TP53BP1 Proteine (TP53BP1)

Bezeichnung:
Tumor Protein P53 Binding Protein 1 Proteine (TP53BP1)
Auf www.antikoerper-online.de finden Sie aktuell 3 Tumor Protein P53 Binding Protein 1 (TP53BP1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TP53BP1 Antikörper (233) und TP53BP1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 248 TP53BP1 Produkte verfügbar.
Synonyme:
53BP1, m53BP1, MGC160112, p202, Tp53bp1, Trp53bp1
alle Proteine anzeigen Gen GeneID UniProt
Maus TP53BP1 TP53BP1 27223 P70399
TP53BP1 7158 Q12888
Ratte TP53BP1 TP53BP1 296099  

Weitere Synonyme anzeigen

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Weitere Proteine zu TP53BP1 Interaktionspartnern

Mouse (Murine) Tumor Protein P53 Binding Protein 1 (TP53BP1) Interaktionspartner

  1. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (zeige RAD51 Proteine) and 53BP1 were recruited to these sites. H2AX (zeige H2AFX Proteine) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Proteine) foci formation and DSB repair, whereas H2AX (zeige H2AFX Proteine) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Proteine) foci were small and DSBs were not efficiently repaired

  2. Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (zeige SGMS1 Proteine) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.

  3. These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (zeige PRKDC Proteine)-deficient telomeres throughout the cell cycle.

  4. Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (zeige LMNA Proteine) deficiency, which was not observed for heterochromatin-related proteins HP1beta (zeige CBX1 Proteine) and BMI1 (zeige BMI1 Proteine).

  5. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (zeige E2F1 Proteine) target genes and allows pRb (zeige PGR Proteine) activity to be effectively integrated with the DNA damage response.

  6. study uncovers novel ATM (zeige ATM Proteine)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection

  7. Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP (zeige PAXIP1 Proteine).

  8. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination

  9. loss of 53BP1 alters the translocatome by increasing rearrangements to intergenic regions.

  10. A mutant lacking the oligomerization domain (53BP1(oligo)) was only modestly impaired in promoting NHEJ of dysfunctional telomeres and showed no defect with regard to the repression of CtIP (zeige RBBP8 Proteine).

Human Tumor Protein P53 Binding Protein 1 (TP53BP1) Interaktionspartner

  1. 53BP1 embodies two distinct activities: it can act as a DNA repair factor on the chromatin that flanks double-strand DNA repairs, and it promotes optimal p53 (zeige TP53 Proteine) activity.

  2. Ras-induced senescent cells are hindered in their ability to recruit BRCA1 and 53BP1 to DNA damage sites. Whereas BRCA1 is downregulated at transcripts levels, 53BP1 loss is caused by activation of cathepsin L (zeige CTSL1 Proteine)-mediated degradation of 53BP1 protein. we discovered a marked downregulation of vitamin D receptor (VDR) during OIS, and a role for the vitamin D/VDR (zeige CYP27B1 Proteine) axis regulating the levels of these DNA repair

  3. 53BP1-USP28 (zeige USP28 Proteine) cooperation is essential for normal p53 (zeige TP53 Proteine)-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation.

  4. TIP60 (zeige KAT5 Proteine) complex regulates bivalent chromatin recognition/modification by 53BP1 through direct H4K20me binding and H2AK15 acetylation.

  5. findings identify TIRR as a new factor that influences double-strand break repair using a unique mechanism of masking the histone methyl-lysine binding function of 53BP1

  6. Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer.

  7. interplay between 53BP1/NHEJ and BRCA1/HR is of great relevance for tumor treatment, as the 53BP1 status would be highly important for the treatment response of BRCA1-associated tumors.

  8. Exhaustion of 53BP1 by increasing the load of double strand breaks suppresses RAD51 (zeige RAD51 Proteine) accumulation in repair foci during S and G2.

  9. TIRR is a novel 53BP1-interacting protein that participates in the DNA damage response

  10. These data suggest that multiple pathways collectively fine-tune the cellular levels of 53BP1 protein to ensure proper DSB repair and cell survival.

TP53BP1 Protein Überblick

Protein Überblick

May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).

Alternative names and synonyms associated with TP53BP1

  • tumor protein p53 binding protein 1 (TP53BP1)
  • tumor protein p53 binding protein 1 (tp53bp1)
  • tumor protein p53 binding protein 1 (predicted), 5 prime (TP53BP1)
  • transformation related protein 53 binding protein 1 (Trp53bp1)
  • tumor protein p53 binding protein 1 (Tp53bp1)
  • 53BP1 Protein
  • m53BP1 Protein
  • MGC160112 Protein
  • p202 Protein
  • Tp53bp1 Protein
  • Trp53bp1 Protein

Bezeichner auf Proteinebene für TP53BP1

tumor protein p53 binding protein 1 , tumor protein p53 binding protein, 1 , tumor suppressor p53-binding protein 1-like , tumor protein p53 binding protein 1 (predicted), 5 prime , tumor protein p53 binding protein 1 (predicted), 3 prime , murine p53-binding protein , p53-binding protein 1 , p53BP1 , transformation related protein 53 binding-protein 1 , tumor suppressor p53-binding protein 1 , tumor protein 53-binding protein, 1 , tumor protein p53-binding protein, 1 , transformation related protein 53 binding protein 1

GENE ID SPEZIES
415589 Gallus gallus
467668 Pan troglodytes
478274 Canis lupus familiaris
509111 Bos taurus
100137429 Papio anubis
100468474 Ailuropoda melanoleuca
100490124 Xenopus (Silurana) tropicalis
100550605 Meleagris gallopavo
100607698 Nomascus leucogenys
100328680 Oryctolagus cuniculus
27223 Mus musculus
7158 Homo sapiens
296099 Rattus norvegicus
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