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IL13 (zeige IL13 Proteine) AA of rs20541 and STAT4 TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 (zeige IL13 Proteine) AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 TT did not respond to high-dose ICSs.
STAT4 mRNA expression was significantly correlated with IFNG (zeige IFNG Proteine) mRNA expression.
findings demonstrate that variants in STAT4 play a critical role in HBV infection and clearance in the Chinese Han population.
STAT4 rs7574865G/T polymorphism is associated with rheumatoid arthritis and systemic lupus erythematosus in Mexican women
Results found that activated STAT4 was overexpressed in epithelial cells of ovarian cancer and provide evidence that it promotes ovarian cancer metastasis via tumor-derived Wnt7a (zeige WNT7A Proteine)-induced activation of cancer-associated fibroblasts.
STAT4 rs7574865 gene polymorphism is associated with the susceptibility of primary biliary cirrhosis in the Han population of Jiangsu province.
The findings results confirm the important role of STAT4 gene in the predisposition to Systemic sclerosis and its phenotypes, such as the presence of Interstitial Lung disease , cardiac injury , and seropositivity for anti-topoisomerase I (zeige TOP1 Proteine) antibodies in the Russian population.
results show specific and dominant contribution of STAT4 in the hematopoietic compartment to metabolic health and inflammation in diet-induced obesity.
reported that SNPs in STAT4, PTPN2 (zeige PTPN2 Proteine), PSORS1C1 (zeige PSORS1C1 Proteine), and TRAF3IP2 (zeige TRAF3IP2 Proteine) are associated with response to TNF (zeige TNF Proteine)-i treatment in RA patients; however, these findings should be validated in a larger population
This is the first demonstration of STAT4 acting as a transcriptional repressor in response to IFN-alpha (zeige IFNA Proteine)/beta signaling and highlights the unique activity of this cytokine to acutely block the expression of an inflammatory cytokine in human T cells.
The results show that STAT4 plays a critical role in mediating both Th1 (zeige HAND1 Proteine) and Th2 responses upon immunization with monophosphoryl lipid A.
this study shows that STAT4 regulates the CD8 (zeige CD8A Proteine)(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin (zeige INS Proteine)-resistant Ldlr (zeige LDLR Proteine)(-/-) mice
virus-specific effector and memory CD4 (zeige CD4 Proteine) T cells formed independently of Tbet and STAT4, although a slight reduction in the number of antigen-specific CD4 (zeige CD4 Proteine) T cells was apparent in mice lacking both transcription factors.
STAT4 has a pro-atherogenic role that is at least partially independent of Th1 (zeige HAND1 Proteine) cell-derived interferon-gamma (zeige IFNG Proteine)
Modulation of IL-12 (zeige IL12A Proteine)/STAT4 signaling may be a valuable therapeutic strategy to preserve islet/beta-cell viability in established diabetes
This study found that stathmin (zeige STMN1 Proteine) plays an important role in adult hippocampal neurogenesis and spinogenesis. In addition, stathmin (zeige STMN1 Proteine) mutation led to impaired NMDA receptor-dependent and neurogenesis-associated memory
STAT4 controls GM-CSF (zeige CSF2 Proteine) production by both Th1 (zeige HAND1 Proteine) and Th17 cells during experimental autoimmune encephalomyelitis.
Data (including data from studies in knockout mice) suggest Stat4 deletion reduces inflammation in peri (zeige POSTN Proteine)-vascular and visceral adipose tissue and this appears to contribute via direct or indirect effects to reduced atheroma formation.
T-bet- and STAT4-dependent IL-33 (zeige IL33 Proteine) receptor expression have roles in directly promoting antiviral Th1 (zeige HAND1 Proteine) cell responses
Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrated that T cell receptor stimulation induced responsiveness for IFN-gamma (zeige IFNG Proteine) and CD25 (zeige IL2RA Proteine) induction through STAT4-independent pathways.
These results suggest that the 2 single nucleotide polymorphisms of STAT4 could be used as genetic markers for milk performance traits in Chinese Holstein cows.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
signal transducer and activator of transcription 4