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RNF4 Proteine (RNF4)

Bezeichnung:
Ring Finger Protein 4 Proteine (RNF4)
Auf www.antikoerper-online.de finden Sie aktuell 8 Ring Finger Protein 4 (RNF4) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RNF4 Kits (19) und RNF4 Antikörper (17) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 46 RNF4 Produkte verfügbar.
Synonyme:
AU018689, Gtrgeo8, SLX5, SNURF
alle Proteine anzeigen Gen GeneID UniProt
RNF4 6047 P78317
RNF4 19822 Q9QZS2
RNF4 29274 O88846

Weitere Synonyme anzeigen

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Am meisten referenzierte RNF4 Proteine

  1. Human RNF4 Protein expressed in Escherichia coli (E. coli) - ABIN1098423 : Guo, Sharrocks et al.: Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional ... in Molecular and cellular biology 2009 (PubMed)
    Zeige alle 2 Referenzen für ABIN1098423

Weitere Proteine zu RNF4 Interaktionspartnern

Human Ring Finger Protein 4 (RNF4) Interaktionspartner

  1. These results point to an important role of the affinity between RNF4 and its cognate RAD6B (zeige UBE2B Proteine) or UBCH5B (zeige UBE2D2 Proteine) in governing the multiplicity of substrate ubiquitination.

  2. the opposing activities of RNF4 and ataxin-3 consolidate robust MDC1-dependent signaling and repair ofDNA double-strand break.

  3. Combined effect of dynamic recruitment of RNF4 to KAP1 regulates the relative occupancy of 53BP1 and BRCA1 at double-strand break sites to direct DNA repair in a cell cycle-dependent manner.

  4. c-Myc (zeige MYC Proteine) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1 (zeige PIAS1 Proteine), SENP7 (zeige SENP7 Proteine) and RNF4

  5. Data show that RNF4 is a SUMO-targeted ubiquitin ligase that targets TRF2 (zeige TERF2 Proteine) for ubiquitination.

  6. novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR (zeige DDR1 Proteine).

  7. RNF4 negatively regulates NF-kappaB (zeige NFKB1 Proteine) signaling by down-regulating TAB2 (zeige TAB2 Proteine)

  8. RNF4 enhances Ube2E1 (zeige UBE2E1 Proteine) self-ubiquitination.

  9. NMR spectroscopy and biochemical characterization reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer.

  10. RecQ-like helicase BLM subcellular localization is regulated by SUMO-targeted ubiquitin ligase RNF4 in response to DNA damage, presumably to prevent illegitimate recombination events.

Mouse (Murine) Ring Finger Protein 4 (RNF4) Interaktionspartner

  1. These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure.

  2. This paper identifies a nucleosome-targeting motif within the RNF4 RING domain that can bind DNA and thereby enables RNF4 to selectively ubiquitinate nucleosomal histones.

  3. fork collapse in Atr-deleted cells is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA-PLK1 pathway

  4. Rnf4 controls protein localization at DNA damage sites by integrating SUMOylation and ubiquitylation events.

  5. SUMO interacting motif is dispensable for PML (zeige PML Proteine) SUMOylation and interaction with RNF4 but is required for efficient PML (zeige PML Proteine) ubiquitination, recruitment of proteasome components within NBs (zeige NLRP2 Proteine) and proteasome-dependent degradation of PML (zeige PML Proteine) in response to AsO

  6. Rnf4 deficiency is embryonic lethal with higher levels of methylation in genomic DNA. Mechanistic studies show that RNF4 interacts with and requires the base excision repair enzymes TDG (zeige TDG Proteine) and APE1 (zeige APEX1 Proteine) for active demethylation.

  7. GC-rich (zeige RELB Proteine) elements flanking the transcription start site govern activation

  8. 1.6- and 3.0-kb transcripts originate from the same promoter, encode for the same protein and differ in the 3' UTR.

  9. RNF4 is a negative regulator of TRPS1 activity

  10. results suggest a role for small nuclear ring finger protein(SNURF/RNF4) in fetal germ cell development as well as in oocyte and granulosa cell maturation in an estrogen- and gonadotropin-regulated fashion

RNF4 Protein Überblick

Protein Überblick

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.

Alternative names and synonyms associated with RNF4

  • ring finger protein 4 (RNF4)
  • ring finger protein 4 (Rnf4)
  • ring finger protein 4 (LOC100348357)
  • AU018689 Protein
  • Gtrgeo8 Protein
  • SLX5 Protein
  • SNURF Protein

Bezeichner auf Proteinebene für Ring Finger Protein 4 Proteine (RNF4)

E3 ubiquitin ligase RNF4 , E3 ubiquitin-protein ligase RNF4 , small nuclear RING finger protein , gene trap ROSA b-geo 8 , SNURF , small nuclear ring finger protein , RING finger protein 4

GENE ID SPEZIES
6047 Homo sapiens
19822 Mus musculus
29274 Rattus norvegicus
100348357 Oryctolagus cuniculus
100735750 Cavia porcellus
692189 Sus scrofa
617018 Bos taurus
101110510 Ovis aries
610552 Canis lupus familiaris
422886 Gallus gallus
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