Nibrin Proteine (NBN)

Bezeichnung:
Nibrin Proteine (NBN)
Auf www.antikoerper-online.de finden Sie aktuell 7 Nibrin (NBN) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Nibrin Antikörper (260) und Nibrin Kits (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 290 Nibrin Produkte verfügbar.
Synonyme:
AT-V1, AT-V2, ATV, im:6911679, NBN, NBS, Nbs1, P95, zgc:194152
alle Proteine anzeigen Gen GeneID UniProt
NBN 4683 O60934
NBN 27354 Q9R207
NBN 85482 Q9JIL9

Weitere Synonyme anzeigen

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Weitere Proteine zu Nibrin Interaktionspartnern

Human Nibrin (NBN) Interaktionspartner

  1. The results illuminate the important role of Nbs1 and CtIP (zeige RBBP8 Proteine) in determining the substrates and consequences of human Mre11 (zeige MRE11A Proteine)/Rad50 (zeige RAD50 Proteine) nuclease (zeige DCLRE1C Proteine) activities on protein-DNA lesions.

  2. The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.

  3. The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer

  4. surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination

  5. although Mre11 (zeige MRE11A Proteine) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (zeige MRE11A Proteine) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  6. a somatic missense mutation c.1061C>T (p.P354L) in the NBN gene in a patient with CCS (zeige CCS Proteine) lacking an EWSR1 (zeige EWSR1 Proteine)-ATF1 (zeige AFT1 Proteine) fusion.

  7. The high expression of MRE11 (zeige MRE11A Proteine)-RAD50 (zeige RAD50 Proteine)-NBS1 complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

  8. The overall frequency of c.657del5 in unselected pancreatic ductal adenocarcinoma (PDAC) patients (5/241; 2.07%) significantly differed from that in non-cancer controls (2/915; 0.2%; P=0.006). The result indicates that the NBN c.657del5 variant represents a novel PDAC-susceptibility allele increasing PDAC risk (OR=9.7; 95% CI: 1.9 to 50.2).

  9. mitochondria response to low-dose radiation in radiosensitive human ataxia telangiectasia mutated (ATM (zeige ATM Proteine))- and Nijmegen breakage syndrome (NBS)1-deficient cell lines, was investigated.

  10. Study shows that NBS1 may function in histone modification and in the coordination of chromatin remodeling to promote efficient and effective DNA double-strand break repair. [review]

Mouse (Murine) Nibrin (NBN) Interaktionspartner

  1. findings show that NBS1 is crucial for macrophage function during normal aging

  2. TRIP13 (zeige TRIP13 Proteine)-deficient spermatocytes also progress to an H1t (zeige HIST1H1T Proteine)-positive stage if ATM (zeige ATM Proteine) activity is attenuated by hypomorphic mutations in Mre11 (zeige MRE11A Proteine) or Nbs1 or by elimination of the ATM (zeige ATM Proteine)-effector kinase CHK2 (zeige CHEK2 Proteine)

  3. In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate.

  4. Nbs1 mutants initially accumulate replication intermediate, not DSBs.

  5. This report showed that ATM (zeige ATM Proteine)-Chk2 (zeige CHEK2 Proteine)-P53 (zeige TP53 Proteine) signaling pathway and the AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes.

  6. JNK (zeige MAPK8 Proteine) signaling and ATR signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice.

  7. Nbn and Atm (zeige ATM Proteine) collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.

  8. the antagonism and redundancy of ATMIN (zeige ATMIN Proteine) and NBS1 constitute a crucial regulatory mechanism for ATM (zeige ATM Proteine) signaling and function.

  9. Nbs1-deficient neocortex shows accumulative endogenous DNA damage and defective activation of Ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway upon DNA damage.

  10. NBS1 haploinsufficiency results in increased mammary tumor latency and metastasis.

Nibrin (NBN) Protein Überblick

Protein Überblick

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Alternative names and synonyms associated with Nibrin (NBN)

  • nibrin (NBN)
  • nibrin (nbn)
  • nibrin (Nbn)
  • AT-V1 Protein
  • AT-V2 Protein
  • ATV Protein
  • im:6911679 Protein
  • NBN Protein
  • NBS Protein
  • Nbs1 Protein
  • P95 Protein
  • zgc:194152 Protein

Bezeichner auf Proteinebene für Nibrin Proteine (NBN)

nibrin , Nijmegen breakage syndrome 1 (nibrin) , cell cycle regulatory protein p95 , p95 protein of the MRE11/RAD50 complex , nijmegen breakage syndrome protein 1 homolog

GENE ID SPEZIES
464278 Pan troglodytes
522943 Bos taurus
100480000 Ailuropoda melanoleuca
100526779 Papio anubis
100557161 Anolis carolinensis
100585384 Nomascus leucogenys
4683 Homo sapiens
27354 Mus musculus
85482 Rattus norvegicus
374246 Gallus gallus
100715565 Cavia porcellus
544655 Danio rerio
100172091 Pongo abelii
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