XRCC1 Proteine (XRCC1)

Bezeichnung:
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 Proteine (XRCC1)
Auf www.antikoerper-online.de finden Sie aktuell 6 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen XRCC1 Antikörper (126) und XRCC1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 142 XRCC1 Produkte verfügbar.
Synonyme:
MGC80909, RCC, Xrcc-1, XRCC1
alle Proteine anzeigen Gen GeneID UniProt
XRCC1 7515 P18887
Maus XRCC1 XRCC1 22594 Q60596
XRCC1 84495 Q9ESZ0

Weitere Synonyme anzeigen

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Weitere Proteine zu XRCC1 Interaktionspartnern

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

  1. The interaction of OGG1 (zeige OGG1 Proteine) and XRCC1 DNA repair polymorphisms and arsenic exposure enhances telomeric DNA damage.

  2. either PARP1 (zeige PARP1 Proteine) or PARP2 (zeige PARP2 Proteine) are sufficient for near-normal XRCC1 recruitment at oxidative single-strand breaks

  3. contribution of microhomology-mediated end joining (MMEJ) to DNA double-strand break repair in the genome is affected by radiation exposure via enhancement of the formation of MMEJ-proficient XRCC1 complex

  4. Trp (zeige TBPL1 Proteine) allele of codon 194 XRCC1 is a potential risk factor for breast cancer in Kurdish ethnicity. Furthermore, effect of this polymorphism on clinical and histological features of breast cancer was significant

  5. This study suggests that the genetic variant of XRCC1 rs25487 may contribute to the etiology of ischemic stroke.

  6. Individuals carrying theGSTP1 Ile-Ile or XRCC1399 Arg-Arg genotypes showed greater DNA damage than observed for other alleles.

  7. The current meta-analysis demonstrates that the XRCC1 Arg399Gln polymorphism confers susceptibility to autoimmune diseases in Asians and Caucasians and, in particular, shows that XRCC1 Arg399Gln polymorphism is associated with rheumatoid arthritis.

  8. Specific BER proteins required for processing a DNA substrate with a uracil adjacent to a cisplatin ICL. The lack of XRCC1 leads to increased DNA damage and results in increased cisplatin cytotoxicity.

  9. Knockdown of endogenous Mcl-1 (zeige MCL1 Proteine) by RNA interference significantly accelerated the repair of DNA lesions in glycochenodeoxycholate-treated cells. However, unlike XRCC1, poly(ADP-ribose) polymerase (zeige PARP1 Proteine) was induced following Mcl-1 (zeige MCL1 Proteine) knockdown. Conversely, poly(ADP-ribose) polymerase (zeige PARP1 Proteine) suppression was observed following glycochenodeoxycholate treatment of cells overexpressing Mcl-1 (zeige MCL1 Proteine)

  10. the association of six non-synonymous coding variants from XRCC1, XRCC3 (zeige XRCC3 Proteine) and XPD (zeige ERCC2 Proteine) genes with hepatocellular carcinoma risk, was assessed.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) Interaktionspartner

  1. data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (zeige PARP1 Proteine) as a therapeutic target in DNA strand break repair-defective disease

  2. We have characterized the nuclear localization signal (NLS (zeige ALDH1A2 Proteine)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.

  3. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (zeige OGG1 Proteine), Neil1 (zeige NEIL1 Proteine), Mutyh (zeige MUTYH Proteine) and Xrcc1 in the brain of adult offspring.

  4. In cells with DNA base damage, PAR (zeige AFG3L2 Proteine) serves to recruit XRCC1 that in turn binds and recruits pol beta (zeige POLB Proteine), the primary DNA polymerase (zeige POLB Proteine) of the base excision repair pathway.

  5. Lig4 (zeige LIG4 Proteine) and XRCC1 double-deficient cells switch as efficiently as Lig4 (zeige LIG4 Proteine)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination

  6. findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (zeige LIG1 Proteine)) may contribute more to A-EJ than previously considered

  7. Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.

  8. Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.

  9. data reveal that the critical biological role of Lig3 (zeige LIG3 Proteine) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair

  10. results establish a role for Lig3 (zeige LIG3 Proteine) in mitochondria, but distinguish it from its interacting protein Xrcc1

XRCC1 Protein Überblick

Protein Überblick

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Alternative names and synonyms associated with XRCC1

  • X-ray repair complementing defective repair in Chinese hamster cells 1 (xrcc1)
  • X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1)
  • X-ray repair complementing defective repair in Chinese hamster cells 1 (Xrcc1)
  • MGC80909 Protein
  • RCC Protein
  • Xrcc-1 Protein
  • XRCC1 Protein

Bezeichner auf Proteinebene für XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1 , X-ray repair cross complementing protein 1 , DNA repair protein XRCC1-like , DNA repair protein XRCC1 , X-ray repair cross-complementing protein 1 , X-ray-repair, complementing defective, repair in Chinese hamster , x-ray repair cross-complementing group 1 protein

GENE ID SPEZIES
446884 Xenopus laevis
456094 Pan troglodytes
476447 Canis lupus familiaris
616905 Bos taurus
711457 Macaca mulatta
100380033 Xenopus (Silurana) tropicalis
100390129 Callithrix jacchus
100458994 Pongo abelii
100469866 Ailuropoda melanoleuca
100519604 Sus scrofa
100580597 Nomascus leucogenys
7515 Homo sapiens
22594 Mus musculus
84495 Rattus norvegicus
100689414 Cricetulus griseus
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