CRYM Proteine (CRYM)

Crystallin, mu Proteine (CRYM)
Auf finden Sie aktuell 9 Crystallin, mu (CRYM) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CRYM Antikörper (73) und CRYM Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 98 CRYM Produkte verfügbar.
CRYM, DFNA40, THBP, zgc:158843
alle Proteine anzeigen Gen GeneID UniProt
CRYM 1428 Q14894
CRYM 12971 O54983
CRYM 117024 Q9QYU4

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Am meisten referenzierte CRYM Proteine

  1. Human CRYM Protein expressed in Escherichia coli (E. coli) - ABIN666997 : Kim, Gasser, Wistow: mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
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Weitere Proteine zu CRYM Interaktionspartnern

Human Crystallin, mu (CRYM) Interaktionspartner

  1. These findings confirm that, mechanistically, ketimine reductase/CRYM acts as a classical imine reductase and may explain the finding of bound pyruvate in the crystallized protein.

  2. ketimine reductase is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain

  3. The expression of mu-crystallin was regulated through the AP-1 (zeige FOSB Proteine) site in the promoter.

  4. Its ketimine reductase activity is strongly inhibited by thyroid hormones.

  5. This is the first report linking hyperglycemia with thyroid hormone (zeige PTH Proteine) binding protein CRYM and suggests that the role of CRYM in diabetic complications should be further investigated.

  6. Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues

  7. CRYM is a novel androgen-regulated gene whose expression is elevated in prostate cancer but down-regulated in castration therapy-resistant tumors.

Mouse (Murine) Crystallin, mu (CRYM) Interaktionspartner

  1. The results demonstrated that Crym is a crucial regulator of muscle plasticity, controlling metabolic and contractile properties of myofibers, and thus the selective inactivation of Crym may be a potential therapeutic target for muscle-wasting diseases.

  2. Reduction of Crym expression in Huntington's disease (HD) could render striatal neurons more susceptible to mutant huntingtin (zeige HTT Proteine) suggesting that Crym may be a key determinant of the vulnerability of the striatum.

  3. CRYM expression increases and sustains the T3 responsiveness of genes in cells, especially with alteration of the pericellular T3 concentration.

  4. Comparison of the apo and NADPH forms reveals a rearrangement of the protein upon NADPH binding that reduces the degrees of freedom of several residues and traps the conformation of the binding pocket in a more T3 competent state.

  5. The expression of mu-crystallin was regulated through the AP-1 (zeige JUN Proteine) site in the promoter.

  6. CRYM plays an important role in the development of the second peak of murine EIU.

  7. Disruption of the CRYM gene decreases T(3) concentrations in tissues and serum without alteration of peripheral T(3) action in vivo.

CRYM Protein Überblick

Protein Überblick

Crystallins are separated into two classes and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CRYM

  • crystallin, mu (CRYM)
  • crystallin, mu (crym)
  • crystallin, mu (Crym)
  • CRYM Protein
  • DFNA40 Protein
  • THBP Protein
  • zgc:158843 Protein

Bezeichner auf Proteinebene für Crystallin, mu Proteine (CRYM)

crystallin, mu , mu-crystallin homolog , mu-crystallin homolog-like , mu-crystallin-like protein , NADP-regulated thyroid-hormone binding protein , ketimine reductase , thiomorpholine-carboxylate dehydrogenase , NADP-regulated thyroid-hormone-binding protein , CDK108

427008 Gallus gallus
479818 Canis lupus familiaris
697588 Macaca mulatta
742586 Pan troglodytes
791205 Danio rerio
8913325 Erwinia amylovora CFBP1430
100101313 Xenopus laevis
100125176 Xenopus (Silurana) tropicalis
100388738 Callithrix jacchus
100454622 Pongo abelii
100528988 Ictalurus punctatus
1428 Homo sapiens
12971 Mus musculus
117024 Rattus norvegicus
505167 Bos taurus
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