FYN Proteine (FYN)

Bezeichnung:
FYN Oncogene Related To SRC, FGR, YES Proteine (FYN)
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Synonyme:
AI448320, AW552119, c-fyn, cfyn-a, fyn, im:6908851, p59-FYN, PKC, si:dkey-119m7.5, SLK, SYN, zgc:86720, zgc:109996
alle Proteine anzeigen Gen GeneID UniProt
FYN 2534 P06241
FYN 25150 Q62844
FYN 14360 P39688

Weitere Synonyme anzeigen

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Weitere Proteine zu FYN Interaktionspartnern

Zebrafish FYN Oncogene Related To SRC, FGR, YES (FYN) Interaktionspartner

  1. We also show that activation and reduction of Fyn kinase in oligodendrocytes increases and decreases sheath number per cell, respectively.

  2. Yes kinase plays an important role in epiboly and indicate that Yes kinase participates in signaling by focal adhesion kinase during early development.

  3. Fyn kinase plays an important role in epiboly during zebrafish development, possibly through its effects in calcium signaling.

  4. Fyn, and possibly other Src (zeige SRC Proteine) family members are activated by dephosphorylation of the C-terminal tyrosine at fertilization

  5. investigated signaling pathways in early development by comparison of the phosphoproteome of wild type embryos with Fyn/Yes knockdown embryos that display specific convergence and extension cell movement defects

Human FYN Oncogene Related To SRC, FGR, YES (FYN) Interaktionspartner

  1. a substantial fraction of unligated CD36 (zeige CD36 Proteine) exists in nanoclusters, which not only promote TSP-1 (zeige THBS1 Proteine) binding but are also enriched with the downstream effector Fyn.

  2. Upon SMAD4 (zeige SMAD4 Proteine) deletion, we detected high expression levels of FYN in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype

  3. Study reveal that binding the phosphorylated tail of Fyn perturbs a residue cluster near the linker connecting the SH2 and SH3 domains of Fyn, which is known to be relevant in the regulation of the activity of Fyn.

  4. The data suggest that miR (zeige MLXIP Proteine)-106b inhibits Amyloid-beta (1-42)-induced tau phosphorylation at Tyrosine 18 by targeting Fyn.

  5. FYN was transcriptionally regulated by FOXO1 (zeige FOXO1 Proteine).

  6. Results found that GluN2B (zeige GRIN2B Proteine) subunit-containing NMDARs were dominant in induced pluripotent stem cell-derived neurons and that tyrosine-protein kinase Fyn potentiated the function of GluN2B (zeige GRIN2B Proteine) subunit-containing NMDARs.

  7. Data show that fyn proto-oncogene protein (FYN) expression is deregulated in acute myeloid leukemia (zeige BCL11A Proteine) and that higher expression of FYN, in combination with FLT3 (zeige FLT3 Proteine) protein-ITD mutation, resulted in enrichment of the STAT5 (zeige STAT5A Proteine) transcription factor signaling.

  8. These results indicate that the microenvironment and growth patterns in an multicellular spheroid are complex and require MAPK (zeige MAPK1 Proteine) and FYN kinase

  9. this study shows that p59(fyn), which is essential for activation of T cells through the T-cell receptor, is also critical for signal transduction through Toll (zeige TLR4 Proteine)-like receptors in T cells

  10. Fyn expression fluctuated with the progress of normal pregnancy and was elevated in patients with recurrent spontaneous abortion

Pig (Porcine) FYN Oncogene Related To SRC, FGR, YES (FYN) Interaktionspartner

  1. We conclude that the hypoxia-induced activation of caspase-9 (zeige CASP9 Proteine) is mediated by Src kinase (zeige CSK Proteine).

  2. Fyn oncogene (zeige RAB1A Proteine) alternative spliced forms have been isolated from brain and spleen.

Cow (Bovine) FYN Oncogene Related To SRC, FGR, YES (FYN) Interaktionspartner

  1. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn.

  2. PECAM-1 (zeige PECAM1 Proteine) and Fyn are essential components of a PECAM-1 (zeige PECAM1 Proteine)-based mechanosensory complex in endothelial cells.

Mouse (Murine) FYN Oncogene Related To SRC, FGR, YES (FYN) Interaktionspartner

  1. The results of this study suggested that Fyn-mediated NR2B (zeige GRIN2B Proteine) signaling plays a critical role in regulation of prediabetic neuropathy and that the increased expression/function of NR2B (zeige GRIN2B Proteine) subunit-containing NMDARs may contribute to the progression of neuropathy in type 2 diabetes

  2. Fyn acts as a regulatory nexus between solar UV, ROS (zeige ROS1 Proteine) and signal transduction during skin carcinogenesis.

  3. We show that PTP-3, a LAR (zeige PTPRF Proteine) homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR (zeige PTPRF Proteine) class PTPs (zeige PTS Proteine), is involved in Sema3A (zeige SEMA3A Proteine)-regulated cortical dendritic growth. In Sema3A (zeige SEMA3A Proteine) signaling, PTPdelta activates Fyn and Src (zeige SRC Proteine) kinases by dephosphorylating their C-terminal Tyr (zeige TYR Proteine) residues.

  4. data show that Fyn kinase is activated after TLR4 (zeige TLR4 Proteine) triggering and exerts an important negative control on LPS (zeige TLR4 Proteine)-dependent TNF (zeige TNF Proteine) production in mast cells controlling the inactivation of PP2Ac (zeige PPP2CA Proteine) and activation of PKCalpha (zeige PKCa Proteine)/beta necessary for the secretion of TNF (zeige TNF Proteine) by VAMP3 (zeige VAMP3 Proteine)(+) carriers

  5. Fyn deficiency alters retinal morphology and adhesion properties of Muller cells. Fyn deficiency parallels a decreased optokinetic response to visual stimuli in vivo.

  6. Fyn mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (zeige PXN Proteine) phosphorylation

  7. MOBP (zeige MOBP Proteine) synthesis is stimulated by Fyn activity.

  8. Fyn expression was elevated in abortion-prone mice

  9. Fyn facilitates mitotic spindle formation through the increase in microtubule polymerization, resulting in the acceleration of M-phase progression.

  10. Results identified Fyn kinase as a molecular mediator of BDNF signaling that activates Erk1/2 and promotes oligodendrocyte myelination

FYN Protein Überblick

Protein Überblick

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

Alternative names and synonyms associated with FYN

  • FYN oncogene related to SRC, FGR, YES (FYN)
  • FYN oncogene related to SRC, FGR, YES (fyn)
  • FYN oncogene related to SRC, FGR, YES b (fynb)
  • c-fyn protein (fyn)
  • FYN oncogene related to SRC, FGR, YES (Fyn)
  • FYN oncogene related to SRC, FGR, YES a (fyna)
  • Fyn proto-oncogene (Fyn)
  • AI448320 Protein
  • AW552119 Protein
  • c-fyn Protein
  • cfyn-a Protein
  • fyn Protein
  • im:6908851 Protein
  • p59-FYN Protein
  • PKC Protein
  • si:dkey-119m7.5 Protein
  • SLK Protein
  • SYN Protein
  • zgc:86720 Protein
  • zgc:109996 Protein

Bezeichner auf Proteinebene für FYN

protein-tyrosine kinase fyn , proto-oncogene tyrosine-protein kinase fyn , Fyn non-receptor tyrosine kinase , proto-oncogene c-Fynb , tyrosine-protein kinase fynb , FYN oncogene related to SRC, FGR, YES , proto-oncogene tyrosine-protein kinase fyn-like , tyrosine-protein kinase Fyn-like , p59-Fyn , proto-oncogene c-Fyn , proto-oncogene tyrosine-protein kinase Fyn , tyrosine-protein kinase Fyn , OKT3-induced calcium influx regulator , c-syn protooncogene , proto-oncogene Syn , src-like kinase , src/yes-related novel , tyrosine kinase p59fyn(T) , fyn proto-oncogene , c-fyn, fyn proto-oncogene , protein-tyrosine kinase , proto-oncogene c-Fyna , tyrosine-protein kinase fyna , Src Kinase p59

GENE ID SPEZIES
462944 Pan troglodytes
379812 Xenopus laevis
574214 Macaca mulatta
574422 Danio rerio
100339741 Oryctolagus cuniculus
100439712 Pongo abelii
100585303 Nomascus leucogenys
373609 Xenopus laevis
2534 Homo sapiens
25150 Rattus norvegicus
475032 Canis lupus familiaris
791125 Sus scrofa
527263 Bos taurus
396294 Gallus gallus
373872 Danio rerio
14360 Mus musculus
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