IFT88 Proteine (IFT88)

Bezeichnung:
Intraflagellar Transport 88 Homolog (Chlamydomonas) Proteine (IFT88)
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Synonyme:
146590_s_at, AW552028, CG4137, CG12548, CG14465, CG15190, D13S1056E, DAF19, Dmel\\CG12548, flexo, fxo, hTg737, IFT88, nomp, NOMPB, orpk, osm-5, polaris, TG737, Tg737Rpw, TgN737Rpw, TTC10
alle Proteine anzeigen Gen GeneID UniProt
IFT88 21821 Q61371
IFT88 8100 Q13099
Ratte IFT88 IFT88 305918  

Weitere Synonyme anzeigen

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Weitere Proteine zu IFT88 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Intraflagellar Transport 88 Homolog (Chlamydomonas) (IFT88) Interaktionspartner

  1. NOMPB is required for the assembly of sensory cilia but not for the extension or function of the sperm flagellum.

Mouse (Murine) Intraflagellar Transport 88 Homolog (Chlamydomonas) (IFT88) Interaktionspartner

  1. Tg737 regulates a Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)/Snail (zeige SNAI1 Proteine)-HNF4alpha (zeige HNF4A Proteine) negative feedback circuit, thereby blocking EMT (zeige ITK Proteine) and the malignant transformation of liver stem cells to liver cancer stem cells.

  2. genetically ablated Kif3a, Ift88, and Ttc21b in a series of specific spatiotemporal domains. The resulting phenotypes allow us to draw several conclusions. First, we conclude that the Ttc21b cortical phenotype is not due to the activity of Ttc21b within the brain itself

  3. In order to evaluate the function of IFT88 in regulating craniofacial development, we generated Wnt1 (zeige WNT1 Proteine)-Cre;Ift88fl/fl mice to eliminate Ift88 specifically in cranial neural crest (CNC) cells. Wnt1 (zeige WNT1 Proteine)-Cre;Ift88fl/flpups died at birth due to severe craniofacial defects including bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme

  4. IFT88 influences chondrocyte actin organization and biomechanics.

  5. These data indicate that TGF-beta (zeige TGFB1 Proteine) regulates Ift88 gene expression at least in part via posttrascriptional manner.

  6. Results suggest that EGF (zeige EGF Proteine) exerts mitogenic effects in the orpk cilia (-) cells via activation of growth-associated amiloride-sensitive NHEs and ERK (zeige EPHB2 Proteine).

  7. We propose that Ift88 and primary cilia regulate expression of Sfrp5 (zeige SFRP5 Proteine) and Wnt (zeige WNT2 Proteine) signaling pathways in growth plate via regulation of Ihh (zeige IHH Proteine) signaling.

  8. Knockout of Bbs7 (zeige BBS7 Proteine) combined with a hypomorphic Ift88 allele (orpk as a model for Shh (zeige SHH Proteine) dysfuction) results in embryonic lethality with e12.5 embryos having exencephaly, pericardial edema, cleft palate and abnormal limb development.

  9. Data show that IFT88 is present in the Golgi of spermatids, that the microtubule-associated golgin GMAP210 and IFT88 participate in acrosome, HTCA, and tail biogenesis.

  10. Epidermal cilia function was analyzed using conditional alleles of the ciliogenic genes Ift88 and Kif3a (zeige KIF3A Proteine).

Human Intraflagellar Transport 88 Homolog (Chlamydomonas) (IFT88) Interaktionspartner

  1. MiR (zeige MLXIP Proteine)-548a-5p negatively regulates the tumor inhibitor gene Tg737 and promotes tumorigenesis in vitro and in vivo, indicating its potential as a novel therapeutic target for hepatocellular carcinoma.

  2. subtle regulation of IFT and associated cilia structure, tunes the wnt (zeige WNT2 Proteine) response controlling stem cell differentiation.

  3. this work suggests that Tg737 is involved in the invasion and migration of hepatoma cells under hypoxia, with the involvement of the polycystin-1 (zeige PKD1 Proteine), IL-8 (zeige IL8 Proteine), and TGF-beta1 (zeige TGFB1 Proteine) signaling pathway

  4. A mutation in IFT88 causes a hitherto unknown human ciliopathy.

  5. Data show that IFT88 depletion induces mitotic defects in human cultured cells, in kidney cells from the IFT88 mouse mutant Tg737(orpk) and in zebrafish embryos.

  6. The results indicate that loss of heterozygosity of the tumor suppressor gene Tg737 may play an important role in the carcinogenetic mechanism of liver cancer stem cells.

  7. IFT88 is a centrosomal protein regulating G1-S transition in non-ciliated cells.

IFT88 Protein Überblick

Protein Überblick

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with IFT88

  • intraflagellar transport 88 homolog (Chlamydomonas) (IFT88)
  • intraflagellar transport 88 homolog (Chlamydomonas) (LOC100229127)
  • intraflagellar transport 88 homolog (ift88)
  • intraflagellar transport protein 88 homolog (LOC100518926)
  • intraflagellar transport protein 88 homolog (LOC100549198)
  • intraflagellar transport protein 88 homolog (LOC100640298)
  • intraflagellar transport protein 88 homolog (LOC100646898)
  • no mechanoreceptor potential B (nompB)
  • intraflagellar transport 88 (Ift88)
  • intraflagellar transport 88 homolog (Chlamydomonas) (Ift88)
  • 146590_s_at Protein
  • AW552028 Protein
  • CG4137 Protein
  • CG12548 Protein
  • CG14465 Protein
  • CG15190 Protein
  • D13S1056E Protein
  • DAF19 Protein
  • Dmel\\CG12548 Protein
  • flexo Protein
  • fxo Protein
  • hTg737 Protein
  • IFT88 Protein
  • nomp Protein
  • NOMPB Protein
  • orpk Protein
  • osm-5 Protein
  • polaris Protein
  • TG737 Protein
  • Tg737Rpw Protein
  • TgN737Rpw Protein
  • TTC10 Protein

Bezeichner auf Proteinebene für IFT88

intraflagellar transport protein 88 homolog , intraflagellar transport 88 homolog (Chlamydomonas) , CG12548-PA , CG12548-PC , nompB-PA , nompB-PC , TPR repeat protein 10 , intraflagellar transport 88 homolog , recessive polycystic kidney disease protein Tg737 , tetratricopeptide repeat domain 10 , tetratricopeptide repeat protein 10 , tgN(Imorpk)737Rpw , transgene insert site 737, insertional mutation, polycystic kidney disease , polaris homolog , probe hTg737 (polycystic kidney disease, autosomal recessive) , recessive polycystic kidney disease protein Tg737 homolog

GENE ID SPEZIES
514177 Bos taurus
100229127 Taeniopygia guttata
100305317 Oncorhynchus mykiss
100380476 Salmo salar
100518926 Sus scrofa
100549198 Meleagris gallopavo
100592735 Nomascus leucogenys
100640298 Amphimedon queenslandica
100646898 Bombus terrestris
35414 Drosophila melanogaster
21821 Mus musculus
8100 Homo sapiens
477345 Canis lupus familiaris
305918 Rattus norvegicus
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