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XRCC1 and PNKP (zeige PNKP Proteine) interact via a high-affinity phosphorylation-dependent interaction site in XRCC1 and a forkhead-associated domain in PNKP (zeige PNKP Proteine). Data suggest a second PNKP (zeige PNKP Proteine) interaction site in XRCC1 that binds PNKP (zeige PNKP Proteine) with lower affinity and independently of XRCC1 phosphorylation. (XRCC1 = X-ray repair cross complementing protein 1; PNKP (zeige PNKP Proteine) = polynucleotide kinase 3'-phosphatase (zeige PNKP Proteine))
APEH (zeige APEH Proteine) interacts with the amino-terminal domain of XRCC1. Localization of APEH (zeige APEH Proteine) at sites of nuclear damage is mediated by direct interaction with XRCC1.
XRCC1 Arg194 allele is a predicting factor for renal cell carcinoma (zeige MOK Proteine).
this updated and cumulative meta-analysis indicated that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma
Results show that some polymorphic variants in XRCC1 and OGG1 (zeige OGG1 Proteine) are associated with increased DNA damage in Alzheimer's Disease.
The interaction of OGG1 (zeige OGG1 Proteine) and XRCC1 DNA repair polymorphisms and arsenic exposure enhances telomeric DNA damage.
either PARP1 (zeige PARP1 Proteine) or PARP2 (zeige PARP2 Proteine) are sufficient for near-normal XRCC1 recruitment at oxidative single-strand breaks
contribution of microhomology-mediated end joining (MMEJ) to DNA double-strand break repair in the genome is affected by radiation exposure via enhancement of the formation of MMEJ-proficient XRCC1 complex
Trp (zeige TBPL1 Proteine) allele of codon 194 XRCC1 is a potential risk factor for breast cancer in Kurdish ethnicity. Furthermore, effect of this polymorphism on clinical and histological features of breast cancer was significant
This study suggests that the genetic variant of XRCC1 rs25487 may contribute to the etiology of ischemic stroke.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (zeige PARP1 Proteine) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (zeige ALDH1A2 Proteine)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (zeige OGG1 Proteine), Neil1 (zeige NEIL1 Proteine), Mutyh (zeige MUTYH Proteine) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (zeige AFG3L2 Proteine) serves to recruit XRCC1 that in turn binds and recruits pol beta (zeige POLB Proteine), the primary DNA polymerase (zeige POLB Proteine) of the base excision repair pathway.
Lig4 (zeige LIG4 Proteine) and XRCC1 double-deficient cells switch as efficiently as Lig4 (zeige LIG4 Proteine)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (zeige LIG1 Proteine)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
data reveal that the critical biological role of Lig3 (zeige LIG3 Proteine) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair
results establish a role for Lig3 (zeige LIG3 Proteine) in mitochondria, but distinguish it from its interacting protein Xrcc1
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein