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anti-TP53BP1 (TP53BP1) Antikörper

anti-Tumor Protein P53 Binding Protein 1 Antikörper (TP53BP1)
Auf finden Sie aktuell 233 Tumor Protein P53 Binding Protein 1 (TP53BP1) Antikörper von 24 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TP53BP1 Kits (10) und TP53BP1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 248 TP53BP1 Produkte verfügbar.
53BP1, m53BP1, MGC160112, p202, Tp53bp1, Trp53bp1
Alle Antikörper anzeigen Gen GeneID UniProt
TP53BP1 27223 P70399
TP53BP1 7158 Q12888
TP53BP1 296099  

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-TP53BP1 (TP53BP1) Antikörper

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anti-Mouse (Murine) TP53BP1 Antikörper:

anti-Human TP53BP1 Antikörper:

anti-Rat (Rattus) TP53BP1 Antikörper:

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Am meisten referenzierte anti-TP53BP1 Antikörper

  1. Fish Polyclonal TP53BP1 Primary Antibody für ChIP, FACS - ABIN151770 : Riballo, Kühne, Rief, Doherty, Smith, Recio, Reis, Dahm, Fricke, Krempler, Parker, Jackson, Gennery, Jeggo, Löbrich: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. in Molecular cell 2004 (PubMed)
    Zeige alle 243 Referenzen für ABIN151770

  2. Human Polyclonal TP53BP1 Primary Antibody für ChIP, ICC - ABIN151771 : Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004 (PubMed)
    Zeige alle 66 Referenzen für ABIN151771

  3. Human Polyclonal TP53BP1 Primary Antibody für ICC, IF - ABIN152191 : Murga, Jaco, Fan, Soria, Martinez-Pastor, Cuadrado, Yang, Blasco, Skoultchi, Fernandez-Capetillo: Global chromatin compaction limits the strength of the DNA damage response. in The Journal of cell biology 2007 (PubMed)
    Zeige alle 62 Referenzen für ABIN152191

  4. Human Polyclonal TP53BP1 Primary Antibody für ICC, FACS - ABIN151311 : Kang, Lee, Hoan, Sohn, Chang, You: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 10 Referenzen für ABIN151311

  5. Human Monoclonal TP53BP1 Primary Antibody für BI, WB - ABIN968860 : Iwabuchi, Bartel, Li, Marraccino, Fields: Two cellular proteins that bind to wild-type but not mutant p53. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Zeige alle 3 Referenzen für ABIN968860

  6. Human Monoclonal TP53BP1 Primary Antibody für FACS, IHC - ABIN1724821 : Nakada, Yonamine, Matsuo: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. in Cancer research 2012 (PubMed)
    Zeige alle 2 Referenzen für ABIN1724821

  7. Human Polyclonal TP53BP1 Primary Antibody für IF (p), IHC (p) - ABIN682993 : Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. in The Journal of biological chemistry 2015 (PubMed)

Weitere Antikörper gegen TP53BP1 Interaktionspartner

Mouse (Murine) Tumor Protein P53 Binding Protein 1 (TP53BP1) Interaktionspartner

  1. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (zeige RAD51 Antikörper) and 53BP1 were recruited to these sites. H2AX (zeige H2AFX Antikörper) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Antikörper) foci formation and DSB repair, whereas H2AX (zeige H2AFX Antikörper) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Antikörper) foci were small and DSBs were not efficiently repaired

  2. Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (zeige SGMS1 Antikörper) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.

  3. These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (zeige PRKDC Antikörper)-deficient telomeres throughout the cell cycle.

  4. Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (zeige LMNA Antikörper) deficiency, which was not observed for heterochromatin-related proteins HP1beta (zeige CBX1 Antikörper) and BMI1 (zeige BMI1 Antikörper).

  5. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (zeige E2F1 Antikörper) target genes and allows pRb (zeige PGR Antikörper) activity to be effectively integrated with the DNA damage response.

  6. study uncovers novel ATM (zeige ATM Antikörper)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection

  7. Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (zeige RIF1 Antikörper) and PTIP (zeige PAXIP1 Antikörper).

  8. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination

  9. loss of 53BP1 alters the translocatome by increasing rearrangements to intergenic regions.

  10. A mutant lacking the oligomerization domain (53BP1(oligo)) was only modestly impaired in promoting NHEJ of dysfunctional telomeres and showed no defect with regard to the repression of CtIP (zeige RBBP8 Antikörper).

Human Tumor Protein P53 Binding Protein 1 (TP53BP1) Interaktionspartner

  1. Increased 53BP1 expression (i.e., "unstable" expression) in nuclear foci of oncocytic follicular adenoma (FA) of the thyroid correlates with a higher incidence of DNA copy numbers compared with conventional FA.

  2. High 53BP1 mRNA is associated with head and neck cancer.

  3. hese findings confirmed that 53BP1 loss might be a negative factor for chemotherapy efficacy, promoting cell proliferation and inhibiting apoptosis by suppressing ATM (zeige ATM Antikörper)-CHK2 (zeige CHEK2 Antikörper)-P53 (zeige TP53 Antikörper) signaling, and finally inducing 5-FU resistance.

  4. During live-cell imaging, 53BP1-GFP focus formation was observed within 10 minutes after UVC irradiation. Most 53BP1 foci resolved by 100 minutes. To block UVC-induced double-strand break repair in cancer cells, poly(ADP-ribose) polymerase (PARP (zeige PARP1 Antikörper)) was targeted with ABT-888 (veliparib). PARP (zeige COL11A2 Antikörper) inhibition markedly enhanced UVC-irradiation-induced persistence of 53BP1-foci

  5. Combined effect of dynamic recruitment of RNF4 to KAP1 regulates the relative occupancy of 53BP1 and BRCA1 at double-strand break sites to direct DNA repair in a cell cycle-dependent manner.

  6. the formation of 53BP1, gammaH2AX (zeige H2AFX Antikörper) foci and their co-localization induced by gamma-rays (2, 5, 10, 50, 200 cGy) in human lymphocytes, was analyzed.

  7. 5-Hydroxymethylcytosine (5hmC) accumulates at DNA damage foci and colocalizes with major DNA damage response proteins 53BP1 and gH2AX, revealing 5hmC as an epigenetic marker of DNA damage.

  8. we show that XIST and 53BP1 can be used to identify BRCA1-like breast cancer patients that have higher event rates and poor outcome after HD chemotherapy.

  9. kinetics of the accumulation of selected DNA repair-related proteins is protein specific at locally induced DNA lesions, and that the formation of gH2AX- and NBS1 (zeige NBN Antikörper)-positive foci, but not 53BP1-positive NBs (zeige NBN Antikörper), is cell cycle dependent in HeLa cells

  10. the interaction of 53BP1 with gammaH2AX (zeige H2AFX Antikörper) is required for sustaining the 53BP1-dependent focal concentration of activated ATM (zeige ATM Antikörper) that facilitates repair of DNA double-strand breaks in heterochromatin in G1.

TP53BP1 Antigen-Profil

Beschreibung des Gens

May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).

Alternative names and synonyms associated with TP53BP1

  • tumor protein p53 binding protein 1 (TP53BP1) Antikörper
  • tumor protein p53 binding protein 1 (tp53bp1) Antikörper
  • tumor protein p53 binding protein 1 (predicted), 5 prime (TP53BP1) Antikörper
  • transformation related protein 53 binding protein 1 (Trp53bp1) Antikörper
  • tumor protein p53 binding protein 1 (Tp53bp1) Antikörper
  • 53BP1 Antikörper
  • m53BP1 Antikörper
  • MGC160112 Antikörper
  • p202 Antikörper
  • Tp53bp1 Antikörper
  • Trp53bp1 Antikörper

Bezeichner auf Proteinebene für TP53BP1

tumor protein p53 binding protein 1 , tumor protein p53 binding protein, 1 , tumor suppressor p53-binding protein 1-like , tumor protein p53 binding protein 1 (predicted), 5 prime , tumor protein p53 binding protein 1 (predicted), 3 prime , murine p53-binding protein , p53-binding protein 1 , p53BP1 , transformation related protein 53 binding-protein 1 , tumor suppressor p53-binding protein 1 , tumor protein 53-binding protein, 1 , tumor protein p53-binding protein, 1 , transformation related protein 53 binding protein 1

415589 Gallus gallus
467668 Pan troglodytes
478274 Canis lupus familiaris
509111 Bos taurus
100137429 Papio anubis
100468474 Ailuropoda melanoleuca
100490124 Xenopus (Silurana) tropicalis
100550605 Meleagris gallopavo
100607698 Nomascus leucogenys
100328680 Oryctolagus cuniculus
27223 Mus musculus
7158 Homo sapiens
296099 Rattus norvegicus
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