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SLC6A3 Proteine (SLC6A3)

Bezeichnung:
Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 Proteine (SLC6A3)
Auf www.antikoerper-online.de finden Sie aktuell 7 Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SLC6A3 Antikörper (106) und SLC6A3 Kits (45) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 165 SLC6A3 Produkte verfügbar.
Synonyme:
DAT, DAT1, PKDYS, SLC6A3
alle Proteine anzeigen Gen GeneID UniProt
SLC6A3 13162 Q61327
SLC6A3 6531 Q01959
SLC6A3 24898 P23977

Weitere Synonyme anzeigen

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Weitere Proteine zu SLC6A3 Interaktionspartnern

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) Interaktionspartner

  1. DNA of the impulsive but not the calm subjects was methylated at one DAT SNP.

  2. nitrative damage accumulates in midbrain neurons with age; The capacity of a dopamine neuron to accumulate more cytosolic DA, as inferred from DA transporter expression, is related to accumulation of nitrative damage

Caenorhabditis elegans (C. elegans) Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) Interaktionspartner

  1. Endogenous dopamine actions in C. elegans are tightly regulated by synaptic DAT-1.

  2. loss of UNC-64/DAT-1 interactions leads to enhanced synaptic dopamine release

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) Interaktionspartner

  1. Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3.

  2. This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation.

  3. The sigma-1R deficiency through suppressing NR2B (zeige GRIN2B Proteine) function and DAT expression can reduce MPTP (zeige PTPN2 Proteine)-induced death of dopaminergic neurons and parkinsonism.

  4. DAT gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 (zeige CA1 Proteine) field of the hippocampus.

  5. Results show that moderate increases in DAT function cause spontaneous dopaminergic cell loss, oxidative stress and fine motor impairment that is reversed by l-DOPA treatment

  6. Chronic and acute reductions of DAT functioning in mice impaired decision-making.

  7. These results demonstrate that the presence of the N-terminal tag leads to impaired DAT protein expression in vivo due in part to improper trafficking of the tagged transporter.

  8. studies demonstrate an in vivo functional impact of the DAT Val559 variant, providing support for the ability of DAT dysfunction to impact risk for mental illness.

  9. The data of this study imply that individual differences in DAT expression (either genetically or pharmacologically induced) may affect susceptibility to addiction of different types of psychostimulants.

  10. findings support the idea that altered DAT and VMAT2 (zeige Slc18a2 Proteine) expression affect age-related changes in dopaminergic function.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) Interaktionspartner

  1. DAT-mediated dopamine uptake plays a role in the absorption and distribution of dopamine following intranasal administration

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3 (SLC6A3) Interaktionspartner

  1. the dopamine transporter SLC6A3 constitutes a novel biomarker that is highly specific for clear cell renal cell carcinoma

  2. Data suggest that variants rs28363170 and rs3836790 in the solute carrier family 6 member 3 gene are not associated with sporadic Parkinson's disease in Han Chinese population.

  3. Study systematically designed and characterized a set of 24 substrate-based bivalent ligands, and in combination with mutagenesis, induced-fit docking calculations, electrophysiology, and cysteine accessibility measurements; revealed novel insight into the molecular basis of substrate recognition in hSERT (zeige SLC6A4 Proteine) and hDAT

  4. these findings provide compelling experimental evidence that DAT N and C termini synergistically contribute to substrate and inhibitor affinities.

  5. these results are the first demonstration of pharmacological chaperoning of DAT and suggest this may be a viable approach to increase DAT levels in Dopamine Transporter Deficiency Syndrome and other conditions associated with reduced DAT function.

  6. total of 1799 differentially methylated regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant methylation differences were confirmed in breast cancer patients through quantitative real-time polymerase chain reaction.Methylation of those aforementioned genes in white blood cells of our young patients may highlight their potential as early epimarkers

  7. Data indicate genetic association between dopamine transporter SLC6A3 (DAT1) and hypertension, and the specific variable number tandem repeats (VNTR) alleles of SLC6A3 may be a risk factor for hypertension.

  8. The effects of parenting on self-control and offending are most pronounced for those who carry plasticity alleles for both MAOA (zeige MAOA Proteine) and DAT1. Thus, MAOA (zeige MAOA Proteine) and DAT1 may be implicated in offending because they increase the negative effects of parenting on self-control. Implications for theory are discussed.

  9. The presence of particular variants of variable number tandem repeat polymorphisms in 3' untranslated region of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.

  10. Increased nigral SLC6A3 activity may be a risk factor for SCZ.

SLC6A3 Protein Überblick

Protein Überblick

This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.

Alternative names and synonyms associated with SLC6A3

  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (SLC6A3)
  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (slc6a3)
  • Protein DAT-1 (dat-1)
  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (Slc6a3)
  • solute carrier family 6 (neurotransmitter transporter), member 3 (SLC6A3)
  • solute carrier family 6 (neurotransmitter transporter), member 3 (Slc6a3)
  • DAT Protein
  • DAT1 Protein
  • PKDYS Protein
  • SLC6A3 Protein

Bezeichner auf Proteinebene für SLC6A3

dopamine transporter variant II , sodium-dependent dopamine transporter , solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 , sodium-dependent dopamine transporter-like , DA transporter , dopamine transporter 1 , solute carrier family 6 member 3 , DAT , solute carrier family 6, member 3

GENE ID SPEZIES
574143 Macaca mulatta
609304 Canis lupus familiaris
750842 Pan troglodytes
100054747 Equus caballus
100393968 Callithrix jacchus
100478402 Ailuropoda melanoleuca
100488824 Xenopus (Silurana) tropicalis
176304 Caenorhabditis elegans
13162 Mus musculus
788410 Bos taurus
6531 Homo sapiens
24898 Rattus norvegicus
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