Poly (ADP-Ribose) Polymerase 2 Proteine (PARP2)

Bezeichnung:
Poly (ADP-Ribose) Polymerase 2 Proteine (PARP2)
Auf www.antikoerper-online.de finden Sie aktuell 7 Poly (ADP-Ribose) Polymerase 2 (PARP2) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Poly (ADP-Ribose) Polymerase 2 Antikörper (92) und Poly (ADP-Ribose) Polymerase 2 Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 111 Poly (ADP-Ribose) Polymerase 2 Produkte verfügbar.
Synonyme:
Adprt2, Adprtl2, ADPRTL3, ARTD2, Aspartl2, ATPARP1, C78626, cb996, F16D14.16, F16D14_16, pADPRT-2, PARP-2, poly(ADP-ribose) polymerase 1
alle Proteine anzeigen Gen GeneID UniProt
PARP2 10038 Q9UGN5
Ratte PARP2 PARP2 290027  
PARP2 11546 O88554

Weitere Synonyme anzeigen

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Am meisten referenzierte Poly (ADP-Ribose) Polymerase 2 Proteine

  1. Human PARP2 Protein expressed in Escherichia coli (E. coli) - ABIN1098789 : Karlberg, Hammarström, Schütz, Svensson, Schüler: Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888. in Biochemistry 2010 (PubMed)
    Zeige alle 2 Referenzen für 1098789

Weitere Proteine zu Poly (ADP-Ribose) Polymerase 2 Interaktionspartnern

Human Poly (ADP-Ribose) Polymerase 2 (PARP2) Interaktionspartner

  1. either PARP1 (zeige PARP1 Proteine) or PARP2 are sufficient for near-normal XRCC1 (zeige XRCC1 Proteine) recruitment at oxidative single-strand breaks

  2. Studies indicate that poly(ADP-ribose) polymerase 2 (PARP2) is involved in the differentiation of several cell types, including erythrocytes, T cells and adipocytes.

  3. Findings indicate that Increased poly(ADP-ribose) polymerase-2 (PARP-2) expression and loss of micrRNA miR (zeige MLXIP Proteine)-149 expression are involved in the pathogenesis of hepatocellular carcinomas (HCC (zeige FAM126A Proteine)) and are poor prognosis factors in patients with HCC (zeige FAM126A Proteine).

  4. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (zeige PARP1 Proteine)/2 and tankyrase 1 (zeige TNKS Proteine)/2 inhibitor which has the advantage of targeting Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling addicted tumors.

  5. The initial affinity between the PARP1 (zeige PARP1 Proteine), PARP2 and the DNA damaged site appears to influence both the size of the Poly(ADP-Ribose) synthesized and the time of residence of PARylated PARP1 (zeige PARP1 Proteine) and PARP2 on DNA damages.

  6. Our data suggest for the first time that a SNP in PARP2, rs878156, may together with other genetic variants modulate cancer specific survival in breast cancer patients depending on chemotherapy

  7. Our study differentiates the functions of PARP-2 domains from those of PARP-1 (zeige PARP1 Proteine), the other major DDR (zeige DDR1 Proteine)-PARP, and highlights the specialization of the multi-domain architectures of DDR (zeige DDR1 Proteine)-PARPs.

  8. Interaction of PARP-2 with AP site containing DNA

  9. Identification of ADP-ribosylation sites in PARP2 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed.

  10. Nuclear Smad (zeige SMAD1 Proteine) function is negatively regulated by PARP-1 (zeige PARP1 Proteine) that is assisted by PARP-2 and positively regulated by PARG (zeige PARG Proteine) during the course of TGFB (zeige TGFB1 Proteine) signaling.

Mouse (Murine) Poly (ADP-Ribose) Polymerase 2 (PARP2) Interaktionspartner

  1. PARP1 (zeige PARP1 Proteine)/2 inhibitor simmiparib causes growth inhibition in cancer cell- or tissue-derived xenografts in nude mice.

  2. The findings highlight specific non-overlapping functions of PARP1 (zeige PARP1 Proteine) and PARP2 at H2AX (zeige H2AFX Proteine)-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 (zeige PARP1 Proteine) in nonhomologous end-joining-deficient cells.

  3. Data show reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 (zeige PARP1 Proteine) and PARP-2 knockout mice.

  4. PARP-2 has an essential role in erythropoiesis by limiting replicative stress in erythroid progenitors.

  5. PARP-1 (zeige PARP1 Proteine) and -2 play a role in cancer-induced cachexia, thus selective pharmacological inhibition of PARP-1 (zeige PARP1 Proteine) and -2 may be of interest in clinical settings

  6. the depletion of PARP-2 leads to lower HDL (zeige HSD11B1 Proteine) levels which represent a risk factor to cardiovascular diseases.

  7. This study represents the first description of a significant role for PARP-2 in neuroinflammation and neurological dysfunction in Experimental autoimmune encephalomyelitis

  8. our data show that PARP-2 can directly regulate base excision repair proteins

  9. Our results show that Parp-2 plays essential roles in the surveillance of genome integrity of stem cell hematopoiesis by orchestrating DNA repair and restraining p53 (zeige TP53 Proteine)-induced and Puma (zeige BBC3 Proteine)-mediated apoptosis.

  10. PARP2 activity mobilizes intracellular TRPM2 (zeige TRPM2 Proteine) channels in a Parp1 (zeige PARP1 Proteine)-/- background.

Arabidopsis thaliana Poly (ADP-Ribose) Polymerase 2 (PARP2) Interaktionspartner

  1. whilst all isoforms of PARP (zeige PARP1 Proteine) were localized to the nucleus they are also present in non-nuclear locations with parp1 and parp3 (zeige PARP3 Proteine) also localised in the cytosol, and parp2 also present in the mitochondria

  2. Studies indicate that a massive and rapid accumulation of a massive and rapid accumulation poly(ADP-ribose) polymerases AtPARP1 and AtPARP2 transcripts was observed upon treatment with ionizing radiation and reactive oxigen species (ROS (zeige ROS1 Proteine)).

  3. PARP (zeige PARP1 Proteine) isoforms play a minor role in telomere length maintenance in Arabidopsis.

  4. Evidence suggests a link between the glutathione pool and PARP (zeige PARP1 Proteine) expression and activity that is perhaps related to the distribution of intracellular glutathione between the cytoplasm and the nucleus. [PARP1]

  5. in PARP2-deficient Arabidopsis plants, the observed abiotic stress resistance can also be explained by alterations in abscisic acid levels that facilitate the induction of a wide set of defense-related genes

Poly (ADP-Ribose) Polymerase 2 (PARP2) Protein Überblick

Protein Überblick

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

Alternative names and synonyms associated with Poly (ADP-Ribose) Polymerase 2 (PARP2)

  • poly (ADP-ribose) polymerase family, member 2 (parp2)
  • poly (ADP-ribose) polymerase 2 (parp2)
  • poly (ADP-ribose) polymerase 2 (PARP2)
  • poly (ADP-ribose) polymerase 2 (Parp2)
  • poly (ADP-ribose) polymerase family, member 2 (Parp2)
  • poly [ADP-ribose] polymerase 2 (PARP1)
  • Adprt2 Protein
  • Adprtl2 Protein
  • ADPRTL3 Protein
  • ARTD2 Protein
  • Aspartl2 Protein
  • ATPARP1 Protein
  • C78626 Protein
  • cb996 Protein
  • F16D14.16 Protein
  • F16D14_16 Protein
  • pADPRT-2 Protein
  • PARP-2 Protein
  • poly(ADP-ribose) polymerase 1 Protein

Bezeichner auf Proteinebene für PARP2

poly (ADP-ribose) polymerase family, member 2 , ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2 , ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2 , poly [ADP-ribose] polymerase 2 , poly (ADP-ribose) polymerase 2 , poly [ADP-ribose] polymerase 2-like , ADP-ribosyltransferase diphtheria toxin-like 2 , ADPRT-2 , NAD(+) ADP-ribosyltransferase 2 , hPARP-2 , poly (ADP-ribosyl) transferase-like 2 , poly(ADP-ribose) synthetase , poly[ADP-ribose] synthase 2 , poly[ADP-ribose] synthetase 2 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2 , mPARP-2 , pADPRT-2

GENE ID SPEZIES
386773 Danio rerio
446370 Xenopus laevis
465197 Pan troglodytes
701955 Macaca mulatta
100452137 Pongo abelii
10038 Homo sapiens
475392 Canis lupus familiaris
505828 Bos taurus
290027 Rattus norvegicus
11546 Mus musculus
817690 Arabidopsis thaliana
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