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data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (zeige MC4R Proteine)), pro-opiomelanocortin (POMC (zeige POMC Proteine)), apolipoprotein E (APOE (zeige APOE Proteine)) and agouti-related protein (AGRP) with obesity in the North Indian population.
CSF (zeige CSF2 Proteine) AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects.
human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor (zeige MC4R Proteine)
Variations in genes AGRP, CPE (zeige CPE Proteine), GHRL (zeige GHRL Proteine), GLP1R (zeige GLP1R Proteine), HTR2A, NPY1R (zeige NPY1R Proteine), NPY5R (zeige NPY5R Proteine), SOCS3 (zeige SOCS3 Proteine) and STAT3 (zeige STAT3 Proteine) showed modest associations with BMI in European Americans.
Elevations in AgRP also favor the diagnosis of ectopic ACTH (zeige POMC Proteine) syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker.
AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients.
Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men.
Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin (zeige LEP Proteine) concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance.
AgRP and NPY (zeige NPY Proteine) are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH (zeige POMC Proteine) immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms.
P2Y6 (zeige P2RY6 Proteine) signaling in AgRP neurons is involved in the onset of obesity-associated hyperphagia.
These results identify SK3 (zeige KCNN3 Proteine) as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY (zeige NPY Proteine) neural activities and animals' feeding behavior and energy metabolism.
It was concluded that a small population of neuroendocrine cells in the adrenal medulla, and the arcuate nucleus of the hypothalamus, express AgRP and neuropeptide Y (zeige NPY Proteine) and are functionally involved in the systemic response to fasting.
These findings indicate that the relevance of AgRP to POMC (zeige POMC Proteine) neuron GABA connectivity depends on the state of AgRP neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
CRFR1 (zeige CRHR1 Proteine), in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY (zeige NPY Proteine) neurons in mice.
Data show that agouti-related protein (AgRP)-glucocorticoid receptor (zeige NR3C1 Proteine) knockout (GR-/-) mice are resistant to diet-induced obesity.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp) and neuropeptide Y (Npy (zeige NPY Proteine)) gene expression similarly in Ghrelin (zeige GHRL Proteine)+/+, Ghrelin (zeige GHRL Proteine)-/-, ghrelin receptor Ghsr (zeige GHSR Proteine)+/+, and Ghsr (zeige GHSR Proteine)-/- mice.
Suppression of sympathetic tone in AgRP-Sirt1 (zeige SIRT1 Proteine)/(--) mice reversed osteopenia in transgenic animals.
Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 (zeige DMBX1 Proteine) (deleted in malignant brain tumors 1 (zeige DMBT1 Proteine)) and AgRP is important in appetite regulation.
(Nle4, d-Phe7)-alphaMSH (zeige POMC Proteine) (NDP (zeige NDP Proteine)-alphaMSH (zeige POMC Proteine)) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor (zeige MC4R Proteine)
Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP (zeige NDP Proteine)-alphaMSH (zeige POMC Proteine)-induced cortisol production through its antagonistic properties towards MSH (zeige POMC Proteine) at the level of MC4-R (zeige MC4R Proteine)
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
, orexigenic neuropeptide
, agouti related protein
, agouti related protein homolog (mouse)