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INSIG2 plays a role in weight gain and obesity during clozapine treatment
These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR (zeige HMGCR Proteine) are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.
There may be a connection between INSIG2 expression and metastatic dissemination of colorectal cancer without any effect on tumorigenesis.
Insulin (zeige INS Proteine) resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1 (zeige PFKFB1 Proteine), PFKFB3 (zeige PFKFB3 Proteine), and HK2 (zeige HK2 Proteine) genes in the blood cells as compared to obese patients with normal insulin (zeige INS Proteine) sensitivity.
Results confirmed that genetic variation in INSIG2 is associated with both overweight and LDL in non-Hispanic white children.
This study suggests that the G allele in the INSIG2 single nucleotide polymorphism rs7566605 is more relevant for changes in intramuscular adipose tissue following training than for the amount of subcutaneous fat.
INSIG2 is involved in adipogenesis and MC4R (zeige MC4R Proteine) effects hormonal appetite control in response to the amount of adipose tissue.
The results provided evidence for identifying genetic factors of nonalcoholic fatty liver disease (NAFLD) and may be useful for risk assessment and personalized medicine of NAFLD.
The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.
identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
FASN (zeige FASN Proteine) gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition
INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c (zeige SREBF1 Proteine)-driven lipogenesis.
Data show that REV-ERBalpha (zeige NR1D1 Proteine) participates in the circadian modulation of SREBP activity, and the expression of SREBP target genes involved in cholesterol and lipid metabolism via the cyclic transcription of Insig2.
Liver-specific mRNA for Insig-2 down-regulated by insulin (zeige INS Proteine): implications for fatty acid synthesis.
a vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes
Insig2 identified as a strong candidate susceptibility gene for total plasma cholesterol levelsin inbred mice strains
Treatment of pregnant mice with the HMG-CoA reductase (zeige HMGCR Proteine) inhibitor lovastatin reduced sterol synthesis in Insig2-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.
A critical gene involved in cholesterol homeostasis, Insig-2, was induced when mice or cultured cells were treated with FXRalpha (zeige NR1H4 Proteine) agonists or infected with constitutively active FXRalpha (zeige NR1H4 Proteine).
Peroxisome deficiency causes a complex phenotype because of hepatic SREBP-1c (zeige SREBF1 Proteine),-2/Insig-2a,b dysregulation associated with endoplasmic reticulum stress
Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 and insig-2 at an early phase in adipocyte differentiation.
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
insulin-induced gene 2 protein
, insulin-induced gene 2 protein-like
, insulin induced gene 2
, INSIG2 membrane protein
, insulin induced protein 2
, insulin-induced membrane protein 2
, INSIG-2 membrane protein
, Insulin-induced gene 2 protein