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These studies provide evidence that a signaling pathway involving agrin, Fgfs and Shh (zeige SHH Proteine) may be a critical target of ethanol exposure during zebrafish embryogenesis.
Agrin expression and function may be a target of ethanol exposure during embryogenesis.
Agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish.
identificaton of agrin, a component of neonatal extracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts
The presence of C-terminal fragment of agrin (CAF (zeige LAMA2 Proteine)) in urine suggests either glomerular filtration or secretion into urine.
Agrin strongly promotes chondrocyte differentiation and cartilage formation in vivo.
Reveal novel roles for APP (zeige APP Proteine) in regulating neuromuscular synapse formation through hetero-oligomeric interaction with LRP4 (zeige CORIN Proteine) and agrin and thereby provide new insights into the molecular mechanisms that govern NMJ formation and maintenance.
Agrin is frequently upregulated and important for oncogenic property of hepatocellular carcinoma.
agrin contributes to barrier characteristics of brain endothelium.
NMJs in agrin-deficient mice rapidly disappear after birth. Agrin is essential for postnatal NMJ maintenance, but not for their embryonic formation, and also for the postnatal, but not prenatal, midmuscle localization of postsynaptic specializations.
reviews the evidence that agrin regulates synapse development, plasticity and signaling in the brain and discusses the evidence for the proposed mechanisms
Using gamma-secretase drug inhibitors and presenilin mutants in embryonic fibroblasts, we found that a mature gamma-secretase complex was required to repress neurotrypsin (zeige PRSS12 Proteine) expression and agrin cleavage.
Neural agrin slows the degradation of surface AChR in cultured muscle cellsb via phosphorylation of the AChR beta (zeige CHRNB1 Proteine) subunit (zeige POLG Proteine) at Y390, stabilizing AChR at developing synapses & adult neuromuscular junctions.
Agrin promotes oncogenesis through YAP (zeige YAP1 Proteine)-dependent transcription.
Knockdown of agrin and perlecan (zeige HSPG2 Proteine) promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin.
Among 42 hip fractured patients (age 83.7+/-8.6 years, 76.2% women), sarcopenia was diagnosed in 7 individuals (16.7%). Serum C-terminal agrin fragment (CAF (zeige KAT2B Proteine)) levels were significantly higher in sarcopenic relative to non-sarcopenic patients.
In patients suffering from severe sepsis and septic shock, serum levels of C-terminal agrin fragment were significantly associated with kidney function and the need for renal replacement therapy and were not influenced by severe septic conditions.
MuSK (zeige MUSK Proteine) myasthenia gravis IgG4 disrupts the interaction of LRP4 (zeige LRP4 Proteine) with MuSK (zeige MUSK Proteine) but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters
these observations indicate that agrin is another autoantigen in patients with MG and agrin autoantibodies may be pathogenic through inhibition of agrin/LRP4 (zeige LRP4 Proteine)/MuSK (zeige MUSK Proteine) signaling at the NMJ.
Five new recessive mutations in the gene encoding agrin are identified in patients with congenital myasthenic syndrome.
study identifies a spontaneous agrin mutation that reduces the ability of z+ agrin to activate MuSK (zeige MUSK Proteine) and induce AChR clustering; this results in a severe congenital myasthenic syndrome in the patient, with both pre- and postsynaptic defects at the neuromuscular junction
Dynamics of expression patterns of agrin in human glioblastoma
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found.
, agrin proteoglycan
, heparan sulfate proteoglycan