anti-JAK1 (JAK1) Antikörper

Bezeichnung:
anti-Janus Kinase 1 Antikörper (JAK1)
Auf www.antikoerper-online.de finden Sie aktuell 139 Janus Kinase 1 (JAK1) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen JAK1 Kits (23) und JAK1 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 184 JAK1 Produkte verfügbar.
Synonyme:
AA960307, C130039L05Rik, jak1, JAK1A, JAK1B, JNK, JNK1, JTK3, wu:fb93e10
Alle Antikörper anzeigen Gen GeneID UniProt
JAK1 3716 P23458
JAK1 16451  
JAK1 84598  

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Meistgesuchte Reaktivitäten zu anti-JAK1 (JAK1) Antikörper

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anti-Human JAK1 Antikörper:

anti-Mouse (Murine) JAK1 Antikörper:

anti-Rat (Rattus) JAK1 Antikörper:

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Am meisten referenzierte anti-JAK1 Antikörper

  1. Chicken Monoclonal JAK1 Primary Antibody für IF, IP - ABIN967842 : Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. in Oncogene 2001 (PubMed)
    Zeige alle 5 Referenzen für 967842

  2. Human Polyclonal JAK1 Primary Antibody für IHC, WB - ABIN362146 : Zheng, Hu, Quinn, Wang: Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. in Molecular & cellular proteomics : MCP 2005 (PubMed)
    Zeige alle 4 Referenzen für 362146

  3. Human Polyclonal JAK1 Primary Antibody für IHC (p), WB - ABIN197300 : Wang, Griffin, Small, Thompson: Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide. in Archives of biochemistry and biophysics 2003 (PubMed)
    Zeige alle 2 Referenzen für 197300

  4. Human Polyclonal JAK1 Primary Antibody für IF, IHC - ABIN1533664 : Lee, Strunk, Spritz: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. in Oncogene 1993 (PubMed)

  5. Human Polyclonal JAK1 Primary Antibody für WB - ABIN265196 : Huang, Lin, Chen, Chang: Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells. in Journal of cellular biochemistry 2005 (PubMed)

Weitere Antikörper gegen JAK1 Interaktionspartner

Pig (Porcine) Janus Kinase 1 (JAK1) Interaktionspartner

  1. Porcine reproductive and respiratory syndrome virus -activated TAK-1 (zeige NR2C2 Antikörper) was essential for the activation of JNK (zeige MAPK8 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) pathways and IL-8 (zeige IL8 Antikörper) expression.

  2. Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (zeige JAK3 Antikörper)-STAT1 (zeige STAT1 Antikörper)) signaling pathway.

  3. Data show that proinflammatory cytokines induction was ERK1/2 (zeige MAPK1/3 Antikörper) and JNK1 (zeige MAPK8 Antikörper)/2 dependent.

  4. These data suggest that the p38 (zeige MAPK14 Antikörper) and JNK (zeige MAPK8 Antikörper) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.

  5. based on the data, we can conclude that JNK (zeige MAPK8 Antikörper) plays an active role in fragmentation of pig oocytes and that p38 MAPK (zeige MAPK14 Antikörper) is not involved in this process

  6. Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2 (zeige MAPK1/3 Antikörper), in the neuroretina and retinal arteries.

  7. PP2A (zeige PPP2R2B Antikörper) and AIP1 (zeige PDCD6IP Antikörper) cooperatively induce activation of ASK1 (zeige MAP3K5 Antikörper)-JNK (zeige MAPK8 Antikörper) signaling and vascular endothelial cell apoptosis.

  8. Phorbol 12-myristate 13-acetate activation of ERK (zeige MAPK1 Antikörper) and JNK (zeige MAPK8 Antikörper) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.

Rabbit Janus Kinase 1 (JAK1) Interaktionspartner

  1. This is the first report of the genetic polymorphisms of the JAK1 and STAT3 (zeige STAT3 Antikörper) genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Human Janus Kinase 1 (JAK1) Interaktionspartner

  1. Mechanistic investigations reveal that AJUBA (zeige AJUBA Antikörper) specifically binds the FERM domain of JAK1 to dissociate JAK1 from the IFNgamma recepter, resulting in an inhibition of STAT1 (zeige STAT1 Antikörper) phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA (zeige AJUBA Antikörper) in CRC (zeige CALR Antikörper) specimens is negatively correlated with the levels of IFIT2 (zeige IFIT2 Antikörper) and pSTAT1

  2. Multilevel genomic analyses of microsatellite instability+ colorectal cancer revealed molecular heterogeneity with clinical relevance, including tumor immunogenicity and a favorable patient outcome associated with JAK1 mutations and the transcriptomic subgroup CMS1

  3. a causal relationship between MLH1 (zeige MLH1 Antikörper)-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  4. Data show that moringin (GMG-ITC) had a limited inhibitory effect on IFNalpha-induced STAT1 (zeige STAT1 Antikörper) and STAT2 (zeige STAT2 Antikörper) activity, indicating differentially targeting JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signaling pathways.

  5. our studies highlight Jak1 as the first identified substrate for USP6 (zeige USP6 Antikörper), and they offer a mechanistic rationale for the clinical investigation of Jak (zeige JAK3 Antikörper) and STAT3 (zeige STAT3 Antikörper) inhibitors as therapeutics for the treatment of bone and soft tissue tumors along with other neoplasms driven by USP6 (zeige USP6 Antikörper) overexpression

  6. In this structure, the receptor peptide forms an 85-A-long extended chain, in which both the previously identified box1 and box2 regions bind simultaneously to the FERM and SH2-like domains of JAK1.

  7. Results reveal the structure of box1 from class II cytokine receptors IFNLR1 (zeige IL28RA Antikörper) and IL10RA (zeige IL10RA Antikörper) bound to the FERM-SH2 domain of human JAK1, identifying a consensus motif for JAK1 interaction.

  8. study demonstrated that miR (zeige MLXIP Antikörper)-9 could inhibit activation of the NLRP3 (zeige NLRP3 Antikörper) inflammasome and attenuate atherosclerosis-related inflammation, likely through the JAK1/STAT1 (zeige STAT1 Antikörper) signaling pathway. Therefore, miR (zeige MLXIP Antikörper)-9 may serve as a potential therapeutic target for atherosclerosis.

  9. miR (zeige MLXIP Antikörper)-340 suppressed HCC (zeige FAM126A Antikörper) cell proliferation and invasion by regulating the JAK1/STAT3 (zeige STAT3 Antikörper) pathway

  10. this study identifies a psoriasis-protective JAK1 haplotype in the Korean population

Mouse (Murine) Janus Kinase 1 (JAK1) Interaktionspartner

  1. JAK1-mediated signaling cascades in skin regulate the expression of proteases associated with the maintenance of skin barrier function and demonstrate that perturbation of these pathways can lead to the development of spontaneous pruritic dermatitis.

  2. Small-scale in vivo screening identified several genes, including Cd109 (zeige CD109 Antikörper), that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (zeige STAT3 Antikörper) as a critical, pharmacologically targetable effector of CD109 (zeige CD109 Antikörper)-driven lung cancer metastasis

  3. a causal relationship between MLH1 (zeige MLH1 Antikörper)-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  4. High JAK1 expression is associated with Hepatic Fibrosis.

  5. findings demonstrate that clinically relevant doses of the JAK1/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.

  6. Data show that CUZD1 (zeige CUZD1 Antikörper) interacts with a complex containing JAK1/JAK2 (zeige JAK2 Antikörper) and STAT5 (zeige STAT5A Antikörper), downstream transducers of prolactin (zeige PRL Antikörper) signaling in the mammary gland.

  7. JAK1 conditional knockout mice will be an invaluable tool to study cytokine signaling during normal development and disease progression in adult animals.

  8. JAK1, JAK2 (zeige JAK2 Antikörper), and JAK3 (zeige JAK3 Antikörper) are involved in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor.

  9. JAK (zeige JAK3 Antikörper) mediated signaling is involved in the differentiation and proliferation of mesenchymal progenitor cells.

  10. Data indicate thar Janus kinase 1 (Jak1) degradation is dependent on Nedd4 family interacting proteins Ndfip1 (zeige NDFIP1 Antikörper)/Ndfip2 (zeige NDFIP2 Antikörper).

Zebrafish Janus Kinase 1 (JAK1) Interaktionspartner

  1. JAK1 activating mutants are insufficient to drive hepatocellular carcinoma development in vivo.

JAK1 Antigen-Profil

Beschreibung des Gens

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Alternative names and synonyms associated with JAK1

  • Janus kinase 1 (JAK1) Antikörper
  • mitogen-activated protein kinase 8 (MAPK8) Antikörper
  • Tyrosine-protein kinase Jak1 (jak1) Antikörper
  • Janus kinase 1 (jak1) Antikörper
  • Janus kinase 1 (Jak1) Antikörper
  • AA960307 Antikörper
  • C130039L05Rik Antikörper
  • jak1 Antikörper
  • JAK1A Antikörper
  • JAK1B Antikörper
  • JNK Antikörper
  • JNK1 Antikörper
  • JTK3 Antikörper
  • wu:fb93e10 Antikörper

Bezeichner auf Proteinebene für anti-Janus Kinase 1 (JAK1) Antikörper

Janus kinase 1 (a protein tyrosine kinase) , protein tyrosine kinase , tyrosine kinase JAK1 , tyrosine-protein kinase JAK1 , janus kinase 1 , Janus kinase 1 , Tyrosine-protein kinase Jak1 , tyrosine-protein kinase JAK1-like , JAK-1 , Janus protein tyrosine kinase 1 , etID309794.6 , fb93e10 , jak-1 , jak1 kinase

GENE ID SPEZIES
442952 Canis lupus familiaris
395681 Gallus gallus
396610 Sus scrofa
677689 Macaca mulatta
697808 Macaca mulatta
743373 Pan troglodytes
100031307 Monodelphis domestica
100286690 Salmo salar
100352594 Oryctolagus cuniculus
100385835 Callithrix jacchus
100433477 Pongo abelii
100473460 Ailuropoda melanoleuca
100559328 Anolis carolinensis
3716 Homo sapiens
16451 Mus musculus
84598 Rattus norvegicus
397202 Sus scrofa
537201 Bos taurus
30280 Danio rerio
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