Eukaryotic Translation Initiation Factor 2C, 1 Proteine (EIF2C1)

Bezeichnung:
Eukaryotic Translation Initiation Factor 2C, 1 Proteine (EIF2C1)
Auf www.antikoerper-online.de finden Sie aktuell 6 Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Eukaryotic Translation Initiation Factor 2C, 1 Antikörper (56) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 68 Eukaryotic Translation Initiation Factor 2C, 1 Produkte verfügbar.
Synonyme:
Ago, Ago-1, ago1, ago1-1, anon-WO0257455.29, ARGONAUTE 1, CG6671, dAgo1, Dm Ago1, Dmel\\CG6671, DsimGD25729, dsim_GLEANR_9718, EIF2C, Eif2c1, GB12654, GD25729, GERP95, l(2)04845, l(2)4845, l(2)k00208, l(2)k08121, MRE20, Q99, T1N15.2, T1N15_2
alle Proteine anzeigen Gen GeneID UniProt
EIF2C1 26523 Q9UL18
Ratte EIF2C1 EIF2C1 313594  
EIF2C1 236511 Q8CJG1

Weitere Synonyme anzeigen

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Am meisten referenzierte Eukaryotic Translation Initiation Factor 2C, 1 Proteine

  1. Human EIF2C1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004127 : Koesters, Adams, Betts, Moos, Schmid, Siermann, Hassam, Weitz, Lichter, Heitz, von Knebel Doeberitz, Briner: Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. in Genomics 1999 (PubMed)
    Zeige alle 3 Referenzen für 2004127

Weitere Proteine zu Eukaryotic Translation Initiation Factor 2C, 1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Interaktionspartner

  1. Results suggest that Wisp (zeige SNX9 Proteine) interacts with Ago1 and induces miRNA adenylation and facilitates its downregulation.

  2. Results have established a novel role of Ago-1 as a regulator of the cell cycle.

  3. AGO1 protein level is reduced in the absence of miRNA biogenesis & accumulates on depletion of GW182. Ectopic transcription of miRNAs within in vivo clones & genetic interference with the ubiquitin (zeige UBA52 Proteine)-proteasome system induced accumulation of AGO1.

  4. Smaug (zeige SAMD4A Proteine) directly recruits Ago1 to nanos mRNA in a miRNA-independent manner, thereby repressing translation.

  5. analysis of regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe

  6. The study provides a molecular explanation for the previously reported heterogeneity of miRNA 3' ends and proposes a model in which Nibbler converts miRNAs into isoforms that are compatible with the preferred length of Ago1-bound small RNAs.

  7. propose Drosophila Ago-1 as a multifunctional RNAi component that interconnects at least two unrelated events, chromatin organization in the nucleus and microRNA processing in the cytoplasm, which may be extended to the other systems

  8. these results suggest that Ago1 and its miRNA biogenesis partners play a role in oocyte determination and germline cell division in Drosophila.

  9. Ago1-RISC induces silencing via two independent pathways: shortening of the poly(A) tail and pure repression of translation

  10. Mutation of AGO2 (zeige EIF2C2 Proteine) or piwi (zeige PIWIL1 Proteine) increases silencing at piRNA clusters corresponding to an increase of HP1 (zeige CBX5 Proteine) association.

Silk Worm Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Interaktionspartner

  1. Ago1,Ago2,Ago3 and Piwi are upregulated upon infection with nucleopolyhedrovirus.

Pig (Porcine) Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Interaktionspartner

  1. Data show that Ago4 (zeige EIF2C4 Proteine)- Ago1-Ago3 (zeige EIF2C3 Proteine) genes are linked together at the p12 (zeige SPRN Proteine) of the chromosome 6, while Ago2 (zeige EIF2C2 Proteine) is located at the p15 (zeige CDKN2B Proteine) of the chromosome 4.

Human Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Interaktionspartner

  1. In miRNA-mediated gene silencing, the physical interaction between human Argonaute (zeige EIF2C2 Proteine) (hAgo (zeige FBXW7 Proteine)) and GW182 (hGW182) is essential for facilitating the downstream silencing of the targeted mRNA. hGW182 can recruit up to three copies of hAgo (zeige FBXW7 Proteine) via its three GW motifs. This may explain the observed cooperativity in miRNA-mediated gene silencing.

  2. We selected five single nucleotide polymorphisms (SNPs) (rs7813, rs2740349, rs2291778, rs910924, rs595961) in two key microRNA biosynthesis genes (GEMIN4 and AGO1) and systematically evaluated the association between these SNPs, the gene-environment interaction and lung cancer risk. This is the first study showing that rs7813 and rs595961 could be meaningful as genetic markers for lung cancer risk.

  3. Low AGO1 expression is associated with melanoma.

  4. Blocking AGO1, AGO2, or TRBP expression changes expression levels and nuclear distribution of RNAi factors Dicer, TNRC6A (GW182), and TRBP.

  5. EIF2C2 (zeige EIF2C2 Proteine), Dicer (zeige DICER1 Proteine), and Drosha (zeige DROSHA Proteine) are more highly expressed in bladder carcinoma, promote the development of bladder cancer, and suggested a poor prognosis

  6. Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing

  7. Completion of the tetrad, combined with a mutation on a loop adjacent to the active site of hAgo1, results in slicer activity that is substantially enhanced by swapping in the N domain of hAgo2 (zeige EIF2C2 Proteine).

  8. Evolutionary amino acid changes to hAGO1 were readily reversible, suggesting that loading of guide RNA and pairing of seed-based miRNA and target RNA constrain its sequence drift.

  9. nuclear Ago1 directly interacts with RNA Polymerase II and is widely associated with chromosomal loci throughout the genome with preferential enrichment in promoters of transcriptionally active genes

  10. Aberrant expression of argonaute-1/-2 in human renal cell carcinoma (zeige MOK Proteine) is possibly involved with tumorigenesis and prognosis.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Interaktionspartner

  1. up-regulated in murine macrophage RAW264.7 cells transfected by Echinococcus multilocularis miR (zeige MLXIP Proteine)-71

  2. Results from the liver show that, siRNA targets 3'UTR and the coding sequence (CDs (zeige ABHD5 Proteine)) of endogenous genes in the presence Ago2 (zeige EIF2C2 Proteine) but in its absence, only 3'UTR-targeted siRNA-mediated knockdown are active with the help of Ago1 and Ago3 (zeige EIF2C3 Proteine).

  3. enhanced flu susceptibility of Ago1/3 double-knockout mice arises from an intrinsic impairment in the ability of lung cells to tolerate flu-elicited inflammation.

  4. Ago3 (zeige EIF2C3 Proteine) is able to load microRNAs efficiently in the absence of Ago1 and Ago2 (zeige EIF2C2 Proteine), despite a significant loss of global microRNA expression

  5. describes cloning rat sequence and used RNA interference to show that the GERp95 (zeige EIF2C2 Proteine) orthologue in C. elegans is important for maturation of germ-line stem cells in the gonad.

Arabidopsis thaliana Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Interaktionspartner

  1. Results suggests that ARGONAUTE1 (AGO1) interacts with chromatin at microRNAs MIR161 and MIR173 loci and causes the disassembly of the transcriptional complex, releasing short and unpolyadenylated transcripts.

  2. that AGO1 may have functions in gene regulation independent of small RNAs.

  3. AGO1 is a major, largely HSP90 (zeige HSP90 Proteine)-independent, factor in providing environmental robustness to plants.

  4. miR168 is a key miRNA because it regulates the expression of the slicer protein ARGONAUTE1 (AGO1), which catalyzes mRNA cleavage. Interestingly, plant miR168s are highly evolutionarily conserved; however, it is unclear whether MIR168 promoter elements and expression patterns are also conserved.

  5. a total of 5,123 and 1,399 AGO1-enriched small RNAs, excluding miRNAs, were identified in Arabidopsis thaliana and rice (Oryza sativa), respectively.

  6. Mungbean yellow mosaic Indian virus AC2 interacts with AGO1 and inhibits its transcript slicing activity in vitro.

  7. AGO1, AGO2 and AGO10 promoted anti-TuMV defense in a modular way in various organs, with AGO2 providing a prominent antiviral role in leaves. AGO5, AGO7 and AGO10 had minor effects in leaves.

  8. HOS1 regulates miR168a/b and AGO1 levels in Arabidopsis by maintaining proper transcription of MIR168b.

  9. Base pairing at the 15th nucleotide of a miRNA duplex is important for miRNA sorting in both Arabidopsis AGO1 and AGO2 (zeige EIF2C2 Proteine). AGO1 tolerates, or prefers, duplexes with central mismatches.

  10. In the presence of the wild-type allele of AGO1, most of the mas (zeige MAS1 Proteine) mutations cause a mild or no mutant phenotype on their own, indicating that the ago1-52 mutant may provide a sensitized background for examining the interactions of AGO1.

Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1) Protein Überblick

Protein Überblick

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.

Alternative names and synonyms associated with Eukaryotic Translation Initiation Factor 2C, 1 (EIF2C1)

  • Argonaute-1 (AGO1)
  • argonaute 1 (AGO1)
  • argonaute 1 (ago1)
  • Argonaute-1 (Ago-1)
  • Argonaute 1 (DsimAGO1)
  • argonaute 1 (Ago1)
  • eukaryotic translation initiation factor 2C, 1 (EIF2C1)
  • argonaute RISC catalytic component 1 (AGO1)
  • argonaute RISC catalytic component 1 (Ago1)
  • argonaute RISC catalytic subunit 1 (Ago1)
  • protein argonaute 1 (AGO1)
  • Ago Protein
  • Ago-1 Protein
  • ago1 Protein
  • ago1-1 Protein
  • anon-WO0257455.29 Protein
  • ARGONAUTE 1 Protein
  • CG6671 Protein
  • dAgo1 Protein
  • Dm Ago1 Protein
  • Dmel\\CG6671 Protein
  • DsimGD25729 Protein
  • dsim_GLEANR_9718 Protein
  • EIF2C Protein
  • Eif2c1 Protein
  • GB12654 Protein
  • GD25729 Protein
  • GERP95 Protein
  • l(2)04845 Protein
  • l(2)4845 Protein
  • l(2)k00208 Protein
  • l(2)k08121 Protein
  • MRE20 Protein
  • Q99 Protein
  • T1N15.2 Protein
  • T1N15_2 Protein

Bezeichner auf Proteinebene für EIF2C1

AGO1-PA , AGO1-PB , AGO1-PC , AGO1-PD , ARGONAUTE-1 , Argonaute1 , CG6671-PA , CG6671-PB , CG6671-PC , CG6671-PD , argonaute , argonaute 1 , argonaute protein 1 , mRNA-like ncRNA in embryogenesis 20 , Argonaute-1 , DsimAGO1-PA , DsimGD25729-PA , GD25729-PA , argonaute-1 , eukaryotic translation initiation factor 2C, 1 , protein argonaute-1-like , Golgi Endoplasmic Reticulum protein 95 kDa , argonaute1 , eIF-2C 1 , eIF2C 1 , hAgo1 , protein argonaute-1 , putative RNA-binding protein Q99 , Piwi/Argonaute family protein meIF2C1 , argonaute RISC catalytic component 1 , mAgo1

GENE ID SPEZIES
36544 Drosophila melanogaster
552062 Apis mellifera
593855 Strongylocentrotus purpuratus
659936 Tribolium castaneum
6734380 Drosophila simulans
100124421 Bombyx mori
100386910 Callithrix jacchus
100440631 Pongo abelii
100482671 Ailuropoda melanoleuca
100499510 Sus scrofa
456747 Pan troglodytes
26523 Homo sapiens
313594 Rattus norvegicus
236511 Mus musculus
475337 Canis lupus familiaris
841262 Arabidopsis thaliana
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