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Ring Finger Protein 14 (RNF14) is a binding partner for all TCF (zeige HNF4A Proteine)/LEF transcription factors.
ARA54 role in prostate carcinoma progression may in may involve function as androgen receptor (zeige AR Proteine) coactivator and focal adhesion protein
ARA54, might have dual in vivo roles functioning as both a direct coactivator and as an indirect mediator in AR function.
Dual functional roles for ARA54 as an AR coregulator directly and as a mediator for the suppressive effect of hnRNP A1 (zeige HNRNPA1 Proteine) indirectly.
mRNA expression of ARA54 correlates with that of cyclin D1 (zeige CCND1 Proteine) in human colon carcinoma cells, indicating that ARA54 is not only involved in the regulation of cyclin D1 (zeige CCND1 Proteine) expression in cultured cell lines but also in clinical cancer specimens.
Differential localization of ARA54 may play an important role in testicular development and spermatogenesis in humans.
RNF14 influences the expression of both mitochondrial and immune related genes
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
E3 ubiquitin-protein ligase RNF14
, androgen receptor associated protein 54
, androgen receptor-associated protein 54
, androgen receptor associated protein 54 (androgen receptor coactivator)
, triad2 protein
, TRIAD2 type I
, protein Triad2