anti-WAPAL (WAPAL) Antikörper

anti-Wings Apart-Like Protein Homolog Antikörper (WAPAL)
Auf finden Sie aktuell 27 Wings Apart-Like Protein Homolog (WAPAL) Antikörper von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 34 WAPAL Produkte verfügbar.
2410073G16, A530089A20Rik, BC037674, FOE, KIAA0261, mKIAA0261, mWAPL, RGD1308960, WAPL
Alle Antikörper anzeigen Gen GeneID UniProt
WAPAL 290577  
WAPAL 23063 Q7Z5K2
WAPAL 218914 Q65Z40

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Weitere Synonyme anzeigen

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anti-Rat (Rattus) WAPAL Antikörper:

anti-Human WAPAL Antikörper:

anti-Mouse (Murine) WAPAL Antikörper:

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Am meisten referenzierte anti-WAPAL Antikörper

  1. Human Polyclonal WAPAL Primary Antibody für ICC, IF - ABIN4365920 : Lu, Cui, Fu, Wang: Human wings apart-like gene is specifically overexpressed in cervical cancer. in Oncology letters 2016 (PubMed)

Weitere Antikörper gegen WAPAL Interaktionspartner

Human Wings Apart-Like Protein Homolog (WAPAL) Interaktionspartner

  1. Study shows that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged. Cohesin's DNA release factor WAPL restricts this loop extension and also prevents looping between incorrectly oriented CTCF (zeige CTCF Antikörper) sites.

  2. WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53 (zeige TP53 Antikörper)-dependent manner but causes p53 (zeige TP53 Antikörper)-deficient cells to become highly aneuploid.

  3. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin

  4. Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21 (zeige NSMCE2 Antikörper)-deficient or Scc1 (zeige PTPRJ Antikörper) mutant-expressing cells

  5. FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain.

  6. Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits

  7. Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin.

  8. our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability.

  9. isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder.

Mouse (Murine) Wings Apart-Like Protein Homolog (WAPAL) Interaktionspartner

  1. distribution of cohesin in the mouse genome depends on transcription, CTCF (zeige CTCF Antikörper) and the cohesin release factor Wings apart-like (Wapl)

  2. High levels of WAPAL are observed in human cervical cancers, and expression of human WAPAL in mice causes tumor formation.

  3. in mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus enabling mitotic exit in the presence of functional cohesin complexes

  4. mWAPL may be involved in spermatogenesis and be target genes mediating the reproductive toxicity induced by 2,3,7,8-trachlorodibenzo-p-dioxin .

WAPAL Antigen-Profil

Beschreibung des Gens

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).

Alternative names and synonyms associated with WAPAL

  • wings apart-like homolog (Drosophila) (Wapal) Antikörper
  • wings apart-like homolog (Drosophila) (WAPAL) Antikörper
  • wings apart-like protein homolog (LOC100408201) Antikörper
  • wings apart-like protein homolog (LOC100475548) Antikörper
  • wings apart-like homolog (Drosophila) (wapal) Antikörper
  • wings apart-like protein homolog (LOC100581674) Antikörper
  • 2410073G16 Antikörper
  • A530089A20Rik Antikörper
  • BC037674 Antikörper
  • FOE Antikörper
  • KIAA0261 Antikörper
  • mKIAA0261 Antikörper
  • mWAPL Antikörper
  • RGD1308960 Antikörper
  • WAPL Antikörper

Bezeichner auf Proteinebene für WAPAL

wings apart-like protein homolog , wings apart-like homolog (Drosophila) , WAPL family member (wapl-1)-like , friend of EBNA2 (Epstein-Barr virus nuclear protein 2) , friend of EBNA2 protein , DIF-2 , WAPL protein , dioxin-inducible factor 2 , friend of EBNA2

290577 Rattus norvegicus
423608 Gallus gallus
534322 Bos taurus
100408201 Callithrix jacchus
100452617 Pongo abelii
100475548 Ailuropoda melanoleuca
100546200 Meleagris gallopavo
100553268 Anolis carolinensis
100581674 Nomascus leucogenys
23063 Homo sapiens
218914 Mus musculus
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