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SRA1 was down expressed in HCC (zeige FAM126A Proteine) and its level was associated with tumor size and GLU (zeige DCTN1 Proteine) level in patients with HCC (zeige FAM126A Proteine) for the first time. SRA1 may be a helpful biomarker to diagnostic HCC (zeige FAM126A Proteine).
By studying a cohort of idiopathic hypogonadotropic hypogonadism, our findings strongly suggest that SRA1 gene function is required for initiation of puberty in humans
Results identified H15-H18 domains in SRA gene playing a key role in regulating ER-mediated transcription.
in human pluripotent stem cells SRA interacts with NANOG and is important for maintenance of the pluripotent state.
Data suggest that expression of SRA1 (mRNA and protein) is linked to cancer cell motility (invasiveness of breast/cervical tumor cells) and regulation of gene expression.
lncRNA SRA expression is potentially associated with PCOS and it has positive correlation with obesity in PCOS, thereby suggesting that elevated lncRNA SRA might be an important mediator in adiposity-related processes in PCOS for susceptible individuals.
In endometrioma patients, the surrounding ovarian tissue steroid receptor (zeige ESR2 Proteine) RNA activator expression is higher compared to controls.
The structure is a five-helix bundle that is distinct from known RNA-binding motifs and instead is similar to the carboxy-terminal domain of the yeast spliceosome protein PRP18 (zeige PRPF18 Proteine), which stabilizes specific protein-protein interactions.
This study provides evidence that both ER-beta1 and SRAP could be predictive biomarkers of tamoxifen benefit in ER-alpha (zeige ESR1 Proteine)-negative premenopausal early breast cancer.
The presence of SRAP and multiple SRAP-like peptides in estrogen receptor (zeige ESR1 Proteine) positive breast cancer samples correlates with clinical outcome.
Visfatin (zeige NAMPT Proteine) upregulated CD36 (zeige CD36 Proteine) and SRA (zeige MSR1 Proteine) expression and downregulated ABCA1 (zeige ABCA1 Proteine) and ABCG1 (zeige ABCG1 Proteine) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (zeige EPHB2 Proteine)-dependent pathways.
The results of this study demonstrated that SRA (zeige MSR1 Proteine) could attenuate microglia mediated inflammation injury in ICH (zeige ACE Proteine). In addition, SRA (zeige MSR1 Proteine) mediated negative feedback mechanism in neuroimmune homeostasis.
these data are the first to indicate a functional role for SRA (zeige MSR1 Proteine) in adipose tissue biology and glucose homeostasis in vivo.
Dax1 (zeige NR0B1 Proteine) augmentation of LRH-1 (zeige NR5A2 Proteine)-mediated Oct4 (zeige POU5F1 Proteine) activation is dependent upon steroid receptor (zeige ESR2 Proteine) RNA activator
DEAD-box RNA helicase (zeige DDX56 Proteine) p68 (DDX5 (zeige DDX5 Proteine)) and its associated noncoding RNA, steroid receptor (zeige ESR2 Proteine) RNA activator (SRA (zeige MSR1 Proteine)), form a complex with CTCF (zeige CTCF Proteine) that is essential for insulator function
Steroid receptor (zeige ESR2 Proteine) RNA activator stimulates proliferation as well as apoptosis in vivo
Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (zeige RARA Proteine) (mRAR)gamma when coexpressed with steroid receptor (zeige ESR2 Proteine) RNA activator.
both MARCO (zeige MARCO Proteine) and SR-A (zeige MSR1 Proteine) could be involved in the positioning and differentiation of macrophages, possibly through interaction with endogenous ligands
These findings reveal novel functions of SRA (zeige MSR1 Proteine) and Dax-1 (zeige NR0B1 Proteine) in steroidogenesis and adrenal biology.
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA.
steroid receptor RNA activator 1 (complexes with NCOA1)
, steroid receptor RNA activator protein
, steroid receptor coactivator
, steroid receptor RNA activator 1