Claudin 16 Proteine (CLDN16)

Bezeichnung:
Claudin 16 Proteine (CLDN16)
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Synonyme:
claudin-16, CLDN16, HOMG3, Pcln1
alle Proteine anzeigen Gen GeneID UniProt
CLDN16 10686 Q9Y5I7
CLDN16 114141 Q925N4
Ratte CLDN16 CLDN16 155268 Q91Y55

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Weitere Proteine zu Claudin 16 Interaktionspartnern

Human Claudin 16 (CLDN16) Interaktionspartner

  1. Data suggest that Pdzrn3 (zeige PDZRN3 Proteine) mediates endocytosis of dephosphorylated CLDN16 and represents an important component of CLDN16-trafficking machinery in renal tube epithelial cells. (Pdzrn3 (zeige PDZRN3 Proteine) = PDZ domain containing RING finger 3 (zeige PDZRN3 Proteine) protein; CLDN16 = claudin 16)

  2. detected a novel mutation in CLDN16 for the first time. The clinical and genetic findings from this study will help to expand the understanding of this rare disease, FHHNC

  3. claudin-16 gene (CLDN16) mutations result in amelogenesis imperfect.

  4. CLDN16 mutations are associated with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis.

  5. 1,25(OH)2 VitD transcriptionally inhibits renal claudin-16 expression by a mechanism sensitive to CaSR (zeige CASR Proteine) and Mg(2 (zeige MUC7 Proteine)+).

  6. A novel CLDN16 mutation has been identified in a large consanguineous family with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis.

  7. These results suggest that STX8 (zeige STX8 Proteine) mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney.

  8. Six different mutations of CLDN16 were detected (five missense and one nonsense); three of the missense mutations were previously unknown (p.Cys80Tyr, p.Lys183Glu, and p.Gly233Arg).

  9. A novel mutation of CLDN16 gene is responsible for familial hypomagnesaemia in Turkish children.

  10. Claudin-16 plays a role beyond that of an initial metastasis repressor in breast cancer.

Cow (Bovine) Claudin 16 (CLDN16) Interaktionspartner

  1. Claudin-16 sequences were not usually amplified from a small number of sperm cells (< or =10 cells) but claudin-16 DNA sequences were occasionally detected when a large number of sperm cells (> or =50 cells) were present.

  2. Renal lesions in Japanese Black cattle are not necessarily associated with homozygous deletion of the CL-16 gene.

Mouse (Murine) Claudin 16 (CLDN16) Interaktionspartner

  1. claudin-16 gene (CLDN16) mutations result in amelogenesis imperfect.

  2. 1,25(OH)2 VitD transcriptionally inhibits renal claudin-16 expression by a mechanism sensitive to CaSR (zeige CASR Proteine) and Mg(2 (zeige MCOLN1 Proteine)+).

  3. Mg(2 (zeige MCOLN1 Proteine)+)-loaded animals displayed hypermagnesemia with increasing urine Mg(2 (zeige MCOLN1 Proteine)+)/Ca(2 (zeige CA2 Proteine)+) levels paralleled by a decrease in claudin-16 protein and mRNA in the kidney.

  4. data suggest that claudin-16 forms a non-selective paracellular cation channel (zeige TRPV1 Proteine), rather than a selective Mg(2 (zeige MCOLN1 Proteine)+)/Ca(2 (zeige CA2 Proteine)+) channel as previously proposed

  5. Perturbation in salt and acid-base metabolism in CLDN16 knockout mice has its origin in the defective cation permeability selectivity of the thick ascending limb of the nephron.

  6. Insights into driving forces and paracellular permeability from claudin-16 knockdown mouse

  7. Claudin-16 and claudin-19 (zeige CLDN19 Proteine) interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium.

Claudin 16 (CLDN16) Protein Überblick

Protein Überblick

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.

Alternative names and synonyms associated with Claudin 16 (CLDN16)

  • claudin 16 (CLDN16)
  • claudin 16 (Cldn16)
  • claudin 16 (LOC100356384)
  • claudin-16 Protein
  • CLDN16 Protein
  • HOMG3 Protein
  • Pcln1 Protein

Bezeichner auf Proteinebene für Claudin 16 Proteine (CLDN16)

claudin 16 , PCLN-1 , claudin-16 , hypomagnesemia 3, with hypercalciuria and nephrocalcinosis , paracellin-1 , CL-16 , H59D2a protein

GENE ID SPEZIES
429147 Gallus gallus
740268 Pan troglodytes
10686 Homo sapiens
608218 Canis lupus familiaris
100302019 Sus scrofa
282184 Bos taurus
114141 Mus musculus
155268 Rattus norvegicus
100356384 Oryctolagus cuniculus
101105382 Ovis aries
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