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DNA-bound RAD52 is efficient at capturing ssDNA in trans.
Structure of the human DNA-repair protein RAD52 containing surface mutations has been reported.
Rad52 inverse strand exchange plays an important role in RNA-templated double strand break repair in vivo.
The mitotic DNA synthesis is RAD52 dependent, and RAD52 is required for the timely recruitment of MUS81 (zeige MUS81 Proteine) and POLD3 (zeige POLD3 Proteine) to common fragile sites in early mitosis.
Human RAD52-null cells retain a significant level of single-strand annealing (SSA (zeige TRIM21 Proteine)) activity demonstrating perforce that additional SSA (zeige TRIM21 Proteine)-like activities must exist in human cells. Moreover, the SSA (zeige TRIM21 Proteine) activity associated with RAD52 is involved in, but not absolutely required for, most homology-directed repair (HDR (zeige GATA3 Proteine)) subpathways. Specifically, a deficiency in RAD52 impaired the repair of DNA DSBs.
Data suggest RAD52 binds tightly to RPA (zeige RPA1 Proteine)/ssDNA complex in presynaptic complex and inhibits RPA (zeige RPA1 Proteine) turnover; during presynaptic complex assembly, most of RPA (zeige RPA1 Proteine) and RAD52 is displaced from ssDNA, but some RAD52/RPA (zeige RPA1 Proteine)/ssDNA complexes persist as interspersed clusters surrounded by RAD51 (zeige RAD51 Proteine) filaments. (RAD52 = Rad52 DNA repair/recombination protein (zeige RAD50 Proteine); RPA (zeige RPA1 Proteine) = replication protein A (zeige GPR153 Proteine); ssDNA = single-stranded DNA; RAD51 (zeige RAD51 Proteine) = Rad51 (zeige RAD51 Proteine) recombinase (zeige RAG1 Proteine))
The C-terminal region of yRad52, but not of hRAD52, is involved in ssDNA annealing. This suggests that the second DNA binding site is required for the efficient ssDNA annealing by yRad52. We propose an updated model of Rad52-mediated ssDNA annealing.
Study discovered two cis (zeige CISH Proteine)-expression quantitative trait loci SNPs in the RAD52 gene that are associated with its expression and are also associated with lung squamous cell carcinomas (LUSC) risk.
BRG1 (zeige SMARCA4 Proteine)-RAD52 complex mediates the replacement of RPA (zeige RPA1 Proteine) with RAD51 (zeige RAD51 Proteine) on single-stranded DNA (ssDNA) to initiate DNA strand invasion. Loss of BRG1 (zeige SMARCA4 Proteine) results in a failure of RAD51 (zeige RAD51 Proteine) loading onto ssDNA, abnormal homologous recombination repair
these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of upper aerodigestive tract and lung squamous cell carcinoma tumors.
In cancer-prone, heterozygous APC (zeige APC Proteine) mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan.
Rad54 (zeige RAD54L Proteine) has a key function in maintaining genomic integrity of the developing germ cells.
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm (zeige ATM Proteine)-deficient mice.
RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events
Inactivation of RAD52 aggravates X-ray and mitomycine C sensitivity in mice with RAD54 (zeige RAD54L Proteine) gene degect.
Cells expressing Rad52 splice variants favor sister chromatid repair.
Results indicate that RAD52 cooperates with OGG1 (zeige OGG1 Proteine) to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress.
The complete cDNA sequences of the pig RAD51 (zeige RAD51 Proteine), RAD52, and RAD54 (zeige RAD54L Proteine) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Rad51 (zeige RAD51 Proteine) and Rad52 physically interact with CENP-ACaCse4 in vivo.
Rad52 prevents chromosome loss and truncation.
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair.
DNA repair protein RAD52 homolog
, recombination protein RAD52
, rhabdomyosarcoma antigen MU-RMS-40.23
, RAD52 homolog (S. cerevisiae)
, RAD52 homolog isoform alpha
, DNA repair protein RAD52
, DNA repair protein RAD52 homolog-like
, RAD52 homolog
, potential dsDNA break repair annealing factor
, DNA repair and recombination protein, putative
, RAD52 protein