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Chimeric fusion protein of interleukin 2 (IL2 (zeige IL2 ELISA Kits)) and its receptor interleukin 2 (zeige IL2 ELISA Kits) receptor, beta protein (IL2Rbeta) enhances antitumor activity of natural killer NK92 cells.
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2 (zeige IL2 ELISA Kits)- and IL-15 (zeige IL15 ELISA Kits)-activated T-cells has been reported.
Among patients with a low pretreatment sIL (zeige PMEL ELISA Kits)-2R level who exhibited a positive response to R-CHOP (zeige DDIT3 ELISA Kits), the posttreatment sIL (zeige PMEL ELISA Kits)-2R level may help to identify those with a poor prognosis.
Studies indicate many potential uses of soluble interleukin-2 (zeige IL2 ELISA Kits) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
IL2RB thr (zeige TRH ELISA Kits)-450 phosphorylation is a positive regulator for receptor-IL-2 (zeige IL2 ELISA Kits) complex stability and activation of signaling molecules.
An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA (zeige PRTN3 ELISA Kits) positive Rheumatoid arthritis patients.
CD112 (zeige PVRL2 ELISA Kits) downregulation resulted in a reduced ability of DNAM-1 (zeige CD226 ELISA Kits) to bind to the surface of both virus-infected and gD-transfected cells.
IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis.
in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes.
IL2RA (zeige IL2RA ELISA Kits) and IL2RB as promising candidate genes for inflammatory bowel diseases(IBD) and suggesting a potential role of IL2R (zeige IL2RA ELISA Kits) in the pathogenesis of IBD, likely involves regulatory T cells.
c-REL (zeige NFkBP65 ELISA Kits), but not IkappaBNS, controlled the generation of classical CD25 (zeige IL2RA ELISA Kits)(+)Foxp3 (zeige FOXP3 ELISA Kits)(-) precursors via direct binding to the Cd25 (zeige IL2RA ELISA Kits) locus; propose that CD4 (zeige CD4 ELISA Kits)(+)GITR (zeige TNFRSF18 ELISA Kits)(+)CD122(+)CD25 (zeige IL2RA ELISA Kits)(-)Foxp3 (zeige FOXP3 ELISA Kits)(-) cells represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via c-REL (zeige NFkBP65 ELISA Kits)
Results indicate that conjugated-interleukin-2 (IL2 (zeige IL2 ELISA Kits)) protein derived from NKTR (zeige NKTR ELISA Kits)-214 occupy interleukin-2 (IL2 (zeige IL2 ELISA Kits)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (zeige IL2 ELISA Kits) protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2 (zeige IL2 ELISA Kits)-beta receptor response, to date classically described only in immune cells.
CBP (zeige CREBBP ELISA Kits) physically associates with the IL-2 receptor beta-chain. CBP (zeige CREBBP ELISA Kits), found in the nucleus in resting CTLL-2 cells, relocates to the cytoplasm after IL-2 (zeige IL2 ELISA Kits) stimulation in an MEK (zeige MDK ELISA Kits)/ERK (zeige EPHB2 ELISA Kits) pathway-dependent manner. Thus, IL-2 (zeige IL2 ELISA Kits)-mediated acetylation plays an important role in the modulation of cytokine signaling and T cell fate.
Intratesticular inoculation with donor antigens promotes long-term skin allograft survival induced by conventional costimulatory blockade via the induction of both CD8 (zeige CD8A ELISA Kits) + CD122+ and CD4 (zeige CD4 ELISA Kits) + CD25 (zeige IL2RA ELISA Kits)+ Treg cells.
IL-2Rbeta-dependent signaling and CD103 (zeige ITGAE ELISA Kits) functionally cooperate to maintain tolerance in the gut (zeige GUSB ELISA Kits) mucosa.
Thymic development of CD4 (zeige CD4 ELISA Kits)+Foxp3 (zeige FOXP3 ELISA Kits)+ regulatory T cells (Tregs) is highly dysregulated in IL-2 (zeige IL2 ELISA Kits) receptor (2Rbeta)-deficient mice.
CDCD11c+B220 (zeige PTPRC ELISA Kits)+CD122+ cells play an important role in xenograft rejection. Their absence in NOG (zeige NOG ELISA Kits) mice may be critical in supporting the successful engraftment of xenotransplants.
This study demonstrated that IL-12 (zeige IL12A ELISA Kits) signaling plays a complex role during the induction of tolerance as the presence of exogenous IL-12 (zeige IL12A ELISA Kits) and the lack of IL-12 (zeige IL12A ELISA Kits) signaling both prevent complete induction of tolerance.
Continuous activation of the CD122/STAT-5 (zeige STAT5A ELISA Kits) signaling pathway characterize regulatory lineage differentiation in the murine thymus.
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
IL 2/15 receptor beta chain
, interleukin 2 receptor, beta
, interleukin-2 receptor subunit beta
, CD122 antigen
, IL-2 receptor subunit beta
, IL-2R subunit beta
, high affinity IL-2 receptor beta subunit
, high affinity IL-2 receptor subunit beta
, interleukin 15 receptor, beta
, interleukin 2 receptor, beta chain
, IL-15 receptor beta chain
, IL-2 receptor beta chain
, IL-2/15 receptor-beta