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WISP2 Proteine (WISP2)

Bezeichnung:
WNT1 Inducible Signaling Pathway Protein 2 Proteine (WISP2)
Auf www.antikoerper-online.de finden Sie aktuell 19 WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen WISP2 Antikörper (74) und WISP2 Kits (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 113 WISP2 Produkte verfügbar.
Synonyme:
Ccn5, Crgr4, CT58, CTGF-L, Ctgfl, MGC84196, Rcop1, WISP2
alle Proteine anzeigen Gen GeneID UniProt
WISP2 8839 O76076
WISP2 22403 Q9Z0G4
WISP2 29576 Q9JHC6

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Weitere Proteine zu WISP2 Interaktionspartnern

Zebrafish WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Interaktionspartner

  1. One paralog of mammalian wisp2 was found in zebrafish.

Human WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Interaktionspartner

  1. Studies indicate that the CYR61 (zeige CYR61 Proteine) CTGF (zeige CTGF Proteine) NOV (zeige NOV Proteine) matricellular proteins (CCN family of proteins) comprises the members CCN1 (zeige CCNA2 Proteine), CCN2 (zeige CTGF Proteine), CCN3 (zeige NOV Proteine), CCN4 (zeige WISP1 Proteine), CCN5 and CCN6 (zeige WISP3 Proteine) and have been identified in various types of cancer.

  2. Report opposing effects of CCN2 (zeige CTGF Proteine) and CCN5 on fibroblast proliferation and transdifferentiation induced by TGF-beta (zeige TGFB1 Proteine).

  3. Serum WISP2 correlated directly with fatty acid binding protein 4. Serum SFRP5 (zeige SFRP5 Proteine) did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (zeige SFRP5 Proteine) (p<5x10(-6) as compared to both PCOS groups).

  4. Activation of CCN5 may have the therapeutic potential to kill triple-negative breast cancer.

  5. WISP2 has a role in regulating tumor cell susceptibility through EMT (zeige ITK Proteine) by inducing the TGF-beta (zeige TGFB1 Proteine) signaling pathway, KLF-4 (zeige KLF4 Proteine) expression and miR-7 (zeige LILRB1 Proteine) inhibition.

  6. overexpression of FGFBP1 (zeige FGFBP1 Proteine) or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.

  7. Loss of WISP2 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype.

  8. We demonstrate that the overexpression of CCN5 in lung fibroblasts suppresses the upregulation in the expression of alpha-SMA (zeige SMN1 Proteine) and collagen induced by CCN2 (zeige CTGF Proteine).

  9. WISP2 exerts dual actions in mesenchymal precursor cells; secreted WISP2 activates canonical WNT (zeige WNT2 Proteine) and maintains the cells in an undifferentiated state, whereas cytosolic WISP2 regulates adipogenic commitment.

  10. Regulation of invasion by WISP2 may involve the WNT (zeige WNT2 Proteine) signalling pathway.

Mouse (Murine) WNT1 Inducible Signaling Pathway Protein 2 (WISP2) Interaktionspartner

  1. Data suggest that CCN5, minimally expressed in unstimulated islet beta-cells, is strongly and directly induced by Igf1 (insulin-like growth factor I (zeige IGF1 Proteine)); overexpression of CCN5 stimulates cell proliferation and inhibits streptozotocin-induced apoptosis.

  2. These results suggested that secreted Wisp2/CCN5 induces Akt (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine) phosphorylation via integrins, and consequently facilitates neurite formation and conferred resistance to apoptosis.

  3. CCN2 (zeige CTGF Proteine) is pro-hypertrophic and -fibrotic, whereas CCN5 is anti-hypertrophic and -fibrotic.

  4. Although WISP-2 is a downstream protein of Wnt (zeige WNT2 Proteine) signaling, the role of WISP-2 on adipocyte differentiation may be marginal, at least in this in vitro culture model.

WISP2 Protein Überblick

Protein Überblick

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Alternative names and synonyms associated with WISP2

  • WNT1 inducible signaling pathway protein 2 (WISP2)
  • WNT1 inducible signaling pathway protein 2 (wisp2)
  • WNT1 inducible signaling pathway protein 2 (Wisp2)
  • Ccn5 Protein
  • Crgr4 Protein
  • CT58 Protein
  • CTGF-L Protein
  • Ctgfl Protein
  • MGC84196 Protein
  • Rcop1 Protein
  • WISP2 Protein

Bezeichner auf Proteinebene für WISP2

WNT1 inducible signaling pathway protein 2 , Wnt-1 inducible-signaling pathway protein 2 , WNT1 inducible signaling pathway 2 , zWISP2-c23 , CCN family member 5 , WISP-2 , WNT1-inducible-signaling pathway protein 2 , connective tissue growth factor-like protein , connective tissue growth factor-related protein 58 , wnt-1 signaling pathway protein 2 , CTGF-L , CCN family protein COP-1

GENE ID SPEZIES
419192 Gallus gallus
444655 Xenopus laevis
458271 Pan troglodytes
610928 Canis lupus familiaris
100007759 Danio rerio
8839 Homo sapiens
22403 Mus musculus
29576 Rattus norvegicus
534658 Bos taurus
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