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Human MCM4 Protein expressed in Wheat germ - ABIN1310553
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
MCM4 and MCM7 (zeige MCM7 Proteine) expression is significantly correlated with Ki-67 (zeige MKI67 Proteine), Bmi1 (zeige BMI1 Proteine), and cyclin E (zeige CCNE1 Proteine) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin
Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4
Mutant p53 (zeige TP53 Proteine) depletion profoundly influenced PARP1 (zeige PARP1 Proteine) localization and increased the level of PCNA (zeige PCNA Proteine) and MCM4 proteins.
Of the total, the deregulation of several genes (CDK1 (zeige CDK1 Proteine), CDK2 (zeige CDK2 Proteine), CDK4 (zeige CDK4 Proteine), MCM2 (zeige MCM2 Proteine), MCM3 (zeige MCM3 Proteine), MCM4, EIF3a (zeige EIF6 Proteine) and RPN2 (zeige PSMD1 Proteine)) were potentially associated with disease development and progression.
Mcm2-7 (zeige MCM2 Proteine) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells
point mutation of MCM4 perturbs proper interaction with MCM6 (zeige MCM6 Proteine) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (zeige MCM2 Proteine) complex
Mutations in MCM4/PRKDC (zeige PRKDC Proteine) represent a novel cause of DNA breakage and NK cell deficiency.
Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.
partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency
MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency
role of subunits in DNA helicase acdtivity
Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
MCM4 phosphorylation by Cdc7 (zeige CDC7 Proteine) kinase facilitates its interaction with Cdc45 (zeige CDC45 Proteine) on chromatin
Hypomorphic alleles of Mcm4 may increase breast cancer risk.
Loss of one allele of cdc2l (zeige CDK13 Proteine) genefacilitates carcinogen-induced skin carcinogenesis in vivo.
Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (zeige MCM2 Proteine) complex, causing impaired DNA replication and may have a causative role in cancer development.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
DNA replication licensing factor mcm4
, MCM4 minichromosome maintenance deficient 4
, minichromosome maintenance protein 4
, DNA replication licensing factor MCM4
, CDC21 homolog
, homolog of S. pombe cell devision cycle 21
, minichromosome maintenance deficient 4
, mini chromosome maintenance deficient 4 homolog
, minichromosome maintenance deficient 4 homolog