feed intake remains low whereas respiratory frequency and body temperature remain higher and expression of HSP90, CAT1 (zeige SLC7A1 Proteine), SGLT1 (zeige SLC5A1 Proteine) and GLUT4 (zeige SLC2A4 Proteine) increases in some tissues in pigs under chronic heat stress conditions.
HSP90AA1 (zeige HSP90AA1 Proteine) sperm content and the prediction of the boar ejaculate freezability.
Hsp90 is a modulator of eNOS (zeige NOS3 Proteine) activity and vascular reactivity in the newborn piglet pulmonary circulation
Apo (zeige C9orf3 Proteine)-Hsp90 is in a conformational equilibrium between two open states that have never been described previously.
Findings indicate an essential role for Hsp90 in nongenomic estrogen signaling in coronary artery smooth muscle cells.
Mapped six genes (EIF4G3 (zeige EIF4G3 Proteine), HSP90 (zeige HSP90AB1 Proteine), RBBP6 (zeige RBBP6 Proteine), IL8 (zeige IL8 Proteine), TERT (zeige TERT Proteine), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
Hsp90 (zeige HSP90AB1 Proteine) is involved in opposing signaling pathways of cartilage homeostasis and catabolic responses are more sensitive to Hsp90 (zeige HSP90AB1 Proteine) inhibition than are anabolic responses.
Data from Xenopus laevis embryo suggest hsp90alpha (zeige HSP90AA2 Proteine) and hsp90Beta (zeige HSP90AB1 Proteine) genes are conserved among vertebrates, and are differentially regulated in a tissue, stress, and development stage-specific manner. Hspalpha may play a role in myogenesis.
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.
, epididymis luminal secretory protein 52
, heat shock 86 kDa
, heat shock 90kD protein 1, alpha
, heat shock 90kD protein 1, alpha-like 4
, heat shock 90kD protein, alpha-like 4
, heat shock 90kDa protein 1, alpha
, heat shock protein HSP 90-alpha
, renal carcinoma antigen NY-REN-38
, heat shock protein Hsp90
, heat shock protein 90
, Heat Shock Protein 90
, heat shock protein 83
, enhancer of sevenless 3A
, enhancer of seven in absentia 2
, heat shock protein 1, alpha
, heat shock protein 86
, heat shock protein 90kDa alpha (cytosolic), class A member 1
, heat shock protein, 1
, heat shock protein, 86 kDa 1
, heat shock protein, 89 kDa
, tumor-specific transplantation 86 kDa antigen
, 90-kDa heat shock protein
, Heat shock protein HSP 90-beta-like protein
, heat shock protein HSP 90-beta
, hsp90 alpha
, heat shock protein-90