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A gene-expression-based neural code for food abundance that modulates lifespan includes daf-7 that primarily regulates gene-expression variability, while tph-1 primarily regulates the dynamic range of gene-expression responses.
tph-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans
results confirm the role of TPH1, TPH2 (zeige TDO2 ELISA Kits), 5HT2A, CRHR1 (zeige CRHR1 ELISA Kits) and ACP1 (zeige ACP1 ELISA Kits) variants in the risk of suicidal behavior.
Tryptophan Hydroxylase 1 Variant rs1800532 is associated with Suicide Attempt in Serbian Psychiatric Patients.
This study demonstrates that both TPH1 and TPH2 (zeige TDO2 ELISA Kits) are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development.
Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations. Investigated A218C polymorphism in 109 suicide attempters and 98 healthy controls. Our results provide evidence that A allele of TPH1 A218C polymorphism may be associated with suicidal behavior in Turkish population
The regulatory domain of isoform 1 of tryptophan hydroxylase was expressed and purified; mutagenesis of Cys64 was required to prevent formation of disulfide-linked dimers.
Associations between serotonin transporter (zeige SLC6A4 ELISA Kits) gene and tryptophan hydroxylase 1 polymorphisms and several Temperament and Character Inventory dimensions and subdimensions were revealed in subjects with bipolar disorder.
there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR (zeige SLC6A4 ELISA Kits) S+ gene polymorphisms in opiate-dependent, but not in alcohol-dependent patients.
Polymorphisms in the TPH1 gene may be represented by diminished activity in lateral areas of the PFC (zeige CFP ELISA Kits) underlying response inhibition.
Decoy receptor 3 (zeige TNFRSF6B ELISA Kits) regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts
TPH1 is functionally expressed in human coronary artery smooth muscle cells.
Prolactin (zeige PRL ELISA Kits)-induced Tph1 expression.
Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin (zeige INS ELISA Kits) resistance and nonalcoholic fatty liver disease (NAFLD (zeige TSC2 ELISA Kits)) while exhibiting greater energy expenditure by brown adipose tissue.
Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.
ZBP-89 (zeige ZNF148 ELISA Kits) directly binds to the Tph1 promoter, which is required for its basal and butyrate-inducible expression.
TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT (zeige DDC ELISA Kits) is pivotal in AAI and lack of 5-HT (zeige DDC ELISA Kits) leads to impaired Th2 priming capacity of bone marrow dendritic cells.
Data indicate that tryptophan hydroxylase (Tph)1-deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis.
Data show that Tph-1 (tryptophan hydroxylase-1) is a potent regulator of immunity.
Parallel to Tph1 mRNA and protein induction, islet serotonin content increased to a peak level that was 200-fold higher than basal. Interestingly, only a subpopulation of the beta cells was serotonin-positive in vitro and in vivo.
nonneuronal tph1 gene has a role in cardiac function with peripheral serotonin
Review. TPH1 is expressed in the pineal gland and the enterochromaffin cells. Loss of TPH1 gene expression, and thus of peripheral 5-HT (zeige DDC ELISA Kits), leads to a cardiac dysfunction phenotype.
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
, indoleacetic acid-5-hydroxylase
, tryptophan 5-hydroxylase 1
, tryptophan 5-monooxygenase 1
, tryptophan hydroxylase (tryptophan 5-monooxygenase)
, tryptophan hydroxylase (tryptophan 5-monooxygenase
, tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
, TryPtophan Hydroxylase family member (tph-1)
, tryptophan 5-hydroxylase
, tryptophan 5-monooxygenase
, secretion regulating guanine nucleotide exchange factor
, tryptophan hydroxylase 1
, tryptophan 5-hydroxylase 1-like
, tryptophan hydroxylase