N-Methylpurine-DNA Glycosylase Proteine (MPG)

N-Methylpurine-DNA Glycosylase Proteine (MPG)
Auf www.antikoerper-online.de finden Sie aktuell 13 N-Methylpurine-DNA Glycosylase (MPG) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen N-Methylpurine-DNA Glycosylase Antikörper (107) und N-Methylpurine-DNA Glycosylase Kits (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 135 N-Methylpurine-DNA Glycosylase Produkte verfügbar.
9830006D05, Aag, ADPG, AI326268, anpg, APNG, BA3871, CRA36.1, MDG, Mid1, MPG, MPGR, PIG11, PIG16, si:xx-187g17.9, zgc:162984
alle Proteine anzeigen Gen GeneID UniProt
MPG 4350 P29372
MPG 268395 Q04841
MPG 24561  

Weitere Synonyme anzeigen

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Am meisten referenzierte N-Methylpurine-DNA Glycosylase Proteine

  1. Human MPG Protein expressed in Escherichia coli (E. coli) - ABIN667935 : Adhikari, Uren, Roy: Excised damaged base determines the turnover of human N-methylpurine-DNA glycosylase. in DNA repair 2009 (PubMed)
    Zeige alle 2 Referenzen für 667935

Weitere Proteine zu N-Methylpurine-DNA Glycosylase Interaktionspartnern

Human N-Methylpurine-DNA Glycosylase (MPG) Interaktionspartner

  1. Rheumatoid arthritis is associated with a polymorphism in the MPG gene (rs2858056) and increased serum level of the MPG protein.

  2. Role of MPG protein in the DNA damage response through the base excision repair pathway

  3. results suggest that individuals carrying R120C and R141Q MPG variants may be at risk for genomic instability and associated diseases as a consequence.

  4. Elevated MPG activity is associated with lung cancer, possibly by creating an imbalance in the base excision repair pathway.

  5. High MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk.

  6. disease-stage-specific alterations in the expression of MPG may highlight a potential role for MPG in determining EAC (zeige CYLD Proteine) onset and thus potentially be of clinical relevance for early disease detection and increased patient survival.

  7. AAG has a flexible amino terminus that tunes its affinity for nonspecific DNA, but we find that it is not required for intersegmental transfer. As AAG has only a single DNA binding site, this argues against the bridging model for intersegmental transfer

  8. AAG removes both methanol and 1,N(6)-ethenoadenine from DNA with single-turnover rate constants that are significantly greater than the corresponding uncatalyzed rates.

  9. Mitochondrial single-stranded binding protein (mtSSB (zeige SSBP1 Proteine)) as a novel interacting partner of AAG.

  10. UHRF1 (zeige UHRF1 Proteine) interacts with N-methylpurine DNA glycosylase (MPG) in cancer cells in vitro and displays a co-localization with MPG in the nucleoplasm.

Mouse (Murine) N-Methylpurine-DNA Glycosylase (MPG) Interaktionspartner

  1. The depletion of Aag (zeige C16orf35 Proteine) did not significantly change the transcriptional inhibitory or mutagenic properties of all five examined lesions, suggesting a negligible role of Aag (zeige C16orf35 Proteine) in the repair of these DNA adducts in mammalian cells.

  2. This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT (zeige MGMT Proteine), but not AAG (zeige C16orf35 Proteine), as a key node in determining a carcinogenic threshold.

  3. the detrimental effects of Aag (zeige C16orf35 Proteine)-initiated BER during I/R and sterile inflammation, and present a novel target for controlling I/R-induced injury.

  4. Toxicity, induced by tert (zeige TERT Proteine)-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (+/+), Nth1 (+/+)) and deficient (Mpg (-/-), Nth1 (-/-)) mouse embryonic fibroblasts following Msh2 (zeige MSH2 Proteine) knockdown, was examined.

  5. These results provide in vivo evidence that Aag (zeige C16orf35 Proteine)-initiated BER may play a critical role in determining the side-effects of alkylating agent chemotherapies and that Parp1 (zeige PARP1 Proteine) plays a crucial role in Aag (zeige C16orf35 Proteine)-mediated tissue damage.

  6. ALKBH2 (zeige ALKBH2 Proteine) and ALKBH3 (zeige ALKBH3 Proteine) provide cancer protection similar to that of the DNA glycosylase AAG (zeige C16orf35 Proteine) and display apparent epistasis with Aag (zeige C16orf35 Proteine)

  7. AAG (zeige C16orf35 Proteine) is a mammalian enzyme that can act on all three purine deamination bases, hypoxanthine, xanthine, and oxanine

  8. the N-terminal tail in MPG plays a critical role in overcoming product inhibition, which is achieved by reducing the differences of MPG binding affinity toward hypoxanthine and apurinic/apyrimidinic sites

  9. Aag (zeige C16orf35 Proteine)-mediated DNA repair prevents colonic epithelial damage and reduces the severity of dextran sulfate sodium-induced colon tumorigenesis.

  10. Aag (zeige C16orf35 Proteine)-initiated base excision repair drives alkylation-induced retinal degeneration.

N-Methylpurine-DNA Glycosylase (MPG) Protein Überblick

Protein Überblick

enzyme that cleaves 3-methyladenine and 7-methylguanine residues from DNA

Alternative names and synonyms associated with N-Methylpurine-DNA Glycosylase (MPG)

  • DNA-3-methyladenine glycosidase (alkA)
  • DNA-3-methyladenine glycosidase (CNL04530)
  • DNA-3-methyladenine glycosidase (cgd8_5410)
  • DNA-3-methyladenine glycosidase (Xfasm12_0684)
  • N-methylpurine-DNA glycosylase (MPG)
  • N-methylpurine-DNA glycosylase (mpg)
  • si:xx-by187g17.9 (si:xx-by187g17.9)
  • N-methylpurine-DNA glycosylase (CpB0526)
  • N-methylpurine-DNA glycosylase (gll2491)
  • N-methylpurine-DNA glycosylase (Mpg)
  • 9830006D05 Protein
  • Aag Protein
  • ADPG Protein
  • AI326268 Protein
  • anpg Protein
  • APNG Protein
  • BA3871 Protein
  • CRA36.1 Protein
  • MDG Protein
  • Mid1 Protein
  • MPG Protein
  • MPGR Protein
  • PIG11 Protein
  • PIG16 Protein
  • si:xx-187g17.9 Protein
  • zgc:162984 Protein

Bezeichner auf Proteinebene für MPG

DNA-3-methyladenine glycosidase , N-methylpurine-DNA glycosylase , DNA-3-methyladenine glycosylase , 3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p , 3-alkyladenine DNA glycosylase , 3-methyladenine DNA glycosidase , CRA36.1 (3-methyl-adenine DNA glycosylase) , N-methylpurine-DNA glycosylase, MPG , proliferation-inducing protein 11 , proliferation-inducing protein 16 , 3-methyladenine DNA glycosylase , ADPG , alkylpurine-DNA-N-glycosylase , N-methylpurine-DNA glycocylase

1088762 Bacillus anthracis str. Ames
1796118 Rhodopirellula baltica SH 1
3255007 Cryptococcus neoformans var. neoformans JEC21
3374666 Cryptosporidium parvum Iowa II
6119369 Xylella fastidiosa M12
416648 Gallus gallus
566516 Danio rerio
571211 Danio rerio
618306 Bos taurus
749794 Pan troglodytes
1467205 Chlamydophila pneumoniae TW-183
2600892 Gloeobacter violaceus PCC 7421
100579173 Sus scrofa
4350 Homo sapiens
611597 Canis lupus familiaris
268395 Mus musculus
24561 Rattus norvegicus
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