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We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively.
Yes kinase plays an important role in epiboly and indicate that Yes kinase participates in signaling by focal adhesion kinase during early development.
Fyn kinase plays an important role in epiboly during zebrafish development, possibly through its effects in calcium signaling.
Fyn, and possibly other Src (zeige SRC Proteine) family members are activated by dephosphorylation of the C-terminal tyrosine at fertilization
investigated signaling pathways in early development by comparison of the phosphoproteome of wild type embryos with Fyn/Yes knockdown embryos that display specific convergence and extension cell movement defects
upregulated in fibrotic kidneys
Study identified the binding site between tau and fyn-SH3 may facilitate the development of compounds that can inhibit tau-fyn interactions, which presents an alternative therapeutic strategy for Alzheimer's disease; and provide evidence that a physiological correlation between phosphorylated tau at S202, S262, and S396/404 and fyn is not present in Alzheimer's disease brain.
FYN expression is regulated according to AD status and regulatory region haplotype, and genetic variants may be instrumental in the development of neurofibrillary tangles in AD and other tauopathies.
a substantial fraction of unligated CD36 (zeige CD36 Proteine) exists in nanoclusters, which not only promote TSP-1 (zeige THBS1 Proteine) binding but are also enriched with the downstream effector Fyn.
Upon SMAD4 (zeige SMAD4 Proteine) deletion, we detected high expression levels of FYN in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype
Study reveal that binding the phosphorylated tail of Fyn perturbs a residue cluster near the linker connecting the SH2 and SH3 domains of Fyn, which is known to be relevant in the regulation of the activity of Fyn.
The data suggest that miR (zeige MLXIP Proteine)-106b inhibits Amyloid-beta (1-42)-induced tau phosphorylation at Tyrosine 18 by targeting Fyn.
FYN was transcriptionally regulated by FOXO1 (zeige FOXO1 Proteine).
Results found that GluN2B (zeige GRIN2B Proteine) subunit-containing NMDARs were dominant in induced pluripotent stem cell-derived neurons and that tyrosine-protein kinase Fyn potentiated the function of GluN2B (zeige GRIN2B Proteine) subunit-containing NMDARs.
Data show that fyn proto-oncogene protein (FYN) expression is deregulated in acute myeloid leukemia (zeige BCL11A Proteine) and that higher expression of FYN, in combination with FLT3 (zeige FLT3 Proteine) protein-ITD mutation, resulted in enrichment of the STAT5 (zeige STAT5A Proteine) transcription factor signaling.
We conclude that the hypoxia-induced activation of caspase-9 (zeige CASP9 Proteine) is mediated by Src kinase (zeige CSK Proteine).
Fyn oncogene (zeige RAB1A Proteine) alternative spliced forms have been isolated from brain and spleen.
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.
PECAM-1 (zeige PECAM1 Proteine) and Fyn are essential components of a PECAM-1 (zeige PECAM1 Proteine)-based mechanosensory complex in endothelial cells.
Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation.
loss of Fyn in the kidney prevents unilateral ureteral obstruction-induced tubulointerstitial fibrosis, mediated by a reduction in STAT3 (zeige STAT3 Proteine) phosphorylation
results show that Fyn kinase is an important positive effector of TGF-beta (zeige TGFB1 Proteine)-induced chemotaxis through the control of phosphatase PP2A (zeige PPP2R2B Proteine) activity and this is relevant to pathological processes that are related to TGF-beta (zeige TGFB1 Proteine)-dependent mast cell migration
In summary,MAGI-2 (zeige MAGI2 Proteine) and Fyn protect dendrin from Nedd4-2 (zeige NEDD4L Proteine)-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes.
FYN is activated by oxidative stress and serves as a negative feedback regulator of NOX4 (zeige NOX4 Proteine) in cardiomyocytes during cardiac remodeling
The results of this study suggested that Fyn-mediated NR2B (zeige GRIN2B Proteine) signaling plays a critical role in regulation of prediabetic neuropathy and that the increased expression/function of NR2B (zeige GRIN2B Proteine) subunit-containing NMDARs may contribute to the progression of neuropathy in type 2 diabetes
Fyn acts as a regulatory nexus between solar UV, ROS (zeige ROS1 Proteine) and signal transduction during skin carcinogenesis.
We show that PTP-3, a LAR (zeige PTPRF Proteine) homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR (zeige PTPRF Proteine) class PTPs (zeige PTS Proteine), is involved in Sema3A (zeige SEMA3A Proteine)-regulated cortical dendritic growth. In Sema3A (zeige SEMA3A Proteine) signaling, PTPdelta activates Fyn and Src (zeige SRC Proteine) kinases by dephosphorylating their C-terminal Tyr (zeige TYR Proteine) residues.
data show that Fyn kinase is activated after TLR4 (zeige TLR4 Proteine) triggering and exerts an important negative control on LPS (zeige TLR4 Proteine)-dependent TNF (zeige TNF Proteine) production in mast cells controlling the inactivation of PP2Ac (zeige PPP2CA Proteine) and activation of PKCalpha (zeige PKCa Proteine)/beta necessary for the secretion of TNF (zeige TNF Proteine) by VAMP3 (zeige VAMP3 Proteine)(+) carriers
Fyn deficiency alters retinal morphology and adhesion properties of Muller cells. Fyn deficiency parallels a decreased optokinetic response to visual stimuli in vivo.
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
protein-tyrosine kinase fyn
, proto-oncogene tyrosine-protein kinase fyn
, Fyn non-receptor tyrosine kinase
, proto-oncogene c-Fynb
, tyrosine-protein kinase fynb
, FYN oncogene related to SRC, FGR, YES
, proto-oncogene tyrosine-protein kinase fyn-like
, tyrosine-protein kinase Fyn-like
, proto-oncogene c-Fyn
, proto-oncogene tyrosine-protein kinase Fyn
, tyrosine-protein kinase Fyn
, OKT3-induced calcium influx regulator
, c-syn protooncogene
, proto-oncogene Syn
, src-like kinase
, src/yes-related novel
, tyrosine kinase p59fyn(T)
, fyn proto-oncogene
, c-fyn, fyn proto-oncogene
, protein-tyrosine kinase
, proto-oncogene c-Fyna
, tyrosine-protein kinase fyna
, Src Kinase p59