AGRP Proteine (AGRP)

Agouti Related Protein Homolog (Mouse) Proteine (AGRP)
Auf finden Sie aktuell 33 Agouti Related Protein Homolog (Mouse) (AGRP) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen AGRP Antikörper (97) und AGRP Kits (64) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 220 AGRP Produkte verfügbar.
alle Proteine anzeigen Gen GeneID UniProt
AGRP 11604 P56473
AGRP 181 O00253
AGRP 25582  

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Am meisten referenzierte AGRP Proteine

  1. Mouse (Murine) AGRP Protein expressed in Human Cells - ABIN2007600 : Ollmann, Wilson, Yang, Kerns, Chen, Gantz, Barsh: Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. in Science (New York, N.Y.) 1997 (PubMed)
    Zeige alle 5 Referenzen für 2007600

  2. Rhesus Monkey AGRP Protein expressed in Human Cells - ABIN2009970 : Yang, Chen, Lai, Gantz, Yagmurlu, Georgeson, Harmon: Molecular determination of agouti-related protein binding to human melanocortin-4 receptor. in Molecular pharmacology 2003 (PubMed)
    Zeige alle 5 Referenzen für 2009970

  3. Human AGRP Protein expressed in Human Cells - ABIN2002011 : Breit, Wolff, Kalwa, Jarry, Büch, Gudermann: The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors. in The Journal of biological chemistry 2006 (PubMed)
    Zeige alle 5 Referenzen für 2002011

  4. Human AGRP Protein expressed in Escherichia coli (E. coli) - ABIN1046484 : Shutter, Graham, Kinsey, Scully, Lüthy, Stark: Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. in Genes & development 1997 (PubMed)
    Zeige alle 3 Referenzen für 1046484

Weitere Proteine zu AGRP Interaktionspartnern

Mouse (Murine) Agouti Related Protein Homolog (Mouse) (AGRP) Interaktionspartner

  1. It was concluded that a small population of neuroendocrine cells in the adrenal medulla, and the arcuate nucleus of the hypothalamus, express AgRP and neuropeptide Y (zeige NPY Proteine) and are functionally involved in the systemic response to fasting.

  2. These findings indicate that the relevance of AgRP to POMC (zeige POMC Proteine) neuron GABA connectivity depends on the state of AgRP neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.

  3. CRFR1 (zeige CRHR1 Proteine), in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.

  4. Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY (zeige NPY Proteine) neurons in mice.

  5. Data show that agouti-related protein (AgRP)-glucocorticoid receptor (zeige NR3C1 Proteine) knockout (GR-/-) mice are resistant to diet-induced obesity.

  6. Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp) and neuropeptide Y (Npy (zeige NPY Proteine)) gene expression similarly in Ghrelin (zeige GHRL Proteine)+/+, Ghrelin (zeige GHRL Proteine)-/-, ghrelin receptor Ghsr (zeige GHSR Proteine)+/+, and Ghsr (zeige GHSR Proteine)-/- mice.

  7. Suppression of sympathetic tone in AgRP-Sirt1 (zeige SIRT1 Proteine)/(--) mice reversed osteopenia in transgenic animals.

  8. Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 (zeige DMBX1 Proteine) (deleted in malignant brain tumors 1 (zeige DMBT1 Proteine)) and AgRP is important in appetite regulation.

  9. mTORC1 in Agrp neurons controls circadian expression of orexigenic neuropeptides but is dispensable for the regulation of feeding behavior and energy metabolism

  10. Absence of Mc3rs (but not Ghsrs) was associated with lower AgRP/Npy (zeige NPY Proteine) expression, suggesting attenuated responses to signals of negative energy balance.

Human Agouti Related Protein Homolog (Mouse) (AGRP) Interaktionspartner

  1. data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction.

  2. The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (zeige MC4R Proteine)), pro-opiomelanocortin (POMC (zeige POMC Proteine)), apolipoprotein E (APOE (zeige APOE Proteine)) and agouti-related protein (AGRP) with obesity in the North Indian population.

  3. CSF (zeige CSF2 Proteine) AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects.

  4. human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor (zeige MC4R Proteine)

  5. Variations in genes AGRP, CPE (zeige CPE Proteine), GHRL (zeige GHRL Proteine), GLP1R (zeige GLP1R Proteine), HTR2A, NPY1R (zeige NPY1R Proteine), NPY5R (zeige NPY5R Proteine), SOCS3 (zeige SOCS3 Proteine) and STAT3 (zeige STAT3 Proteine) showed modest associations with BMI in European Americans.

  6. Elevations in AgRP also favor the diagnosis of ectopic ACTH (zeige POMC Proteine) syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker.

  7. AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients.

  8. Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men.

  9. Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin (zeige LEP Proteine) concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance.

  10. AgRP and NPY (zeige NPY Proteine) are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH (zeige POMC Proteine) immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms.

Cow (Bovine) Agouti Related Protein Homolog (Mouse) (AGRP) Interaktionspartner

  1. (Nle4, d-Phe7)-alphaMSH (zeige POMC Proteine) (NDP (zeige NDP Proteine)-alphaMSH (zeige POMC Proteine)) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor (zeige MC4R Proteine)

  2. Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP (zeige NDP Proteine)-alphaMSH (zeige POMC Proteine)-induced cortisol production through its antagonistic properties towards MSH (zeige POMC Proteine) at the level of MC4-R (zeige MC4R Proteine)

AGRP Protein Überblick

Protein Überblick

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.

Alternative names and synonyms associated with AGRP

  • agouti related protein (Agrp)
  • agouti related protein homolog (mouse) (AGRP)
  • agouti related protein homolog (mouse) (Agrp)
  • agouti related protein homolog (mouse)-like (AGRP)
  • agouti related protein-like (LOC100350397)
  • AGRT Protein
  • ART Protein
  • ASIP2 Protein

Bezeichner auf Proteinebene für AGRP

agouti-related protein , orexigenic neuropeptide , agouti related protein homolog (mouse) , agouti related protein

11604 Mus musculus
181 Homo sapiens
611198 Canis lupus familiaris
397275 Sus scrofa
443269 Ovis aries
25582 Rattus norvegicus
101804660 Anas platyrhynchos
100732852 Cavia porcellus
280987 Bos taurus
427535 Gallus gallus
782203 Bos taurus
100350397 Oryctolagus cuniculus
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