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Exacerbating chromosome missegregation in CENP-E+/- mice by reducing levels of another mitotic checkpoint component (zeige BUB3 ELISA Kits), Mad2 (zeige MXI1 ELISA Kits), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
CENP-E stabilises BubR1 (zeige BUB1B ELISA Kits), thereby impacting meiosis I progression, and mediates bi-orientation by promoting kinetochore reorientation and preventing chromosomal drift towards the poles.
results suggest that CENP-E is implicated in the spindle checkpoint, and in chromosome alignment, during the two meiotic divisions in vertebrate males
Deletion of the mouse gene CENP-E causes unstable kinetochore-microtubule capture and chromosomal instability. (CENP-E)
Shugoshin 2 is necessary for the loading of MCAK (zeige KIF2C ELISA Kits) at the inner centromere, but is dispensable for the loading of the outer kinetochore proteins BubR1 (zeige BUB1B ELISA Kits) and CENP-E.
CENPE was regulated by the co-binding of LSD1 (zeige KDM1A ELISA Kits) and AR to its promoter, which was associated with loss of RB1 (zeige RB1 ELISA Kits) in CRPC.
these results support a novel function of XAB2 (zeige XAB2 ELISA Kits) in mitotic cell cycle regulation, which is partially mediated by transcription regulation on CENPE.
CTCF (zeige CTCF ELISA Kits) helps recruit CENP-E to the centromere during mitosis and that it may do so through a structure stabilized by the CTCF (zeige CTCF ELISA Kits)/CENP-E complex.
Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.
CENP-Q (zeige CENPQ ELISA Kits) - a subunit of the CENP-O (zeige CENPO ELISA Kits) complex (comprising CENP-O (zeige CENPO ELISA Kits), CENP-P (zeige CENPP ELISA Kits), CENP-Q (zeige CENPQ ELISA Kits) and CENP-U (zeige MLF1IP ELISA Kits)) that targets polo-like kinase (Plk1 (zeige PLK1 ELISA Kits)) to kinetochores - is also required for the recruitment of CENP-E to kinetochores.
CENP-E-driven chromosome congression is guided by microtubule detyrosination.
CENP-E expression is highest in basal-like subtype among breast cancer patients.
An unexpected role of CENP-E elongated stalk in ensuring stability of kinetochore-microtubule attachments during chromosome congression and segregation.
dynein and CENP-E at kinetochores drive congression of peripheral polar chromosomes by preventing arm-ejection forces mediated by chromokinesins from working in the wrong direction.
Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism.
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.
centromere protein E, 312kDa
, centromere protein E - 312kD
, centromere-associated protein E
, N-7 kinesin
, centromere autoantigen E
, centromeric protein E
, kinesin 10
, kinesin superfamily protein 10
, motor domain of KIF10
, Centromere autoantigen E (312kD)
, kinesin family member 10
, kinesin-related protein CENPE
, protein phosphatase 1, regulatory subunit 61