CISH Proteine (CISH)

Cytokine Inducible SH2-Containing Protein Proteine (CISH)
Auf finden Sie aktuell 10 Cytokine Inducible SH2-Containing Protein (CISH) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CISH Antikörper (31) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 45 CISH Produkte verfügbar.
AI385595, BACTS2, Cis, CIS-1, CIS1, cish, cish.a, F17, F23, G18, ptk9l, SOCS, twf1l, wu:fk57g04, zgc:91817, zgc:154062
alle Proteine anzeigen Gen GeneID UniProt
CISH 1154 Q9NSE2
CISH 12700 Q62225
CISH 83681  

Weitere Synonyme anzeigen

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Weitere Proteine zu CISH Interaktionspartnern

Zebrafish Cytokine Inducible SH2-Containing Protein (CISH) Interaktionspartner

  1. This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 (zeige STAT5B Proteine) in the control of embryonic hematopoiesis.

Rainbow Trout (Oncorhynchus mykiss) Cytokine Inducible SH2-Containing Protein (CISH) Interaktionspartner

  1. the type II SOCS genes (CISH, SOCS1 (zeige SOCS1 Proteine)-3) are particularly relevant to immune regulation in fish

Human Cytokine Inducible SH2-Containing Protein (CISH) Interaktionspartner

  1. CISH rs414171 and rs6768300 variants might be associated with protection from pulmonary tuberculosis in Zahedan, Southeast Iran.

  2. This study showed that there was significantly increased levels of CIS mRNA in elderly and Alzheimer's disease brains.

  3. Data indicate that CIS protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with Elongin B (zeige TCEB2 Proteine)/C proteins, whereas CIS functional inhibition of PRLR (zeige PRLR Proteine) signaling is dependent on the Elongin B (zeige TCEB2 Proteine)/C interaction.

  4. SOCS single nucleotide polymorphism is associated with breast cancer.

  5. Study in Chinese Han population confirms that previously identified variants of CISH are associated with susceptibility to pulmonary tuberculosis.

  6. CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.

  7. Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population

  8. two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population

  9. CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis

  10. methylation of SOCS1 (zeige SOCS1 Proteine), SOCS2 (zeige SOCS2 Proteine), SOCS3 (zeige SOCS3 Proteine) and CISH is infrequent in Ph-ve MPN (zeige PRSS27 Proteine).

Mouse (Murine) Cytokine Inducible SH2-Containing Protein (CISH) Interaktionspartner

  1. this study identifies CIS as a critical negative regulator of IL-15 (zeige IL15 Proteine) signaling in NK cells

  2. Data show that cytokine inducible SH2-containing protein Cish is induced upon T cell receptor stimulation and in the tumor microenvironment.

  3. Results show that CISH has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 (zeige SOCS2 Proteine) might compensate for the loss of Cish during pregnancy.

  4. CIS has a critical role in controlling the proallergic generation of helper T cells.

  5. CISH expression at the later stage of dendritic cell development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs.

  6. CIS and SOCS3 (zeige SOCS3 Proteine) play a role as negative feedback inhibitors of PRL (zeige PRL Proteine) action; Inhibition of CIS and SOCS3 (zeige SOCS3 Proteine) expression by glucocorticoids contributes to the positive effect of glucocorticoids on PRL (zeige PRL Proteine)-induced STAT5 (zeige STAT5A Proteine) activation.

  7. Induction of CIS in response to EPO (zeige EPO Proteine) stimulation depends on Stat5 (zeige STAT5A Proteine) but not MAP kinase (zeige MAPK1 Proteine) or PI 3 (zeige PI3 Proteine)-kinase. Overexpression negatively regulates EPO (zeige EPO Proteine)-mediated cell proliferation, Stat5 (zeige STAT5A Proteine) phosphorylation, & activation of a Stat (zeige STAT1 Proteine)-dependent luciferase reporter.

  8. CIS negatively regulates signaling at two levels, apoptosis and proliferation, and thereby sets a threshold for signal transduction

  9. IL-6 (zeige IL6 Proteine) inhibits hepatic GH signaling by upregulating Cis and Socs-3 (zeige SOCS3 Proteine), which may involve activation of STAT3 (zeige STAT3 Proteine).

  10. histone acetylation and chromatin remodeling events occurring during transcriptional activation of the endogenous murine Cis gene, a STAT5 (zeige STAT5A Proteine) target gene

CISH Protein Überblick

Protein Überblick

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CISH

  • cytokine inducible SH2-containing protein (CISH)
  • cytokine inducible SH2-containing protein (cish)
  • cytokine-inducible SH2-containing protein (cish)
  • Cytokine-inducible SH2-containing protein (cish)
  • cytokine inducible SH2-containing protein (Cish)
  • AI385595 Protein
  • BACTS2 Protein
  • Cis Protein
  • CIS-1 Protein
  • CIS1 Protein
  • cish Protein
  • cish.a Protein
  • F17 Protein
  • F23 Protein
  • G18 Protein
  • ptk9l Protein
  • SOCS Protein
  • twf1l Protein
  • wu:fk57g04 Protein
  • zgc:91817 Protein
  • zgc:154062 Protein

Bezeichner auf Proteinebene für CISH

cytokine inducible SH2-containing protein , cytokine-inducible SH2-containing protein , cytokine inducible SH2 containing protein , cytokine inducible SH2-containing protein A , twinfilin, actin-binding protein, homolog 1, like , Cytokine-inducible SH2-containing protein , cytokine-inducible inhibitor of signaling type 1B , suppressor of cytokine signaling , CIS-1 , SOCS , cytokine-inducible SH2 protein , cytokine inducible SH2-containing protein 1 , CIS

470819 Pan troglodytes
484757 Canis lupus familiaris
701456 Macaca mulatta
767678 Danio rerio
100135018 Xenopus (Silurana) tropicalis
100144307 Takifugu rubripes
100144373 Oryzias latipes
100190868 Gasterosteus aculeatus
100196184 Salmo salar
100329195 Oncorhynchus mykiss
1154 Homo sapiens
12700 Mus musculus
83681 Rattus norvegicus
616753 Bos taurus
395335 Gallus gallus
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