CENPJ Proteine (CENPJ)

Centromere Protein J Proteine (CENPJ)
Auf www.antikoerper-online.de finden Sie aktuell 6 Centromere Protein J (CENPJ) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CENPJ Antikörper (39) und CENPJ Kits (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 62 CENPJ Produkte verfügbar.
4932437H03Rik, BM032, CENP-J, CENPJ, CPAP, fi46g11, Gm81, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4, si:dkey-46k9.9, wu:fi46g11
alle Proteine anzeigen Gen GeneID UniProt
Ratte CENPJ CENPJ 305909  
CENPJ 55835 Q9HC77
CENPJ 219103 Q569L8

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Weitere Proteine zu CENPJ Interaktionspartnern

Zebrafish Centromere Protein J (CENPJ) Interaktionspartner

  1. Data suggest that the single G-box domain (that appears to fold into 14-20 antiparallel beta-strands) of cenpj has stable but dynamic structure; CRAP forms multimers (in solution and in crystals) of elongated fibrils similar to amyloid fibrils. [REVIEW]

  2. CPAP acts as a horizontal "strut" that joins the centriolar scaffold with microtubules, whereas G-box domains form perpendicular connections.

Human Centromere Protein J (CENPJ) Interaktionspartner

  1. CPAP-S467D protein has a low affinity for microtubule binding but a high affinity for pericentriolar material proteins.

  2. CPAP promotes timely cilium disassembly to maintain neural progenitor pool. CPAP mutation causes Seckel syndrome with microcephaly.

  3. Data suggest that the single G-box domain (that appears to fold into 14-20 antiparallel beta-strands) of CENPJ has stable but dynamic structure; CRAP forms multimers (in solution and in crystals) of elongated fibrils similar to amyloid fibrils. [REVIEW]

  4. Centrobin plays a role in the stability and centriole elongation function of CPAP and limits the centriole length.

  5. studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP-STIL interaction constitutes a conserved key step in centriole biogenesis

  6. The results showed a human-specific hypomethylation in the 5' UTR of CENPJ in the brain, where methylation levels among humans are only about one-third of those found among nonhuman primates.

  7. Centrobin-CPAP interaction is critical for the recruitment of CPAP to procentrioles to promote the elongation of daughter centrioles and for the persistence of CPAP on preexisting mother centrioles.

  8. CPAP depletion results in asymmetric spindle poles with uneven distribution of pericentriolar material.

  9. Sas-4 acts as a vehicle to tether PCM (zeige PCMT1 Proteine) complexes to centrioles independent of its well-known role in centriole duplication

  10. CEP120 associates with SPICE1 and CPAP, and depletion of any of these proteins results in short procentrioles. Furthermore, CEP120 or CPAP overexpression results in excessive centriole elongation, a process dependent on CEP120, SPICE1, and CPAP.

Mouse (Murine) Centromere Protein J (CENPJ) Interaktionspartner

  1. CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 (zeige ASCL1 Proteine).

  2. Sas4-/- mutants lack primary cilia and therefore cannot respond to Hedgehog (zeige SHH Proteine) signals, but other developmental signaling pathways are normal in the mutants.

  3. we have developed a mouse (Cenpj(tm/tm (zeige THBD Proteine))) that recapitulates many of the clinical features of Seckel syndrome, thus providing clear confirmation that specific mutations of CENPJ can cause Seckel syndrome.

CENPJ Protein Überblick

Protein Überblick

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CENPJ

  • centromere protein J (Cenpj)
  • centromere protein J (CENPJ)
  • centromere protein J (cenpj)
  • 4932437H03Rik Protein
  • BM032 Protein
  • CENP-J Protein
  • CENPJ Protein
  • CPAP Protein
  • fi46g11 Protein
  • Gm81 Protein
  • LAP Protein
  • LIP1 Protein
  • MCPH6 Protein
  • Sas-4 Protein
  • SASS4 Protein
  • SCKL4 Protein
  • si:dkey-46k9.9 Protein
  • wu:fi46g11 Protein

Bezeichner auf Proteinebene für Centromere Protein J Proteine (CENPJ)

centromere protein J , LAG-3-associated protein , LYST-interacting protein 1 , LYST-interacting protein LIP1 , LYST-interacting protein LIP7 , centrosomal P4.1-associated protein , CENP-J

305909 Rattus norvegicus
418960 Gallus gallus
486055 Canis lupus familiaris
613543 Bos taurus
721498 Macaca mulatta
568957 Danio rerio
100049819 Equus caballus
55835 Homo sapiens
219103 Mus musculus
467235 Pan troglodytes
101119996 Ovis aries
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