anti-Nibrin (NBN) Antikörper

anti-Nibrin Antikörper (NBN)
Auf finden Sie aktuell 269 Nibrin (NBN) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Nibrin Kits (11) und Nibrin Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 299 Nibrin Produkte verfügbar.
AT-V1, AT-V2, ATV, im:6911679, NBN, NBS, Nbs1, P95, zgc:194152

Meistgesuchte Reaktivitäten zu anti-Nibrin (NBN) Antikörper

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anti-Human Nibrin Antikörper:

anti-Mouse (Murine) Nibrin Antikörper:

anti-Rat (Rattus) Nibrin Antikörper:

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Am meisten referenzierte anti-Nibrin Antikörper

  1. Human Monoclonal Nibrin Primary Antibody für WB - ABIN394539 : Jelonek, Gdowicz-Klosok, Pietrowska, Borkowska, Korfanty, Rzeszowska-Wolny, Widlak: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. in Journal of applied genetics 2010 (PubMed)
    Zeige alle 5 Referenzen für 394539

  2. Human Polyclonal Nibrin Primary Antibody für WB - ABIN196714 : Hsu, Shi, Gartenhaus: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. in Oncogene 2005 (PubMed)
    Zeige alle 4 Referenzen für 196714

  3. Human Polyclonal Nibrin Primary Antibody für WB - ABIN197200 : Falck, Coates, Jackson: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. in Nature 2005 (PubMed)
    Zeige alle 4 Referenzen für 197200

  4. Human Polyclonal Nibrin Primary Antibody für FACS, IF - ABIN655721 : Liu, Shete, Wang, El-Zein, Etzel, Liang, Armstrong, Tsavachidis, Gilbert, Aldape, Xing, Wu, Wei, Bondy: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. in Carcinogenesis 2010 (PubMed)
    Zeige alle 3 Referenzen für 655721

  5. Human Monoclonal Nibrin Primary Antibody für ICC, FACS - ABIN1724942 : Zheng, Zhang, Jiang, You, Liu, Lu, Zhou: Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. in Molecular carcinogenesis 2011 (PubMed)
    Zeige alle 2 Referenzen für 1724942

  6. Human Polyclonal Nibrin Primary Antibody für ELISA, WB - ABIN1534475 : Varon, Vissinga, Platzer, Cerosaletti, Chrzanowska, Saar, Beckmann, Seemanová, Cooper, Nowak, Stumm, Weemaes, Gatti, Wilson, Digweed, Rosenthal, Sperling, Concannon, Reis: Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. in Cell 1998 (PubMed)
    Zeige alle 2 Referenzen für 1534475

  7. Human Polyclonal Nibrin Primary Antibody für IF, ELISA - ABIN1531747 : Carney, Maser, Olivares, Davis, Le Beau, Yates, Hays, Morgan, Petrini: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. in Cell 1998 (PubMed)
    Zeige alle 2 Referenzen für 1531747

  8. Human Polyclonal Nibrin Primary Antibody für EIA, FACS - ABIN953701 : Kavitha, Choudhary, Raghavan, Muniyappa: Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. in Biochemical and biophysical research communications 2010 (PubMed)
    Zeige alle 2 Referenzen für 953701

Weitere Antikörper gegen Nibrin Interaktionspartner

Human Nibrin (NBN) Interaktionspartner

  1. Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)

  2. Mre11 (zeige MRE11A Antikörper)-Rad50 (zeige RAD50 Antikörper)-Nbs1 complex initiates DNA double strand break repair.

  3. Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.

  4. The results illuminate the important role of Nbs1 and CtIP (zeige RBBP8 Antikörper) in determining the substrates and consequences of human Mre11 (zeige MRE11A Antikörper)/Rad50 (zeige RAD50 Antikörper) nuclease (zeige DCLRE1C Antikörper) activities on protein-DNA lesions.

  5. The Nbs1 homologs that promote herpes simplex virus 1 infection also interact with the herpes simplex virus 1 ICP0 protein.

  6. The CC genotype of NBS1 Glu185Gln may increase lung cancer risk only for males and smokers and may serve as a practical marker for early detective and predictive purposes of lung cancer

  7. surmise that the higher fertility of female c.657del5 carriers reflects a lower miscarriage rate in these women, thereby reflecting the role of the NBN gene product, nibrin, in the repair of DNA double strand breaks and their processing in immune gene rearrangements, telomere maintenance, and meiotic recombination

  8. although Mre11 (zeige MRE11A Antikörper) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (zeige MRE11A Antikörper) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  9. a somatic missense mutation c.1061C>T (p.P354L) in the NBN gene in a patient with CCS (zeige CCS Antikörper) lacking an EWSR1 (zeige EWSR1 Antikörper)-ATF1 (zeige AFT1 Antikörper) fusion.

  10. The high expression of MRE11 (zeige MRE11A Antikörper)-RAD50 (zeige RAD50 Antikörper)-NBS1 complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

Mouse (Murine) Nibrin (NBN) Interaktionspartner

  1. Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired.

  2. findings show that NBS1 is crucial for macrophage function during normal aging

  3. TRIP13 (zeige TRIP13 Antikörper)-deficient spermatocytes also progress to an H1t (zeige HIST1H1T Antikörper)-positive stage if ATM (zeige ATM Antikörper) activity is attenuated by hypomorphic mutations in Mre11 (zeige MRE11A Antikörper) or Nbs1 or by elimination of the ATM (zeige ATM Antikörper)-effector kinase CHK2 (zeige CHEK2 Antikörper)

  4. In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate.

  5. Nbs1 mutants initially accumulate replication intermediate, not DSBs.

  6. This report showed that ATM (zeige ATM Antikörper)-Chk2 (zeige CHEK2 Antikörper)-P53 (zeige TP53 Antikörper) signaling pathway and the AKT (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes.

  7. JNK (zeige MAPK8 Antikörper) signaling and ATR (zeige ATR Antikörper) signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice.

  8. Nbn and Atm (zeige ATM Antikörper) collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.

  9. the antagonism and redundancy of ATMIN (zeige ATMIN Antikörper) and NBS1 constitute a crucial regulatory mechanism for ATM (zeige ATM Antikörper) signaling and function.

  10. Nbs1-deficient neocortex shows accumulative endogenous DNA damage and defective activation of Ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway upon DNA damage.

Nibrin (NBN) Antigen-Profil

Beschreibung des Gens

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Alternative names and synonyms associated with Nibrin (NBN)

  • nibrin (NBN) Antikörper
  • nibrin (nbn) Antikörper
  • nibrin (Nbn) Antikörper
  • AT-V1 Antikörper
  • AT-V2 Antikörper
  • ATV Antikörper
  • im:6911679 Antikörper
  • NBN Antikörper
  • NBS Antikörper
  • Nbs1 Antikörper
  • P95 Antikörper
  • zgc:194152 Antikörper

Bezeichner auf Proteinebene für anti-Nibrin (NBN) Antikörper

nibrin , Nijmegen breakage syndrome 1 (nibrin) , cell cycle regulatory protein p95 , p95 protein of the MRE11/RAD50 complex , nijmegen breakage syndrome protein 1 homolog

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522943 Bos taurus
100480000 Ailuropoda melanoleuca
100526779 Papio anubis
100557161 Anolis carolinensis
100585384 Nomascus leucogenys
4683 Homo sapiens
27354 Mus musculus
85482 Rattus norvegicus
374246 Gallus gallus
100715565 Cavia porcellus
544655 Danio rerio
100172091 Pongo abelii
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