Synaptojanin 1 Proteine (SYNJ1)

Bezeichnung:
Synaptojanin 1 Proteine (SYNJ1)
Auf www.antikoerper-online.de finden Sie aktuell 5 Synaptojanin 1 (SYNJ1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Synaptojanin 1 Antikörper (44) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 52 Synaptojanin 1 Produkte verfügbar.
Synonyme:
A930006D20Rik, AA675315, CG6562, Dmel\\CG6562, fb02f11, fi15a11, INPP5G, IPP, mKIAA0910, nrc, Synj, SYNJ1, wu:fb02f11, wu:fi15a11
alle Proteine anzeigen Gen GeneID UniProt
Ratte SYNJ1 SYNJ1 85238 Q62910
SYNJ1 8867 O43426
SYNJ1 104015  

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Weitere Proteine zu Synaptojanin 1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Synaptojanin 1 (SYNJ1) Interaktionspartner

  1. This study demonstrated that Synaptojanin, a protein with a known role in synaptic vesicle endocytosis, is phosphorylated at S1029 in vivo by the Minibrain (zeige DYRK1A Proteine) kinase. We further demonstrate that the phosphorylation status of Synaptojanin at S1029 differentially regulates its participation in the recycling of distinct synaptic vesicle pools.

  2. Mnb (zeige DYRK1A Proteine) is a synaptic kinase that promotes efficient synaptic vesicle recycling by Synj function at the neuromuscular junction.

  3. Findings imply that restoring the level of any one of these genes dap160/itsn1, synj/synj1, and nla/dscr1 (zeige RCAN1 Proteine) may reduce endocytic defects seen in DS.

  4. In the absence of synaptojanin or endophilin, vesicles undergo full fusion and re-formation.

Zebrafish Synaptojanin 1 (SYNJ1) Interaktionspartner

  1. Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments.

  2. This protein localized predominantly to cone photoreceptors. Using blastula stage transplantation experiments, study demonstrates that rods from mutants lacking SynJ1 develop normally and do not have the pronounced morphological defects detected in cones

  3. Synj1 is required for anchoring of ribbons, for vesicle maintenance, and for synaptic transmission at cone photoreceptor ribbon synapses.

  4. Synj1 is critical for retrieval of membrane in order to maintain the quantity, timing of fusion, and spontaneous release properties of synaptic vesicles at hair-cell ribbon synapses.

Human Synaptojanin 1 (SYNJ1) Interaktionspartner

  1. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses

  2. Thus, synaptojanin is essential for macroautophagy within presynaptic terminals, coupling protein turnover with synaptic vesicle cycling and linking presynaptic-specific autophagy defects to Parkinson's disease.

  3. SYNJ1 deficiency leads to early onset refractory seizures and progressive neurological decline.

  4. Mutations in SYNJ1 gene do not play a major role in early-onset or familial PD in our population.

  5. This study demonstrated that SYNJ1 was significantly higher in Down syndrome and correlated with several measures of Abeta (zeige APP Proteine). SYNJ1 was higher in down syndrome with Alzheimer disease and significantly higher than SYNJ1 in sporadic Alzheimer disease.

  6. This is the third reported family with autosomal recessive, early-onset parkinsonism associated with the SYNJ1 p.Arg258Gln mutation. This work contributes to the definition of the genetic and clinical aspects of PARK20.

  7. the clinical progression of the Italian siblings with SYNJ1-related early-onset atypical parkinsonism seems to present a more severe progression in the early stages

  8. Our data suggest that the previously reported Arg258Gln mutation in SYNJ1 is not a frequent cause of Parkinson disease

  9. This review presented that SYNJ1 in recessive forms of juvenile parkinsonism.

  10. Findings suggest that SYNJ1 mutation is responsible for the early-onset Parkinsonism phenotype probably due to deficiencies in its phosphatase activity and consequent impairment of its synaptic functions.

Cow (Bovine) Synaptojanin 1 (SYNJ1) Interaktionspartner

Mouse (Murine) Synaptojanin 1 (SYNJ1) Interaktionspartner

  1. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses

  2. a novel mechanism by which reduction of a PI(4,5)P2-degrading enzyme, synj1, improves amyloid-induced neuropathology and behavior deficits through accelerating cellular Abeta (zeige APP Proteine) clearance.

  3. These results implicate Pak5 (zeige PAK7 Proteine) in Pacsin1 (zeige PACSIN1 Proteine)- and Synaptojanin1-mediated synaptic vesicle trafficking.

  4. PI(4,5)P-to-PI4P conversion achieved by Synj1 at sites of high curvature may cooperate with dynamin (zeige DNM1 Proteine) to achieve membrane fission.

  5. synaptojanin 1 function is needed for the progression of recycling vesicles to the functional synaptic vesicle pool.

  6. PtdIns(4,5)P(2) dyshomeostasis caused by gene dosage imbalance for Synj1 may contribute to brain dysfunction and cognitive disabilities in down syndrome.

  7. Synaptojanin 1 functions in constitutive and triggered internalization of AMPA (zeige GRIA3 Proteine) receptors.

  8. Synaptojanin-1 is involved phosphatidylinositol metabolism in astrogliogenesis, but not in neurogenesis.

Synaptojanin 1 (SYNJ1) Protein Überblick

Protein Überblick

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Synaptojanin 1 (SYNJ1)

  • synaptojanin (synj)
  • synaptojanin 1 (synj1)
  • synaptojanin 1 (SYNJ1)
  • synaptojanin 1 (LOC100228100)
  • synaptojanin 1 (Synj1)
  • A930006D20Rik Protein
  • AA675315 Protein
  • CG6562 Protein
  • Dmel\\CG6562 Protein
  • fb02f11 Protein
  • fi15a11 Protein
  • INPP5G Protein
  • IPP Protein
  • mKIAA0910 Protein
  • nrc Protein
  • Synj Protein
  • SYNJ1 Protein
  • wu:fb02f11 Protein
  • wu:fi15a11 Protein

Bezeichner auf Proteinebene für Synaptojanin 1 Proteine (SYNJ1)

CG6562-PA , CG6562-PB , CG6562-PC , synj-PA , synj-PB , synj-PC , no optokinetic response c , synaptojanin-1 , synaptojanin 1 , synaptojanin 1, isoform 1 , synaptojanin-1-like , synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1 , synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 , inositol 5'-phosphatase (synaptojanin 1) , synaptojanin-1, polyphosphoinositide phosphatase , p150

GENE ID SPEZIES
37517 Drosophila melanogaster
337236 Danio rerio
473959 Pan troglodytes
100052605 Equus caballus
100137543 Papio anubis
100228100 Taeniopygia guttata
100395303 Callithrix jacchus
100487517 Xenopus (Silurana) tropicalis
100567389 Anolis carolinensis
85238 Rattus norvegicus
418498 Gallus gallus
8867 Homo sapiens
478403 Canis lupus familiaris
282087 Bos taurus
100328807 Oryctolagus cuniculus
104015 Mus musculus
100525664 Sus scrofa
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