Adrenomedullin Proteine (ADM)

Bezeichnung:
Adrenomedullin Proteine (ADM)
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Synonyme:
ADM, AM, Ap, H39316, RATAP
alle Proteine anzeigen Gen GeneID UniProt
ADM 25026 P43145
ADM 133 P35318
ADM 11535 P97297

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Am meisten referenzierte Adrenomedullin Proteine

  1. Human Adrenomedullin Protein expressed in Human Cells - ABIN2004468 : Hao, Yu, Qi, Luo, Wang: The antifibrosis effect of adrenomedullin in human lung fibroblasts. in Experimental lung research 2011 (PubMed)

Weitere Proteine zu Adrenomedullin Interaktionspartnern

Human Adrenomedullin (ADM) Interaktionspartner

  1. Findings indicate the importance of cancer-associated fibroblasts (CAFs (zeige TBX1 Proteine))-derived adrenomedullin (AM) pathway in growth of breast carcinoma and in neovascularization by supplying and amplifying signals that are essential for pathologic angiogenesis.

  2. Mouse and human heart valves expressed mRNAs for the CRL (zeige IL31RA Proteine) ligands adrenomedullin (AM), adrenomedullin-2 (AM-2 (zeige ADM2 Proteine)) and calcitonin gene-related peptide (CGRP (zeige CALCA Proteine)) and for their receptor components, i.e., CRL (zeige IL31RA Proteine) and receptor-activity-modifying proteins 1-3.

  3. SHH (zeige SHH Proteine) acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells .

  4. Our findings showed that adrenomedullin expression increased in progression from benign endometrium to endometrial intraepithelial neoplasia and type-1 adenocarcinoma

  5. The levels of IL-8 (zeige IL8 Proteine), IL-12 (zeige IL12A Proteine), and adrenomedullin may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF (zeige SCN5A Proteine).

  6. Evidence show that ADM could affect the growth and differentiation of leukemia cells by modulating RAMPs/CRLR (zeige CALCRL Proteine) expression, PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) cascade and the ERK/MAPK (zeige MAPK1 Proteine) signaling pathway.

  7. A panel of three biomarkers (MR-proANP, PCT (zeige UROD Proteine), and MR-proADM) in patients presenting to the emergency unit with acute dyspnea provides information about the probability of acute heart failure, nonsurvival, and pneumonia.

  8. conclusion supplementation with selenium and coenzyme Q10 (zeige EIF2C2 Proteine) during four years resulted in less concentration of both copeptin (zeige AVP Proteine) and MR-proADM

  9. High Adrenomedullin expression is associated with Malignant Pleural Mesothelioma.

  10. Among adrenomedullin, CRP (zeige CRP Proteine), and PCT (zeige UROD Proteine), procalcitonin demonstrates the highest correlation with the severity of infection.

Mouse (Murine) Adrenomedullin (ADM) Interaktionspartner

  1. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2 (zeige ADM2 Proteine)) and calcitonin gene-related peptide (CGRP (zeige CALCA Proteine)) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.

  2. Findings demonstrated that Adrenomedullin (AM) was produced by synovial fibroblasts and macrophages in inflamed synovial tissue and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages.

  3. vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin

  4. It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility.

  5. Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice.

  6. These results indicate the AM-RAMP2 (zeige RAMP2 Proteine) system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth.

  7. Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.

  8. The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase (zeige NOX1 Proteine) probably by suppressing the local renin (zeige REN Proteine)-angiotensin system.

  9. Hypoxia upregulates expression of the Notch ligand Dll4 (zeige DLL4 Proteine) and increases Notch (zeige NOTCH1 Proteine) signaling in a process requiring the vasoactive hormone adrenomedullin.

  10. Adrenomedullin-RAMP2 (zeige RAMP2 Proteine) system is crucially involved in retinal angiogenesis.

Cow (Bovine) Adrenomedullin (ADM) Interaktionspartner

  1. Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR (zeige CALCRL Proteine), RAMP2 (zeige RAMP2 Proteine) and RAMP3 (zeige RAMP3 Proteine) were detected in cotyledonary villous and caruncular epithelial cells.

  2. The present study thus showed that neither leptin (zeige LEP Proteine) nor resistin (zeige RETN Proteine) affects the expression of endothelin-1 (zeige EDN1 Proteine) or adrenomedullin in bovine brain microvascular endothelial cells.

Pig (Porcine) Adrenomedullin (ADM) Interaktionspartner

  1. Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (zeige CALCRL Proteine) (calcitonin gene-related peptide (zeige CALCA Proteine) receptor; not adrenomedullin receptor (zeige GPR182 Proteine)).

  2. adrenomedullin prevented loss of cerebral autoregulation after fluid percussion injury in a sex-dependent and ERK MAPK (zeige MAPK1 Proteine)-dependent manner

Adrenomedullin (ADM) Protein Überblick

Protein Überblick

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.

Alternative names and synonyms associated with Adrenomedullin (ADM)

  • adrenomedullin (ADM)
  • adrenomedullin (adm)
  • adrenomedullin (Adm)
  • adrenomedullin (LOC100347461)
  • adrenomedullin (AMPP)
  • ADM Protein
  • AM Protein
  • Ap Protein
  • H39316 Protein
  • RATAP Protein

Bezeichner auf Proteinebene für Adrenomedullin Proteine (ADM)

adrenomedullin , ADM , preproadrenomedullin , pro-adrenomedullin

GENE ID SPEZIES
451021 Pan troglodytes
703305 Macaca mulatta
100135021 Xenopus (Silurana) tropicalis
25026 Rattus norvegicus
133 Homo sapiens
403817 Canis lupus familiaris
423042 Gallus gallus
11535 Mus musculus
100347461 Oryctolagus cuniculus
280713 Bos taurus
397195 Sus scrofa
100733203 Cavia porcellus
101103753 Ovis aries
100033857 Equus caballus
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