Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human DAB2IP Antikörper:
anti-Rat (Rattus) DAB2IP Antikörper:
anti-Mouse (Murine) DAB2IP Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal DAB2IP Primary Antibody für IP, WB - ABIN440620
Cook, Kim, Terao, Gotoh, Higuchi: Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer. in Cell death & disease 2012
Study shows that up to 62% of luminal B cancers have lost expression of at least one of the DAB2IP and RASAL2 (zeige RASAL2 Antikörper) genes. However, the tumors that have lost both genes frequently present as advanced disease and are more likely to recur. Importantly, the report provide evidence that DAB2IP and RASAL2 (zeige RASAL2 Antikörper) can individually function as tumor suppressors in breast cancer.
The low expression of DAB2IP in bladder carcinoma cells was related to drug resistance.
Down-regulation of DAB2IP correlated negatively with hnRNPK (zeige HNRNPK Antikörper) and MMP2 (zeige MMP2 Antikörper) expressions in CRC (zeige CALR Antikörper) tissues. In conclusion, our study elucidates a novel mechanism of the DAB2IP/hnRNPK (zeige HNRNPK Antikörper)/MMP2 (zeige MMP2 Antikörper) axis in the regulation of CRC (zeige CALR Antikörper) invasion and metastasis, which may be a potential therapeutic target.
DAB2IP appears to be a new prognostic/predictive marker for metastatic renal cell cancer (mRCC) patients, and its function provides a new insight into the molecular mechanisms of drug resistance to mTOR (zeige FRAP1 Antikörper) inhibitors, which also can be used to develop new strategies to overcome drug-resistant mRCC.
Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2 (zeige DAB2 Antikörper)/DAB2) interactive protein (DAB2IP) expression, EGR-1 (zeige EGR1 Antikörper) gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 (zeige EGR1 Antikörper) gene expression sensitized radioresistant cells to IR accompanied by DAB2IP overexpression and STAT3 (zeige STAT3 Antikörper) inactivation. In addition, NF-kappaB (zeige NFKB1 Antikörper) inhibitor, BAY11-7082 enhanced resistant cells' radiosensitivity and chemos...
Our findings demonstrate a novel function of DAB2IP in the maintenance of KT-MT structure and SAC (zeige ADCY10 Antikörper) regulation during mitosis which is essential for chromosomal stability.
DAB2IP may be involved in forming acquired radioresistance in PC3 (zeige PCSK1 Antikörper) cells. DAB2IP-deficient cells are resistant to low and high-LET radiation using different mechanisms. DAB2IP-deficient cells are resistant to both gamma-rays and alpha-particles.
our data provided evidence to verify that miR (zeige MLXIP Antikörper)-92b was able to directly target DAB2IP, a well-known tumor suppressor, and inhibit epithelialmesenchymal transition of bladder cancer cells
DAB2IP protein levels are higher in bladder cancer than in upper tract urothelial carcinoma and in superficial bladder cancer
Infiltrating T cells regulate ERbeta (zeige ESR2 Antikörper)/DAB2IP signals in renal cell carcinoma (zeige MOK Antikörper).
DAB2IP loss reprograms intracellular signal transduction and anti-apoptotic gene expression, which potentiates prostate cancer cell survival from androgen deprivation therapy-induced cell death.
Germ cell-specific or Sertoli cell-specific deletion of Aip1 gene each led to significant defects in germ cell migration after postnatal day 4 or 5, accompanied by elevated levels of actin filaments (F-actin) in the affected cells.
Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments.
results suggest that Dab2IP plays an important role in the migration and positioning of a subpopulation of later-born (layers II-IV) neurons, likely through the regulation of Rap1 and integrin signaling.
Our data reveal that AIP1 (zeige PDCD6IP Antikörper), by inhibiting VEGFR2 (zeige KDR Antikörper)-dependent signaling in tumor niche, suppresses tumor EMT (zeige ITK Antikörper) switch, tumor angiogenesis, and tumor premetastatic niche formation to limit tumor growth and metastasis.
AIP1 (zeige PDCD6IP Antikörper) was elevated in the brain of AD Tg2576 mice. Abeta1-42 treatment induced the interaction of AIP1 (zeige PDCD6IP Antikörper) and ASK1 (zeige MAP3K5 Antikörper), which led to dissociation of ASK1 (zeige MAP3K5 Antikörper) and 14-3-3 (zeige YWHAQ Antikörper).
site-specific methylation of mDab2ip gene during cerebellar development may play a role in inclusion of exon 5, resulting in a Dab2ip transcript variant that encodes a full pleckstrin (zeige PLEK Antikörper) homology (PH) domain.
Study showed that DAB2IP can be functionally inactivated by physical interaction with mutant p53 (zeige TP53 Antikörper) proteins with implications for the response of cancer cells to inflammatory cytokines.
DAB2IP is a unique intrinsic androgen receptor (zeige AR Antikörper) modulator in normal cells, and likely can be further developed into a therapeutic agent for rpostate cancer.
AIP1 (zeige PDCD6IP Antikörper) knockouts have reduced retinal angiogenesis. Vascular endothelial cell (but not neuronal)-specific deletion of AIP1 (zeige PDCD6IP Antikörper) causes similar defects. AIP1 (zeige PDCD6IP Antikörper) via miR (zeige MLXIP Antikörper)-1236 increases VEGFR-3 (zeige FLT4 Antikörper) expression and binds it, enhancing endocytosis and stability.
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005
DAB2 interacting protein
, ASK-interacting protein 1
, ASK1-interacting protein 1
, DAB2 interaction protein
, DAB2-interacting protein
, DOC-2/DAB-2 interactive protein
, DOC-2/DAB2 interactive protein
, disabled homolog 2-interacting protein
, nGAP-like protein
, apoptosis signal-regulating kinase 1-interacting protein 1
, disabled homolog 2 interacting protein
, DOC2/DAB2 interactive protein
, disabled 2 interacting protein long form