MCM4 Proteine (MCM4)

Bezeichnung:
Minichromosome Maintenance Deficient 4 Proteine (MCM4)
Auf www.antikoerper-online.de finden Sie aktuell 6 Minichromosome Maintenance Deficient 4 (MCM4) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MCM4 Antikörper (112) und MCM4 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 138 MCM4 Produkte verfügbar.
Synonyme:
19G, AI325074, AU045576, cb1025, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616
alle Proteine anzeigen Gen GeneID UniProt
MCM4 4173 P33991
Ratte MCM4 MCM4 29728  
MCM4 17217 P49717

Weitere Synonyme anzeigen

MCM4 Proteine (MCM4) nach Spezies

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Am meisten referenzierte MCM4 Proteine

  1. Human MCM4 Protein expressed in Wheat germ - ABIN1310553 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

Weitere Proteine zu MCM4 Interaktionspartnern

Human Minichromosome Maintenance Deficient 4 (MCM4) Interaktionspartner

  1. MCM4 and MCM7 (zeige MCM7 Proteine) expression is significantly correlated with Ki-67 (zeige MKI67 Proteine), Bmi1 (zeige BMI1 Proteine), and cyclin E (zeige CCNE1 Proteine) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.

  2. This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.

  3. We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin

  4. Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4

  5. Mutant p53 (zeige TP53 Proteine) depletion profoundly influenced PARP1 (zeige PARP1 Proteine) localization and increased the level of PCNA (zeige PCNA Proteine) and MCM4 proteins.

  6. Of the total, the deregulation of several genes (CDK1 (zeige CDK1 Proteine), CDK2 (zeige CDK2 Proteine), CDK4 (zeige CDK4 Proteine), MCM2 (zeige MCM2 Proteine), MCM3 (zeige MCM3 Proteine), MCM4, EIF3a (zeige EIF6 Proteine) and RPN2 (zeige PSMD1 Proteine)) were potentially associated with disease development and progression.

  7. Mcm2-7 (zeige MCM2 Proteine) loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.

  8. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells

  9. point mutation of MCM4 perturbs proper interaction with MCM6 (zeige MCM6 Proteine) to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 (zeige MCM2 Proteine) complex

  10. Mutations in MCM4/PRKDC (zeige PRKDC Proteine) represent a novel cause of DNA breakage and NK cell deficiency.

Mouse (Murine) Minichromosome Maintenance Deficient 4 (MCM4) Interaktionspartner

  1. Together, these data support a model in which chromosomal abnormalities in Sdl mice result from the ability of MCM4(D573H) to incorporate into MCM complexes and render them inactive.

  2. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells

  3. partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency

  4. MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency

  5. role of subunits in DNA helicase acdtivity

  6. Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.

  7. MCM4 phosphorylation by Cdc7 (zeige CDC7 Proteine) kinase facilitates its interaction with Cdc45 (zeige CDC45 Proteine) on chromatin

  8. Hypomorphic alleles of Mcm4 may increase breast cancer risk.

  9. Loss of one allele of cdc2l (zeige CDK13 Proteine) genefacilitates carcinogen-induced skin carcinogenesis in vivo.

  10. Mcm4(Chaos3) mutation appears to destabilize the MCM2-7 (zeige MCM2 Proteine) complex, causing impaired DNA replication and may have a causative role in cancer development.

MCM4 Protein Überblick

Protein Überblick

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Alternative names and synonyms associated with MCM4

  • minichromosome maintenance complex component 4 (mcm4)
  • MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) (mcm4)
  • minichromosome maintenance complex component 4 (MCM4)
  • minichromosome maintenance complex component 4 (Mcm4)
  • minichromosome maintenance deficient 4 homolog (S. cerevisiae) (Mcm4)
  • 19G Protein
  • AI325074 Protein
  • AU045576 Protein
  • cb1025 Protein
  • Cdc21 Protein
  • CDC54 Protein
  • fc12c09 Protein
  • fj85g09 Protein
  • hCdc21 Protein
  • hm:zeh1616 Protein
  • mcdc21 Protein
  • Mcmd4 Protein
  • mKIAA4003 Protein
  • NKCD Protein
  • NKGCD Protein
  • P1-CDC21 Protein
  • wu:fc12c09 Protein
  • wu:fj85g09 Protein
  • zeh1616 Protein

Bezeichner auf Proteinebene für MCM4

DNA replication licensing factor mcm4 , MCM4 minichromosome maintenance deficient 4 , minichromosome maintenance protein 4 , DNA replication licensing factor MCM4 , CDC21 homolog , homolog of S. pombe cell devision cycle 21 , minichromosome maintenance deficient 4 , mini chromosome maintenance deficient 4 homolog , minichromosome maintenance deficient 4 homolog , P1-CDC21

GENE ID SPEZIES
448137 Xenopus (Silurana) tropicalis
337598 Danio rerio
4173 Homo sapiens
426764 Gallus gallus
477871 Canis lupus familiaris
504367 Bos taurus
29728 Rattus norvegicus
17217 Mus musculus
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