anti-PMS2 (PMS2) Antikörper

anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) Antikörper (PMS2)
Auf finden Sie aktuell 104 PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Antikörper von 22 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PMS2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 117 PMS2 Produkte verfügbar.
AW555130, HNPCC4, PMS2CL, Pmsl2
Alle Antikörper anzeigen Gen GeneID UniProt
PMS2 5395 P54278
PMS2 18861  
PMS2 288479  

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Meistgesuchte Reaktivitäten zu anti-PMS2 (PMS2) Antikörper

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anti-Human PMS2 Antikörper:

anti-Mouse (Murine) PMS2 Antikörper:

anti-Rat (Rattus) PMS2 Antikörper:

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Am meisten referenzierte anti-PMS2 Antikörper

  1. Chimpanzee Monoclonal PMS2 Primary Antibody für EIA, IP - ABIN400795 : Wang, Cortez, Yazdi, Neff, Elledge, Qin: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. in Genes & development 2000 (PubMed)
    Zeige alle 7 Referenzen für 400795

  2. Human Monoclonal PMS2 Primary Antibody für IF, IP - ABIN967525 : Cleaver: It was a very good year for DNA repair. in Cell 1994 (PubMed)
    Zeige alle 5 Referenzen für 967525

  3. Human Polyclonal PMS2 Primary Antibody für ELISA, WB - ABIN1534484 : Nicolaides, Papadopoulos, Liu, Wei, Carter, Ruben, Rosen, Haseltine, Fleischmann, Fraser: Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. in Nature 1994 (PubMed)
    Zeige alle 2 Referenzen für 1534484

  4. Cow (Bovine) Polyclonal PMS2 Primary Antibody für WB - ABIN2786522 : Jackson, Holter, Pollett, Clendenning, Chou, Senter, Ramphal, Gallinger, Boycott: Café-au-lait macules and pediatric malignancy caused by biallelic mutations in the DNA mismatch repair (MMR) gene PMS2. in Pediatric blood & cancer 2008 (PubMed)

Weitere Antikörper gegen PMS2 Interaktionspartner

Human PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Interaktionspartner

  1. Data suggest that yeast Mlh1 (zeige MLH1 Antikörper)-Mlh3 (zeige MLH3 Antikörper) heterodimer does not exhibit hallmarks of a canonical (structure-selective) Holliday junction resolvase/endonuclease; multiple Mlh1 (zeige MLH1 Antikörper)-Mlh3 (zeige MLH3 Antikörper) heterodimers appear to load onto DNA to form an activated polymer that cleaves DNA; human MLH1 (zeige MLH1 Antikörper)-PMS2 exhibits similar characteristics. (MLH = mutL homolog protein; PMS2 = post meiotic segregation increased 2 protein)

  2. In an individual with mismatch repair deficiency syndrome, PMS2 was found to be homozygously inactivated by a complex chromosomal rearrangement.

  3. show that DNA repair genes (fan1 (zeige FSCN1 Antikörper) and pms2) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats

  4. The results of this case study indicated that although FOXL2 (zeige FOXL2 Antikörper) 402C > G mutation determines the development of granulosa cell tumor, PMS2 mutation may be the initial driver of carcinogenesis. Immunohistochemistry-based tumor testing for mismatch repair gene expression may be necessary for granulosa cell tumors to determine their malignant potential or if they are part of Lynch syndrome.

  5. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (zeige MLH1 Antikörper) in 40%, MSH2 (zeige MSH2 Antikörper) in 36%, MSH6 (zeige MSH6 Antikörper) in 18% and PMS2 in 6% of the families.

  6. molecular mechanisms linking MMR (zeige MRC1 Antikörper) with chemoresistance and suggest that stabilization of PMS2 expression may be useful in overcoming the cisplatin resistance in EOC.

  7. PMS2 mutation carriers with retention of RNA expression developed CRC (zeige CALR Antikörper) 9 years later than those with loss of RNA expression. If confirmed, this finding would justify a delay in surveillance for these cases. Cancer risk was not influenced by a parent-of-origin effect

  8. Individuals who carry a MMR (zeige MRC1 Antikörper) gene (MLH1 (zeige MLH1 Antikörper), MSH2 (zeige MSH2 Antikörper), PMS2 or MSH6 (zeige MSH6 Antikörper)) mutation are at an increased risk of developing cancers at multiple sites, most notably colorectal and endometrial carcinomas.

  9. Germline mutations in MLH1 (zeige MLH1 Antikörper), MSH2 (zeige MSH2 Antikörper), MSH6 (zeige MSH6 Antikörper) and PMS2 have been shown to cause Lynch syndrome. A total of 234 monoallelic PMS2 mutation carriers from 170 families were included.

  10. Loss of MLH-1 (zeige MLH1 Antikörper)/PMS-2 expression was associated with right-colon location, poor and mucinous differentiation and dense lymphocytic infiltration in colorectal adenocarcinoma.

Mouse (Murine) PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Interaktionspartner

  1. Pms2/Mlh1 (zeige MLH1 Antikörper) and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases.

  2. Primary function of Pms2 during spermatogenesis is to stabilize Mlh1 (zeige MLH1 Antikörper) levels prior to its critical crossing over function with Mlh3 (zeige MLH3 Antikörper). An intact Pms2 ATPase (zeige DNAH8 Antikörper) domain is not essential for male fertility.

  3. Pms2 specifically suppresses large expansions of a pathogenic trinucleotide repeat sequence in neuronal tissues, possibly acting independently of the canonical mismatch repair pathway.

  4. Down-regulation of PMS2 is associated with initiation and growth of neuroblastoma (zeige ARHGEF16 Antikörper) and brain tumour multicellular spheroids.

  5. the integrity of the MLH1 (zeige MLH1 Antikörper) ATPase (zeige DNAH8 Antikörper) domain is more critical than the PMS2 ATPase (zeige DNAH8 Antikörper) domain for normal DNA mismatch repair functions

  6. Data show that the PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance and tumor suppression.

  7. Role for mismatch repair proteins Msh2 (zeige MSH2 Antikörper), Mlh1 (zeige MLH1 Antikörper), and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.

  8. We found that MLH1 (zeige MLH1 Antikörper) and PMS2 have functional nuclear localization signals (NLS (zeige ALDH1A2 Antikörper)) and nuclear export sequences, yet nuclear import depended on their C-terminal dimerization to form MutLalpha

  9. Pms2 has a role in the prevention of tandem CC --> TT substitutions induced by ultraviolet radiation and oxidative stress.

  10. Data show partial functional redundancy between MLH3 (zeige MLH3 Antikörper) and PMS2 orthologues for mutation avoidance and show a role for Mlh3 (zeige MLH3 Antikörper) in gastrointestinal and extragastrointestinal tumor suppression.

PMS2 Antigen-Profil

Beschreibung des Gens

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with PMS2

  • PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2) Antikörper
  • mismatch repair endonuclease PMS2 (Tsp_08837) Antikörper
  • postmeiotic segregation increased 2 (S. cerevisiae) (Pms2) Antikörper
  • AW555130 Antikörper
  • HNPCC4 Antikörper
  • PMS2CL Antikörper
  • Pmsl2 Antikörper

Bezeichner auf Proteinebene für PMS2

mismatch repair endonuclease PMS2 , DNA mismatch repair protein PMS2 , H_DJ0042M02.9 , PMS1 protein homolog 2 , PMS2 postmeiotic segregation increased 2

479751 Canis lupus familiaris
100514342 Sus scrofa
10897854 Trichinella spiralis
5395 Homo sapiens
463257 Pan troglodytes
101752182 Gallus gallus
527039 Bos taurus
18861 Mus musculus
288479 Rattus norvegicus
Ausgewählte Anbieter für anti-PMS2 (PMS2) Antikörper
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