TRIB3 Proteine (TRIB3)

Tribbles Homolog 3 (Drosophila) Proteine (TRIB3)
Auf finden Sie aktuell 8 Tribbles Homolog 3 (Drosophila) (TRIB3) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TRIB3 Antikörper (138) und TRIB3 Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 169 TRIB3 Produkte verfügbar.
C20orf97, Ifld2, Nipk, SINK, SKIP3, TRB-3, Trb3, TRIB3, zgc:76966
alle Proteine anzeigen Gen GeneID UniProt
TRIB3 57761 Q96RU7
TRIB3 228775 Q8K4K2
TRIB3 246273 Q9WTQ6

Weitere Synonyme anzeigen

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Am meisten referenzierte TRIB3 Proteine

  1. Human TRIB3 Protein expressed in Baculovirus infected Insect Cells - ABIN2003320 : Greenman, Stephens, Smith, Dalgliesh, Hunter, Bignell, Davies, Teague, Butler, Stevens, Edkins, OMeara, Vastrik, Schmidt, Avis, Barthorpe, Bhamra, Buck, Choudhury, Clements, Cole, Dicks, Forbes, Gray et al.: Patterns of somatic mutation in human cancer genomes. ... in Nature 2007 (PubMed)
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Weitere Proteine zu TRIB3 Interaktionspartnern

Zebrafish Tribbles Homolog 3 (Drosophila) (TRIB3) Interaktionspartner

  1. study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development

Human Tribbles Homolog 3 (Drosophila) (TRIB3) Interaktionspartner

  1. High TRB3 expression is associated with basal-like breast cancer.

  2. TRIB3 promotes acute promyelocytic leukemia (zeige PML Proteine) progression through stabilization of the oncoprotein PML (zeige PML Proteine)-RARalpha (zeige RARA Proteine) and inhibition of p53 (zeige TP53 Proteine)-mediated senescence.

  3. Downregulation of TRIB3 is associated with lung cancer.

  4. This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E (zeige SEMA3E Proteine) and what effect semaphorin 3E (zeige SEMA3E Proteine) exerts on carotid atherosclerosis.

  5. overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC.

  6. Our findings suggest that good glucose and blood pressure control exhibited greater benefits on vascular outcomes in patients with TRIB3 (rs2295490) G allele.

  7. In this exploratory analysis, IRS1 (zeige IRS1 Proteine), ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (zeige INS Proteine) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.

  8. TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target

  9. TRB3 is upregulated in macrophages upon treatment with ox-LDL. TRB3 promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated.

  10. Studies suggest that pseudo-kinase family of tribbles (zeige TRIB1 Proteine) (TRIB) proteins TRIB1 (zeige TRIB1 Proteine), TRIB2 (zeige TRIB2 Proteine) and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.

Mouse (Murine) Tribbles Homolog 3 (Drosophila) (TRIB3) Interaktionspartner

  1. Chac1 (zeige CHAC1 Proteine) expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 (zeige CHAC1 Proteine) during arsenite stress.

  2. Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.

  3. In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume.

  4. Palmitate increased TRB3 expression, activated IRE1alpha (zeige ERN1 Proteine) signaling, and reduced the insulin (zeige INS Proteine)-dependent Akt (zeige AKT1 Proteine) phosphorylation. Knocking down TRB3 or IRE1alpha (zeige ERN1 Proteine) did not prevent the inhibitory effect of palmitate on Akt (zeige AKT1 Proteine) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.

  5. These data demonstrate that TRB3 inhibits insulin (zeige INS Proteine) signaling in BAT (zeige BAAT Proteine), resulting in impaired differentiation and function.

  6. TRB3 is a novel profibrotic mediator in SSc (zeige CYP11A1 Proteine). TGF-beta (zeige TGFB1 Proteine) induces TRB3, which in turn activates canonical TGF-beta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling and stimulates the release of collagen, creating a positive feedback loop that may contribute to aberrant TGF-beta (zeige TGFB1 Proteine) signalling in SSc (zeige CYP11A1 Proteine).

  7. study presents the finding that activation of the NF-kappaB (zeige NFKB1 Proteine) pathway by Porphyromonas endodontalis LPS (zeige TLR4 Proteine) is important for Wnt5a (zeige WNT5A Proteine) expression in osteoblasts, and that TRIB3 may modulate the sustained expression of Wnt5a (zeige WNT5A Proteine) in osteoblasts stimulated by P. endodontalis

  8. TRIB1 (zeige TRIB1 Proteine) and TRIB3 are more strongly expressed than TRIB2 (zeige TRIB2 Proteine) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.

  9. Trib3 interferes with the Parkinson's disease-associated prosurvival protein Parkin (zeige PARK2 Proteine) to mediate death

  10. These observations support the notion that loss of TRIB3 is associated with a more aggressive phenotype in various types of tumors by enhancing the activity of the mTORC2 (zeige CRTC2 Proteine)/AKT (zeige AKT1 Proteine)/FOXO (zeige FOXO3 Proteine) axis.

Pig (Porcine) Tribbles Homolog 3 (Drosophila) (TRIB3) Interaktionspartner

  1. This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.

TRIB3 Protein Überblick

Protein Überblick

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.

Alternative names and synonyms associated with TRIB3

  • tribbles homolog 3 (Drosophila) (trib3)
  • tribbles homolog 3 (Drosophila) (TRIB3)
  • tribbles 3 (TRIB3)
  • tribbles homolog 3 (Drosophila) (Trib3)
  • C20orf97 Protein
  • Ifld2 Protein
  • Nipk Protein
  • SINK Protein
  • SKIP3 Protein
  • TRB-3 Protein
  • Trb3 Protein
  • TRIB3 Protein
  • zgc:76966 Protein

Bezeichner auf Proteinebene für TRIB3

tribbles homolog 3 , tribbles homolog 3 (Drosophila) , tribbles homolog 3-like , TRB-3 , neuronal cell death inducible putative kinase , neuronal cell death-inducible putative kinase , p65-interacting inhibitor of NF-kappa-B , p65-interacting inhibitor of NF-kappaB , induced in fatty liver dystrophy 2 , Neuronal cell death Inducible Putative Kinase , kinase , tribbles 3

405805 Danio rerio
714636 Macaca mulatta
100439080 Pongo abelii
100603917 Nomascus leucogenys
745623 Pan troglodytes
57761 Homo sapiens
485819 Canis lupus familiaris
228775 Mus musculus
246273 Rattus norvegicus
538465 Bos taurus
100518810 Sus scrofa
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