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transfusion-induced differentiation of IFNAR1(-/-) B cells into germinal center B cells and plasma cells was significantly reduced, compared to WT B cells. This study demonstrates that B cells require signaling from IFN-alpha (zeige IFNA ELISA Kits)/beta to produce alloantibodies to the human KEL glycoprotein in mice.
These data suggest that plasmacytoid dendritic cells producing IFN-alpha (zeige IFNA ELISA Kits) and IL-33 (zeige IL33 ELISA Kits) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (zeige CCL1 ELISA Kits) expression including CCL2 (zeige CCL2 ELISA Kits).
this study shows that the presence of IFN-alpha (zeige IFNA ELISA Kits) at antigen sensitization activates an IDO1 (zeige IDO1 ELISA Kits)/TGF-beta (zeige TGFB1 ELISA Kits)-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells
these studies demonstrate an important role for type I IFN in skin fibrosis, and they provide a rationale for IFNAR1 inhibition in scleroderma
These results identify a key interface created by IFNAR1 residues Tyr (zeige TYR ELISA Kits)(240) and Tyr (zeige TYR ELISA Kits)(274) interacting with IFN-beta (zeige IFNB1 ELISA Kits) residues Phe(63), Leu(64), Glu (zeige GCG ELISA Kits)(77), Thr (zeige TRH ELISA Kits)(78), Val(81), and Arg(82) that underlie IFN-beta (zeige IFNB1 ELISA Kits)-IFNAR1-mediated signaling and biological processes.
IFNAR1-deficiency accelerated humoral immune responses and parasite control by boosting ICOS (zeige ICOS ELISA Kits)-signalling in two non-lethal murine models of malaria
reduced type I interferon (zeige IFNA ELISA Kits) production in obesity is caused by SOCS3 (zeige SOCS3 ELISA Kits) overexpression as well as tolerance induced by leptin (zeige LEP ELISA Kits)
Downregulation of IFNAR1 promotes melanoma development and progression. IFNAR1 mutation, which is partially resistant to downregulation, delays melanoma development.
The study provides evidence for the importance of brain endothelial and epithelial cells in the communication between the Central Nervous System and the immune system, and demonstrates tissue specific IFNAR1 engagement during sickness behavior.
Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer.
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche.
These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication.
On one hand, hepatitis B virus activates MMP-9 (zeige MMP9 ELISA Kits) in infected patients and leukocytes. On the other hand, MMP-9 (zeige MMP9 ELISA Kits) facilitates hepatitis B virus replication through repressing IFN/JAK (zeige JAK3 ELISA Kits)/STAT (zeige STAT1 ELISA Kits) signaling, IFNAR1 function, and IFN-alpha (zeige IFNA ELISA Kits) action.
this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo (zeige MITF ELISA Kits) in Estonian patients
A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1.
rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations.
Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection.
data illustrate a lipid G-protein coupled receptor (GPCR (zeige TAS1R3 ELISA Kits))-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 (zeige S1PR1 ELISA Kits) signaling
Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 (zeige IFNA2 ELISA Kits) generates type I IFN competitive antagonists.
The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNAR1 gene was determined.
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
interferon alpha/beta receptor 1
, interferon receptor
, soluble receptor
, interferon-alpha receptor 1
, putative interferon-alpha/beta receptor alpha chain
, interferon receptor 1
, interferon (alpha, beta and omega) receptor 1
, interferon alpha/beta receptor 1-like
, IFN-alpha/beta receptor 1
, INF-a receptor
, interferon-alpha/beta receptor 1
, type I interferon receptor 1
, alpha-type antiviral protein
, beta-type antiviral protein
, cytokine receptor class-II member 1
, cytokine receptor family 2 member 1
, interferon-alpha/beta receptor alpha chain
, interferon-beta receptor 1
, interferon (alpha and beta) receptor 1
, interferon, alpha; receptor
, Interferon-alpha/beta receptor alpha chain