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SMPD3 Proteine (SMPD3)

Bezeichnung:
Sphingomyelin Phosphodiesterase 3 Proteine (SMPD3)
Auf www.antikoerper-online.de finden Sie aktuell 8 Sphingomyelin Phosphodiesterase 3 (SMPD3) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMPD3 Antikörper (51) und SMPD3 Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 66 SMPD3 Produkte verfügbar.
Synonyme:
4631433G07Rik, AI427456, AW537966, cca1, fro, NSMASE2
alle Proteine anzeigen Gen GeneID UniProt
SMPD3 58994 Q9JJY3
SMPD3 94338 O35049
SMPD3 55512 Q9NY59

Weitere Synonyme anzeigen

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Weitere Proteine zu SMPD3 Interaktionspartnern

Mouse (Murine) Sphingomyelin Phosphodiesterase 3 (SMPD3) Interaktionspartner

  1. Study provides evidence that Smpd3 expression in both chondrocytes and osteoblasts is required for normal endochondral bone development.

  2. these results highlight the role of nSMase2 in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2 (zeige HAS2 Proteine)

  3. nSMase2 activation is required for the development of infection-induced diaphragm calpain activation and muscle weakness.

  4. These results suggest that OTC (zeige OTC Proteine) is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC (zeige OTC Proteine) supplementation.

  5. Src (zeige SRC Proteine) and p38 mitogen-activated protein kinase (zeige MAPK14 Proteine) activities are critical for regulating nSMase2 phosphorylation.

  6. Smpd3 was identified as a redox-sensitive enzyme, whose basal activity mediated changes in its oligomeric state.

  7. Data confirms a crucial pro-survival role for SMPD3 during embryonic development.

  8. Smpd3/nSMase2-ceramide-Akt (zeige AKT1 Proteine) signaling axis negatively regulates BMP-induced chondrocyte maturation.

  9. The H2O2-induced src (zeige SRC Proteine)/PDGFRbeta/SK1 (zeige SPHK1 Proteine) signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src (zeige SRC Proteine)/PDGFRbeta/SK1 (zeige SPHK1 Proteine).

  10. Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema.

Human Sphingomyelin Phosphodiesterase 3 (SMPD3) Interaktionspartner

  1. Overexpression of Smpd3 induced cytodifferentiation of HPDL (zeige HPDL Proteine) cells, which could be suppressed by an inhibitor of its protein product, nSMase2. In addition,Smpd3 harboring a SNP (rs145616324) showed no activity and failed to induce cytodifferentiation of HPDL (zeige HPDL Proteine) cells. Together, these findings suggest that Smpd3 plays an important role in the osteoblastic differentiation of HPDL (zeige HPDL Proteine) cells.

  2. low oxLDL concentration triggers sprouting angiogenesis that involves ROS (zeige ROS1 Proteine)-induced activation of the neutral sphingomyelinase-2/sphingosine kinase-1 (zeige SPHK1 Proteine) pathway, and is effectively inhibited by GW4869.

  3. nSMase2 is a novel p53 (zeige TP53 Proteine) target gene, regulated by the DNA damage pathway to induce cell growth arrest.

  4. These results suggest that OTC (zeige OTC Proteine) is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC (zeige OTC Proteine) supplementation.

  5. nSMase2 involvement in cellular processes including inflammatory signaling, exosome generation, cell growth, and apoptosis, which in turn play important roles in pathologies such as cancer metastasis, Alzheimer's disease

  6. SMPD3 plays an important role in the release of microRNAs into extracellular spaces.

  7. The data shows that nSMase3 acts as a signaling nSMase (zeige SMPD2 Proteine) in skeletal muscle that is essential for TNF (zeige TNF Proteine)-stimulated oxidant activity.

  8. This is the first report on the critical role of ceramide generated by nSMase2 in stem cell ciliogenesis and differentiation.

  9. We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (zeige SGMS1 Proteine)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS (zeige UGCG Proteine)) in the endometrium of endometriotic women.

  10. The H2O2-induced src (zeige SRC Proteine)/PDGFRbeta/SK1 signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src (zeige SRC Proteine)/PDGFRbeta/SK1.

SMPD3 Protein Überblick

Protein Überblick

Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF- kappa-B activation under inflammatory conditions.

Alternative names and synonyms associated with SMPD3

  • sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (SMPD3)
  • sphingomyelin phosphodiesterase 3, neutral (Smpd3)
  • sphingomyelin phosphodiesterase 3, neutral membrane (Smpd3)
  • 4631433G07Rik Protein
  • AI427456 Protein
  • AW537966 Protein
  • cca1 Protein
  • fro Protein
  • NSMASE2 Protein

Bezeichner auf Proteinebene für SMPD3

sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) , nSMase-2 , neutral sphingomyelinase 2 , neutral sphingomyelinase II , sphingomyelin phosphodiesterase 3 , confluent 3Y1 cell-associated 1 , confluent 3Y1 cell-associated protein 1 , nSMase2 , neutral sphingomyelin phosphodiesterase 3

GENE ID SPEZIES
415619 Gallus gallus
58994 Mus musculus
94338 Rattus norvegicus
55512 Homo sapiens
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