Islet Amyloid Polypeptide Proteine (IAPP)

Islet Amyloid Polypeptide Proteine (IAPP)
Auf finden Sie aktuell 7 Islet Amyloid Polypeptide (IAPP) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Islet Amyloid Polypeptide Antikörper (118) und Islet Amyloid Polypeptide Kits (78) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 240 Islet Amyloid Polypeptide Produkte verfügbar.
Amylin, DAP, IAP, LOC100230121
alle Proteine anzeigen Gen GeneID UniProt
IAPP 3375 P10997
IAPP 24476 P12969
IAPP 15874 P12968

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Weitere Proteine zu Islet Amyloid Polypeptide Interaktionspartnern

Human Islet Amyloid Polypeptide (IAPP) Interaktionspartner

  1. Data show that aluminum (Al3+) could inhibit islet amyloid polypeptide hIAPP(11-28) fibrillogenesis.

  2. The absence of BACE2 (zeige BACE2 Proteine) ameliorates glucose tolerance defects induced by IAPP overexpression in the beta-cell and promotes beta-cell survival.

  3. This study supports the elucidation of the structural basis of IAPP amyloid formation and highlights the extent of amyloid fibril polymorphism.

  4. Data suggest that a single GlcNAc residue at CTR (zeige CALCR Proteine) N130 (asparagine 130) is responsible for enhanced affinity of calcitonin (zeige CALCA Proteine) for CTR (zeige CALCR Proteine) ECD (zeige SHFM1 Proteine); the same appears to apply for enhanced affinity of amylin for RAMP2 (zeige RAMP2 Proteine)-CTR (zeige CALCR Proteine) ECD (zeige SHFM1 Proteine). [GlcNAc = N-acetylglucosamine; CTR (zeige CALCR Proteine) = calcitonin receptor (zeige CALCR Proteine); ECD (zeige SHFM1 Proteine) = extracellular domain; RAMP2 (zeige RAMP2 Proteine) = receptor (calcitonin) activity modifying protein 2 (zeige RAMP2 Proteine)].

  5. The kinetics of human amylin amyloid formation can be monitored by SYPRO-orange fluorescence and match the time course determined with thioflavin-T assays.

  6. effect of cholesterol on the amyloidogenicity of IAPP

  7. Chondroitin sulfate A has an intensive promotion effect on the fibrillation of human IAPP at the palmitoyloleoylphosphatidylcholine (POPC) membrane, which is larger than the total effect of Chondroitin sulfate A alone and POPC alone.

  8. C4BP (zeige C4BPA Proteine) protects beta-cells from IAPP cytotoxicity by modulating IAPP fibril formation extracellularly and also, after uptake by the cells, by enhancing cholesterol synthesis.

  9. beta-hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors.

  10. hA17-29 aggregate toxicity seems to be mediated by RAGE (zeige AGER Proteine) and p75-NGFR (zeige NGFR Proteine) receptors

Pig (Porcine) Islet Amyloid Polypeptide (IAPP) Interaktionspartner

Mouse (Murine) Islet Amyloid Polypeptide (IAPP) Interaktionspartner

  1. These data suggest participation by both soluble and fibrillar aggregates in IAPP-induced islet inflammation. IAPP-induced activation of TLR2 and secretion of IL-1 (zeige IL1A Proteine) may be important therapeutic targets to prevent amyloid-associated beta cell dysfunction.

  2. Hypothalamic amylin is transcriptionally regulated by leptin (zeige LEP Proteine), that it can act directly on ObRb (zeige LEPR Proteine) neurons in concert with leptin (zeige LEP Proteine), and that it regulates feeding.

  3. Matrix Metalloproteinase-9 (zeige MMP9 Proteine) Protects Islets from Amyloid-induced Toxicity.

  4. Data indicate that T-cell receptors that react to chromogranin A (ChgA (zeige CHGA Proteine)) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (zeige PRSS16 Proteine)).

  5. Study the physiologic actions of IAPP on pancreatic beta cells, which secrete this peptide together with insulin (zeige INS Proteine) upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP on beta cells.

  6. deletion of the DeltaN isoforms of p63 (zeige CKAP4 Proteine) or p73 (zeige ARHGAP24 Proteine) leads to metabolic reprogramming and regression of p53 (zeige TP53 Proteine)-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin (zeige INS Proteine) by the beta cells of the pancreas

  7. The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin, were investigated.

  8. studies have identified a novel TXNIP (zeige TXNIP Proteine)/miR (zeige MLXIP Proteine)-124a/FoxA2 (zeige FOXA2 Proteine)/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP (zeige TXNIP Proteine) and IAPP

  9. MMP-9 (zeige MMP9 Proteine) constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP.

  10. Data suggest that amylin and leptin (zeige LEP Proteine) play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress.

Islet Amyloid Polypeptide (IAPP) Protein Überblick

Protein Überblick

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Alternative names and synonyms associated with Islet Amyloid Polypeptide (IAPP)

  • islet amyloid polypeptide (LOC100230121)
  • islet amyloid polypeptide (IAPP)
  • islet amyloid polypeptide (Iapp)
  • islet amyloid polypeptide-like (LOC100520838)
  • Amylin Protein
  • DAP Protein
  • IAP Protein
  • LOC100230121 Protein

Bezeichner auf Proteinebene für IAPP

islet amyloid polypeptide , Islet amyloid polypeptide (diabetes-associated peptide; amylin) , amylin , diabetes-associated peptide , insulinoma amyloid peptide , DAP , amyloid protein

100230121 Taeniopygia guttata
3375 Homo sapiens
751513 Felis catus
100381251 Sus scrofa
24476 Rattus norvegicus
100135550 Cavia porcellus
15874 Mus musculus
100009489 Oryctolagus cuniculus
403909 Canis lupus familiaris
100138011 Bos taurus
101120402 Ovis aries
396362 Gallus gallus
101832022 Mesocricetus auratus
100520838 Sus scrofa
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