anti-Hyaluronan Synthase 2 (HAS2) Antikörper

anti-Hyaluronan Synthase 2 Antikörper (HAS2)
Auf finden Sie aktuell 57 Hyaluronan Synthase 2 (HAS2) Antikörper von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Hyaluronan Synthase 2 Kits (20) und Hyaluronan Synthase 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 83 Hyaluronan Synthase 2 Produkte verfügbar.
DG42, Has2, XHas2
Alle Antikörper anzeigen Gen GeneID UniProt
HAS2 15117 P70312
Anti-Ratte HAS2 HAS2 25694 O35776
HAS2 3037 Q92819

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Am meisten referenzierte anti-Hyaluronan Synthase 2 Antikörper

  1. Human Polyclonal HAS2 Primary Antibody für FACS, IHC (p) - ABIN651874 : Simpson, Wilson, Furcht, Spicer, Oegema, McCarthy: Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 5 Referenzen für 651874

  2. Human Monoclonal HAS2 Primary Antibody für ICC, IHC - ABIN1098124 : Okuda, Kobayashi, Xia, Watabe, Pai, Hirota, Xing, Liu, Pandey, Fukuda, Modur, Ghosh, Wilber, Watabe: Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. in Cancer research 2012 (PubMed)
    Zeige alle 2 Referenzen für 1098124

Weitere Antikörper gegen Hyaluronan Synthase 2 Interaktionspartner

Zebrafish Hyaluronan Synthase 2 (HAS2) Interaktionspartner

  1. Fgf signaling is required early, from 6 to 10h pf,for has2 activation. Loss of has2 results inthe loss of the chondrogenic program resulting in postchordal neurocranial defects in Fgf loss-of-function embryos. Shh (zeige SHH Antikörper) is not essential for this early activation of has2.

  2. propose here a rather unique role of Med10 (zeige MED10 Antikörper) in orchestrating cardiac valve formation by mediating Foxn4 (zeige FOXN4 Antikörper) dependent tbx2b transcription, expression of Has2 and subsequently proper development of the cardiac jelly

  3. identify Npnt (zeige NPNT Antikörper) as a novel upstream regulator of Bmp4 (zeige BMP4 Antikörper)-Has2 signaling that plays a crucial role in AV canal differentiation

  4. MiR-23 is both necessary and sufficient for restricting the number of endocardial cells that differentiate into endocardial cushion cells by inhibiting Has2 and extracellular hyaluronic acid production.

  5. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5 (zeige TBX5 Antikörper), tbx20 (zeige TBX20 Antikörper), and has2 in the hear

Mouse (Murine) Hyaluronan Synthase 2 (HAS2) Interaktionspartner

  1. Expression of the innate immune receptor Toll-like receptor 4 (TLR4 (zeige TLR4 Antikörper)) and the extracellular matrix glycosaminoglycan hyaluronan (HA) on type 2 alveolar epithelial cells (AEC@2) are important for AEC2 renewal, repair of lung injury and limiting the extent of fibrosis. Either deletion of TLR4 (zeige TLR4 Antikörper) or HA synthase 2 in surfactant-protein-C (zeige SFTPC Antikörper)-positive AEC2s leads to impaired renewal capacity, severe fibrosis and mortality.

  2. Has2 mRNA was expressed in the surrounding mesenchyme from E12.0 to 18.0 in both molar and incisor tooth germs, but disappeared after birth.

  3. the ineffective repair of injured cartilage in Has1 (zeige HAS1 Antikörper)(-/-) joints can be at least partly explained by the markedly enhanced expression of particular genes in pathways linked to ECM (zeige MMRN1 Antikörper) turnover, IL-17 (zeige IL17A Antikörper)/IL-6 (zeige IL6 Antikörper) cytokine signaling, and apoptosis.

  4. these results highlight the role of nSMase2 (zeige SMPD3 Antikörper) in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2

  5. mir (zeige MLXIP Antikörper)-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.

  6. Has2 expression and hyaluronan produced at the tips of epithelial cells play a critical role in driving tubulogenesis and branching in vitro.

  7. Hyaluronan synthase 2 has a role in protecting skin fibroblasts against apoptosis induced by environmental stress

  8. Stimulation with LPS (zeige TLR4 Antikörper) caused rapid increases in versican (zeige Vcan Antikörper) mRNA and protein, a rapid increase in Has1 (zeige HAS1 Antikörper) mRNA, and concomitant inhibition of hyaluronidases 1 and 2, the major hyaluronan degrading enzymes

  9. This study demonistrated that Has2 expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.

  10. This study identifies Has2 as a novel downstream target of Shh (zeige SHH Antikörper) signaling required for joint patterning and chondrogenesis.

Human Hyaluronan Synthase 2 (HAS2) Interaktionspartner

  1. The present data reveal a selective up-regulation of HAS2 expression by extracellular Uridine Triphosphate, which is likely to contribute to the previously reported rapid activation of hyaluronan metabolism in response to tissue trauma or ultraviolet radiation.

  2. HAS2 and HAS3 (zeige HAS3 Antikörper) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (zeige NPS Antikörper) and NM.

  3. HAS2 has been proposed to be a target for therapeutic intervention in cancer. Our findings suggested a possible antagonistic role of androgen receptor (AR (zeige AR Antikörper)) pathway on HAS2 function.

  4. HAS-2 gene silencing may inhibit proliferation and promote apoptosis in the MCF-7 human breast cancer cell line.

  5. Our study establishes HAS2-mediated HA synthesis as a driver of growth of bladder cancer with low AGL (zeige AGL Antikörper) and provides preclinical rationale for personalized targeting of HAS2/HA signaling in patients with low amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (zeige AGL Antikörper) -expressing tumors.

  6. HAS2-HA system influences the biological characteristics of human breast cancer cells

  7. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199 (zeige KIAA1199 Antikörper)) and HA Synthases in Growth Factor-stimulated Fibroblasts.

  8. Our study identified HAS2 as a novel candidate gene for susceptibility to adult asthma.

  9. In contrast to other carcinoma subtypes, HAS2 expression was observed in up to 72.7% of metaplastic carcinomas of breast, a carcinoma subtype related to the epithelial-mesenchymal transition.

  10. transcriptional regulation of the HAS and HAS2-antisense RNA 1 genes, was analyzed.

Xenopus laevis Hyaluronan Synthase 2 (HAS2) Interaktionspartner

  1. In the absence of XHas2, early myoblasts underwent apoptosis, failing to complete their muscle differentiation programme. XHas2 activity is also required for migration of hypaxial muscle cells and trunk neural crest cells (NCC (zeige SLC12A3 Antikörper)).

Hyaluronan Synthase 2 (HAS2) Antigen-Profil

Beschreibung des Gens

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Alternative names and synonyms associated with Hyaluronan Synthase 2 (HAS2)

  • hyaluronan synthase 2 (has2) Antikörper
  • hyaluronan synthase 2 (HAS2) Antikörper
  • hyaluronan synthase 2 (LOC100228837) Antikörper
  • hyaluronan synthase 2 (Has2) Antikörper
  • hyaluronan synthase 2 (SHAS2) Antikörper
  • DG42 Antikörper
  • Has2 Antikörper
  • XHas2 Antikörper

Bezeichner auf Proteinebene für HAS2

hyaluronan synthase 2 , hyaluronic acid synthase 2 , HA synthase 2 , hyaluronan synthase homolog , hyaluronate synthase 2 , CHAS2 , xHAS2

260350 Danio rerio
472850 Pan troglodytes
482032 Canis lupus familiaris
100008626 Oryctolagus cuniculus
100009708 Equus caballus
100145711 Xenopus (Silurana) tropicalis
100228837 Taeniopygia guttata
15117 Mus musculus
25694 Rattus norvegicus
3037 Homo sapiens
281220 Bos taurus
395594 Gallus gallus
397120 Sus scrofa
399146 Xenopus laevis
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