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Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2 (zeige CA2 Proteine)+) signaling, was the major host cell PilA binding protein.
A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.
Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB (zeige WRB Proteine) as components of the TRC40 (zeige ASNA1 Proteine) receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
CAML was found to play a crucial role in the PRL (zeige PRL Proteine)/PRLR (zeige PRLR Proteine)-dependent growth of breast cancer cells.
this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production.
Data show that tetherin (zeige BST2 Proteine) restricts particle release and does not require CAML for this effect.
CAMLG was more frequently significantly overexpressed in acute myeloid leukemia (zeige BCL11A Proteine) patients with CD56 (zeige NCAM1 Proteine) immunophenoytpe
Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets cellular CAML to increase the cytosolic Ca(2 (zeige CA2 Proteine)+) response, which consequently protects cells from mitochondrial damage and apoptosis
CAML is an important signal transducer for the actions of Ang II (zeige AGT Proteine) in regulating the calcineurin-NFAT (zeige NFATC1 Proteine) pathway and the interaction of CAML with ATRAP (zeige AGTRAP Proteine) may mediate the Ang II (zeige AGT Proteine) actions in vascular physiology
The intracellular C-terminus of fibrocystin interacts with CAML, a protein with an intracellular distribution that is similar to that of PKD2 (zeige PKD2 Proteine).
this study identified a novel role for B cell-specific, BAFF (zeige TNFSF13B Proteine)-dependent transmembrane activator and CAML interactor (zeige TNFRSF13B Proteine) signals in atherosclerosis pathogenesis
Deletion of calcium-modulating cyclophilin ligand causes deafness in mouse model.
Conditional deletion of CAML in CD19 (zeige CD19 Proteine)-Cre transgenic mice reduced follicular B cell numbers & increased rates of homeostatic proliferation. They had increased cellular turnover & normal proliferative ability.
Loss of CAMLG protein failed to undergo normal T-cell development and exhibited dramatically increased rates of apoptosis.
results implicate Tmub1 (zeige TMUB1 Proteine) in the regulation of locomotor activity and wakefulness and suggest that Tmub1 (zeige TMUB1 Proteine) binds to and functions together with CAMLG
These data implicate calcium-modulating cyclophilin ligand in epidermal growth factor (EGF (zeige EGF Proteine)) receptor (zeige EGFR Proteine) signaling and suggest that it may play a role in receptor recycling during long-term proliferative responses to EGF (zeige EGF Proteine).
CAML as an essential mediator of T cell survival during thymopoiesis and its loss deregulates lymphocyte specific protein tyrosine kinase (zeige LCK Proteine) p56 (zeige IFIT1 Proteine)(p56Lck (zeige LCK Proteine)) signaling.
specific role of CAML in functional expression and endocytic recycling of postsynaptic GABA(A) receptors
our data identify CAML as a novel chromosomal instability gene and suggest that CAML protein acts as a key regulator of mitotic spindle function and a modulator of SAC (zeige ADCY10 Proteine) maintenance.
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
calcium modulating ligand
, calcium signal-modulating cyclophilin ligand
, calcium modulating cyclophilin ligand CAML
, calcium-modulating cyclophilin ligand
, calcium-signal modulating cyclophilin ligand
, cyclophilin B-binding protein