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can act as a negative mediator in autophagy through stimulation of the AKT (zeige AKT1 ELISA Kits)-MTORC1 pathway and direct interaction with LC3 (zeige MAP1LC3A ELISA Kits).
PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 15LO isoforms, 15LO1 and 15LO2, and changes their substrate competence to generate hydroperoxy-phosphatidylethanolamines (PE). Inadequate reduction of hydroperoxy-PE due to insufficiency or dysfunction of a selenoperoxidase, GPX4, leads to ferroptosis.
miR (zeige MLXIP ELISA Kits)-23a as a negative regulator of RKIP expression in AML (zeige RUNX1 ELISA Kits).
Knockdown of RKIP promotes LX-2 cell proliferation.
RKIP contributes to colitis development by promoting inflammation and mediating intestinal epithelial cell apoptosis.
The study demonstrates that miR (zeige MLXIP ELISA Kits)-543 promotes the proliferation and metastasis of prostate cancer via targeting RKIP.
RKIP inhibitors locostatin reduces extracellular matrix production as well as the migration and proliferation of myometrial and leiomyoma cells.
RKIP has a role in suppressing proliferation and metastasis of breast cancer cell lines through up-regulation of miR-185 targeting HMGA2
positive p-Ser153 RKIP expression is a favorable prognostic factor and affects clinical response to radiotherapy in nasopharyngeal carcinoma
Expression of RKIP is closely correlated with the survival of pancreatic cancer patients. RKIP can inhibit pancreatic adenocarcinoma cells proliferation, activities of migration and invasion, through downregulating Raf-1 (zeige RAF1 ELISA Kits)-MEK1 (zeige MAP2K1 ELISA Kits)/2-ERK1/2 (zeige MAPK1/3 ELISA Kits) signaling pathway.
PEBP1 mRNA levels are associated with male fertility.
NMR structure of the N- and C-terminal protein fragments [PEBP]
data suggest that phosphatidylethanolamine-binding protein (PEBP) and hippocampal cholinergic neurostimulating peptide (HCNP), the N-terminal fragment of the secreted PEBP, might be considered as new endocrine factors involved in cardiac physiology [PEBP]
The investigation of PEBP binding properties towards morphine and morphine analogs, is reported.
findings report that RKIP preferentially regulates the TLR3 (zeige TLR3 ELISA Kits)-mediated immune response in macrophages; phosphorylation of RKIP serine 109 is required for RKIP to promote TLR3 (zeige TLR3 ELISA Kits)-mediated signaling and inflammation
The authors report that Raf kinase inhibitory protein (RKIP) is essential for TBK1 (zeige TBK1 ELISA Kits) activation and type I interferon (zeige IFNA ELISA Kits) production triggered by viral infection.
RKIP knockdown promotes ERK1 (zeige MAPK3 ELISA Kits) and PPAR gamma (zeige PPARG ELISA Kits) activation during adipogenesis.
this study shows that didymin ameliorates hepatic injury through up-regulating RKIP expression
overexpression of RKIP attenuated microglia inflammation through inhibiting the NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathway in erythrocyte lysis-treated BV2 (zeige DNAH9 ELISA Kits) cells.
Overexpression of RKIP inhibits retinal ganglion cells apoptosis and promotes axonal regeneration after optic nerve crush.
RKIP overexpression increases cardiac contractility mediated by the beta1-adrenoceptor. RKIP deficiency exaggerates pressure overload-induced cardiac failure. RKIP is upregulated in heart failure.
In syngeneic mammary tumors, RKIP regulates tumor-associated macrophage recruitment by blocking HMGA2, resulting in reduced expression of numerous macrophage chemotactic factors, including CCL5 (zeige CCL5 ELISA Kits)..
These findings suggest that in addition to its known metastasis suppressor activity, RKIP may promote tumor progression through enhancing tumor initiation.
CG18594 was not expressed in embryos whatever the developmental stage, was detected in all larval tissues tested, and was only found in ovaries and gut (zeige GUSB ELISA Kits) of adult Drosophila.
Rkip prevents cilia formation and is associated with Cep290 (zeige CEP290 ELISA Kits)-mediated photoreceptor degeneration.
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
Raf kinase inhibitory protein
, hippocampal cholinergic neurostimulating peptide
, neuropolypeptide h3
, phosphatidylethanolamine-binding protein 1
, prostatic binding protein
, prostatic-binding protein
, raf kinase inhibitor protein
, phosphatidylethanolamine binding protein 1
, basic cytosolic 21 kDa protein
, Raf-1 inhibitor protein
, Raf-1 kinase inhibitor protein
, 23 kDa morphine-binding protein
, Raf kinase inhibitor protein
, phosphatidylethanolamine-binding protein
, Phosphatidylethanolamine-binding protein 1