INSIG2 Proteine (INSIG2)

Bezeichnung:
Insulin Induced Gene 2 Proteine (INSIG2)
Auf www.antikoerper-online.de finden Sie aktuell 4 Insulin Induced Gene 2 (INSIG2) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen INSIG2 Antikörper (24) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 30 INSIG2 Produkte verfügbar.
Synonyme:
2900053I11Rik, C730043J18Rik, Insig-2, MGC82156
alle Proteine anzeigen Gen GeneID UniProt
INSIG2 51141 Q9Y5U4
INSIG2 72999 Q91WG1
Ratte INSIG2 INSIG2 288985 Q80UA9

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Weitere Proteine zu INSIG2 Interaktionspartnern

Human Insulin Induced Gene 2 (INSIG2) Interaktionspartner

  1. INSIG2 plays a role in weight gain and obesity during clozapine treatment

  2. These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR (zeige HMGCR Proteine) are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  3. There may be a connection between INSIG2 expression and metastatic dissemination of colorectal cancer without any effect on tumorigenesis.

  4. Insulin (zeige INS Proteine) resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1 (zeige PFKFB1 Proteine), PFKFB3 (zeige PFKFB3 Proteine), and HK2 (zeige HK2 Proteine) genes in the blood cells as compared to obese patients with normal insulin (zeige INS Proteine) sensitivity.

  5. Results confirmed that genetic variation in INSIG2 is associated with both overweight and LDL in non-Hispanic white children.

  6. This study suggests that the G allele in the INSIG2 single nucleotide polymorphism rs7566605 is more relevant for changes in intramuscular adipose tissue following training than for the amount of subcutaneous fat.

  7. INSIG2 is involved in adipogenesis and MC4R (zeige MC4R Proteine) effects hormonal appetite control in response to the amount of adipose tissue.

  8. The results provided evidence for identifying genetic factors of nonalcoholic fatty liver disease (NAFLD) and may be useful for risk assessment and personalized medicine of NAFLD.

  9. The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.

  10. identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

Pig (Porcine) Insulin Induced Gene 2 (INSIG2) Interaktionspartner

  1. FASN (zeige FASN Proteine) gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition

Mouse (Murine) Insulin Induced Gene 2 (INSIG2) Interaktionspartner

  1. INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c (zeige SREBF1 Proteine)-driven lipogenesis.

  2. These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR (zeige HMGCR Proteine) are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  3. Data show that REV-ERBalpha (zeige NR1D1 Proteine) participates in the circadian modulation of SREBP activity, and the expression of SREBP target genes involved in cholesterol and lipid metabolism via the cyclic transcription of Insig2.

  4. Liver-specific mRNA for Insig-2 down-regulated by insulin (zeige INS Proteine): implications for fatty acid synthesis.

  5. a vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes

  6. Insig2 identified as a strong candidate susceptibility gene for total plasma cholesterol levelsin inbred mice strains

  7. Treatment of pregnant mice with the HMG-CoA reductase (zeige HMGCR Proteine) inhibitor lovastatin reduced sterol synthesis in Insig2-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.

  8. A critical gene involved in cholesterol homeostasis, Insig-2, was induced when mice or cultured cells were treated with FXRalpha (zeige NR1H4 Proteine) agonists or infected with constitutively active FXRalpha (zeige NR1H4 Proteine).

  9. Peroxisome deficiency causes a complex phenotype because of hepatic SREBP-1c (zeige SREBF1 Proteine),-2/Insig-2a,b dysregulation associated with endoplasmic reticulum stress

  10. Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 and insig-2 at an early phase in adipocyte differentiation.

INSIG2 Protein Überblick

Protein Überblick

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.

Alternative names and synonyms associated with INSIG2

  • insulin induced gene 2 (insig2)
  • insulin induced gene 2 (INSIG2)
  • insulin induced gene 2 (Insig2)
  • 2900053I11Rik Protein
  • C730043J18Rik Protein
  • Insig-2 Protein
  • MGC82156 Protein

Bezeichner auf Proteinebene für INSIG2

insulin-induced gene 2 protein , INSIG-2 , insulin-induced gene 2 protein-like , insulin induced gene 2 , INSIG2 membrane protein , insulin induced protein 2 , insulin-induced membrane protein 2 , INSIG-2 membrane protein , Insulin-induced gene 2 protein

GENE ID SPEZIES
399645 Danio rerio
447512 Xenopus laevis
496587 Xenopus (Silurana) tropicalis
693654 Macaca mulatta
743385 Pan troglodytes
51141 Homo sapiens
100170127 Sus scrofa
534440 Bos taurus
72999 Mus musculus
288985 Rattus norvegicus
610496 Canis lupus familiaris
424276 Gallus gallus
100173587 Pongo abelii
100137376 Papio anubis
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