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Our results strengthen the evidence for the role of CRHR1 single nucleotide polymorphisms in major depressive disorder susceptibility and suggest that their effects may be modulated by sex and smoking status.
results confirm the role of TPH1 (zeige TPH1 ELISA Kits), TPH2 (zeige TDO2 ELISA Kits), 5HT2A, CRHR1 and ACP1 (zeige ACP1 ELISA Kits) variants in the risk of suicidal behavior.
This study found that the expressions of CRH (zeige CRH ELISA Kits) and CRHR1 were significantly higher in the epileptogenic tissues of patients with IS than in the control group.
The minor allele of rs17689918 was found to significantly increase risk for Panic Disorder in females after Bonferroni correction and furthermore decreased CRHR1 mRNA expression in human forebrains and amygdalae.the risk allele of rs17689918 led to less flight behavior during fear-provoking situations but rather increased anxious apprehension and went along with increased anxiety sensitivity.
Study showed that alterations in CRHR1 gene were associated with higher levels of IL-1beta (zeige IL1B ELISA Kits), and increased risk for suicide, reinforcing the importance of multifactorial interactions of biological markers for psychiatric disorders.
This study suggests that interactions between anandamide and CRF1 represent a fundamental molecular mechanism regulating amygdala function and anxiety.
This study demonstrated that several candidate SNPs in CRHR1 were associated with theta-Fz energy at a threshold of p < 0.05.
cardiac expression of CRFR1, CRF (zeige CRH ELISA Kits), and Ucn3 (zeige UCN3 ELISA Kits) genes is elevated in heart failure and may contribute to the activation of the CRF (zeige CRH ELISA Kits)/Ucn (zeige UCN ELISA Kits) system in these patients. A common variant within the CRFR1 gene and a novel CRFR1 splice variant may modulate CRFR1 expression and signaling.
there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.
This study showed that associations between BPD and haplotype combinations of the genes FKBP5 (zeige FKBP5 ELISA Kits) and CRHR1.
switch in G protein coupling for type 1 corticotropin-releasing factor (zeige CRH ELISA Kits) receptors promotes excitability in epileptic brains
Study characterized the influences of early-life stress on the developmental trajectory of hippocampal pyramidal neurons, and highlighted the critical role of CRHR1 in modulating these negative outcomes evoked by early-life stress.
the beneficial effects of CRFR1 antagonism seen in transgenic mice may be mechanistically linked to the modulation of oxidative stress pathways
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the elevated plus maze.
found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Excitability of genetically isolated CRF (zeige CRH ELISA Kits)-receptive (CRFR1) neurons in the central nucleus of the amygdala (CeA (zeige CEA ELISA Kits)) is potently enhanced by CRF (zeige CRH ELISA Kits) and that CRFR1 signaling in the CeA (zeige CEA ELISA Kits) is critical for discriminative fear
Study demonstrated that CRF1 receptor-deficiency prolongs whereas CRF2 receptor (zeige CRHR2 ELISA Kits)-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF (zeige CRH ELISA Kits) receptor subtypes in cognitive dysfunction associated with opiate withdrawal.
CRFR1, in a subset of AgRP (zeige AGRP ELISA Kits) neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
the cyclic AMP (zeige TMPRSS5 ELISA Kits) (cAMP) response of CRHR1 in physiologically relevant scenarios engages separate cAMP sources, involving the atypical soluble adenylyl cyclase (sAC (zeige ADCY10 ELISA Kits)) in addition to transmembrane adenylyl cyclases (tmACs).
Data suggest a physiologically relevant role for local corticotropin-releasing hormone (zeige CRH ELISA Kits) signaling towards shaping the neuronal circuitry within the mouse olfactory bulb.
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN (zeige UCN ELISA Kits), CRHR1 and CRHR2 (zeige CRHR2 ELISA Kits) and that UCN (zeige UCN ELISA Kits) plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 (zeige CRHR2 ELISA Kits) are expressed in the bovine adrenal gland.
results indicate that arginine vasopressin (zeige AVP ELISA Kits) receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3 (zeige AVPR1B ELISA Kits)]
CRF (zeige CRH ELISA Kits) is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective
CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 (zeige CRHR2 ELISA Kits) activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
The results of this study suggested that variation in CRHR1 may influence brain function before any childhood adversity and may be a diathesis for the interaction between CRHR1 genotypes and childhood trauma reported to affect human psychopathology
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346.
corticotropin releasing hormone receptor variant 1e
, corticotropin releasing hormone receptor variant 1g
, corticotropin-releasing factor receptor 1
, corticotropin-releasing factor type 1 receptor
, corticotropin-releasing hormone receptor 1
, seven transmembrane helix receptor
, corticotropin releasing factor receptor type 1
, CRH-R 1
, corticotrophin releasing hormone receptor 1
, corticotropin releasing hormone 1
, CRF 1 receptor
, corticotropin releasing hormone receptor type I
, corticotropin releasing hormone receptor 1
, corticotrophin-releasing factor type 1 alpha receptor