anti-TP53BP1 (TP53BP1) Antikörper

anti-Tumor Protein P53 Binding Protein 1 Antikörper (TP53BP1)
Auf finden Sie aktuell 239 Tumor Protein P53 Binding Protein 1 (TP53BP1) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TP53BP1 Kits (10) und TP53BP1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 254 TP53BP1 Produkte verfügbar.
53BP1, m53BP1, MGC160112, p202, Tp53bp1, Trp53bp1
Alle Antikörper anzeigen Gen GeneID UniProt
TP53BP1 27223 P70399
TP53BP1 7158 Q12888
TP53BP1 296099  

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Meistgesuchte Reaktivitäten zu anti-TP53BP1 (TP53BP1) Antikörper

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anti-Mouse (Murine) TP53BP1 Antikörper:

anti-Human TP53BP1 Antikörper:

anti-Rat (Rattus) TP53BP1 Antikörper:

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Am meisten referenzierte anti-TP53BP1 Antikörper

  1. Fish Polyclonal TP53BP1 Primary Antibody für ChIP, FACS - ABIN151770 : Riballo, Kühne, Rief, Doherty, Smith, Recio, Reis, Dahm, Fricke, Krempler, Parker, Jackson, Gennery, Jeggo, Löbrich: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. in Molecular cell 2004 (PubMed)
    Zeige alle 272 Referenzen für 151770

  2. Human Polyclonal TP53BP1 Primary Antibody für ChIP, ICC - ABIN151771 : Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004 (PubMed)
    Zeige alle 70 Referenzen für 151771

  3. Human Polyclonal TP53BP1 Primary Antibody für ICC, IF - ABIN152191 : Murga, Jaco, Fan, Soria, Martinez-Pastor, Cuadrado, Yang, Blasco, Skoultchi, Fernandez-Capetillo: Global chromatin compaction limits the strength of the DNA damage response. in The Journal of cell biology 2007 (PubMed)
    Zeige alle 65 Referenzen für 152191

  4. Human Polyclonal TP53BP1 Primary Antibody für ICC, FACS - ABIN151311 : Kang, Lee, Hoan, Sohn, Chang, You: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. in The Journal of biological chemistry 2009 (PubMed)
    Zeige alle 11 Referenzen für 151311

  5. Human Monoclonal TP53BP1 Primary Antibody für BI, WB - ABIN968860 : Iwabuchi, Bartel, Li, Marraccino, Fields: Two cellular proteins that bind to wild-type but not mutant p53. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Zeige alle 3 Referenzen für 968860

  6. Human Monoclonal TP53BP1 Primary Antibody für FACS, IHC - ABIN1724821 : Nakada, Yonamine, Matsuo: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. in Cancer research 2012 (PubMed)
    Zeige alle 2 Referenzen für 1724821

  7. Human Polyclonal TP53BP1 Primary Antibody für IF (p), IHC (p) - ABIN682993 : Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. in The Journal of biological chemistry 2015 (PubMed)

Weitere Antikörper gegen TP53BP1 Interaktionspartner

Mouse (Murine) Tumor Protein P53 Binding Protein 1 (TP53BP1) Interaktionspartner

  1. this study shows that 53BP1 is required for three-dimensional organization of the immunoglobulin heavy chain locus and provides a plausible explanation for the link with 53BP1 enforcement of deletional immunoglobulin class switch recombination

  2. Genomic instability can be rescued by the deletion of Trp53bp1, which encodes the DNA damage response factor 53BP1, and mice expressing RING-less BRCA1 (zeige BRCA1 Antikörper) do not show an increased susceptibility to tumors in the absence of 53BP1.

  3. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (zeige RAD51 Antikörper) and 53BP1 were recruited to these sites. H2AX (zeige H2AFX Antikörper) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Antikörper) foci formation and DSB repair, whereas H2AX (zeige H2AFX Antikörper) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Antikörper) foci were small and DSBs were not efficiently repaired

  4. Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (zeige SGMS1 Antikörper) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.

  5. These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (zeige PRKDC Antikörper)-deficient telomeres throughout the cell cycle.

  6. Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (zeige LMNA Antikörper) deficiency, which was not observed for heterochromatin-related proteins HP1beta (zeige CBX1 Antikörper) and BMI1 (zeige BMI1 Antikörper).

  7. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (zeige E2F1 Antikörper) target genes and allows pRb (zeige PGR Antikörper) activity to be effectively integrated with the DNA damage response.

  8. study uncovers novel ATM (zeige ATM Antikörper)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection

  9. Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (zeige RIF1 Antikörper) and PTIP (zeige PAXIP1 Antikörper).

  10. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination

Human Tumor Protein P53 Binding Protein 1 (TP53BP1) Interaktionspartner

  1. Results provide evidence that 53BP1 is involved in breast cancer cells resistance for PARP (zeige COL11A2 Antikörper) inhibitor; its depletion causes resistance in ATM (zeige ATM Antikörper)-deficient tumor cells.

  2. Ubiquitin ligases RNF168 (zeige RNF168 Antikörper), RNF169 (zeige RNF169 Antikörper), and RAD18 (zeige RAD18 Antikörper) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 chromatin recruitment may be activated by RNF168 (zeige RNF168 Antikörper) and blocked by RNF169 (zeige RNF169 Antikörper) and RAD18 (zeige RAD18 Antikörper).

  3. 53BP1 embodies two distinct activities: it can act as a DNA repair factor on the chromatin that flanks double-strand DNA repairs, and it promotes optimal p53 (zeige TP53 Antikörper) activity.

  4. Ras-induced senescent cells are hindered in their ability to recruit BRCA1 and 53BP1 to DNA damage sites. Whereas BRCA1 is downregulated at transcripts levels, 53BP1 loss is caused by activation of cathepsin L (zeige CTSL1 Antikörper)-mediated degradation of 53BP1 protein. we discovered a marked downregulation of vitamin D receptor (VDR) during OIS, and a role for the vitamin D/VDR (zeige CYP27B1 Antikörper) axis regulating the levels of these DNA repair

  5. 53BP1-USP28 (zeige USP28 Antikörper) cooperation is essential for normal p53 (zeige TP53 Antikörper)-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation.

  6. TIP60 (zeige KAT5 Antikörper) complex regulates bivalent chromatin recognition/modification by 53BP1 through direct H4K20me binding and H2AK15 acetylation.

  7. findings identify TIRR as a new factor that influences double-strand break repair using a unique mechanism of masking the histone methyl-lysine binding function of 53BP1

  8. Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer.

  9. interplay between 53BP1/NHEJ and BRCA1/HR is of great relevance for tumor treatment, as the 53BP1 status would be highly important for the treatment response of BRCA1-associated tumors.

  10. Exhaustion of 53BP1 by increasing the load of double strand breaks suppresses RAD51 (zeige RAD51 Antikörper) accumulation in repair foci during S and G2.

TP53BP1 Antigen-Profil

Beschreibung des Gens

May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).

Alternative names and synonyms associated with TP53BP1

  • tumor protein p53 binding protein 1 (TP53BP1) Antikörper
  • tumor protein p53 binding protein 1 (tp53bp1) Antikörper
  • tumor protein p53 binding protein 1 (predicted), 5 prime (TP53BP1) Antikörper
  • transformation related protein 53 binding protein 1 (Trp53bp1) Antikörper
  • tumor protein p53 binding protein 1 (Tp53bp1) Antikörper
  • 53BP1 Antikörper
  • m53BP1 Antikörper
  • MGC160112 Antikörper
  • p202 Antikörper
  • Tp53bp1 Antikörper
  • Trp53bp1 Antikörper

Bezeichner auf Proteinebene für TP53BP1

tumor protein p53 binding protein 1 , tumor protein p53 binding protein, 1 , tumor suppressor p53-binding protein 1-like , tumor protein p53 binding protein 1 (predicted), 5 prime , tumor protein p53 binding protein 1 (predicted), 3 prime , murine p53-binding protein , p53-binding protein 1 , p53BP1 , transformation related protein 53 binding-protein 1 , tumor suppressor p53-binding protein 1 , tumor protein 53-binding protein, 1 , tumor protein p53-binding protein, 1 , transformation related protein 53 binding protein 1

415589 Gallus gallus
467668 Pan troglodytes
478274 Canis lupus familiaris
509111 Bos taurus
100137429 Papio anubis
100468474 Ailuropoda melanoleuca
100490124 Xenopus (Silurana) tropicalis
100550605 Meleagris gallopavo
100607698 Nomascus leucogenys
100328680 Oryctolagus cuniculus
27223 Mus musculus
7158 Homo sapiens
296099 Rattus norvegicus
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