TFAM Proteine (TFAM)

Bezeichnung:
Transcription Factor A, Mitochondrial Proteine (TFAM)
Auf www.antikoerper-online.de finden Sie aktuell 13 Transcription Factor A, Mitochondrial (TFAM) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TFAM Antikörper (145) und TFAM Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 181 TFAM Produkte verfügbar.
Synonyme:
AI661103, Hmgts, MGC153358, MTTF1, Mttfa, mttfa-A, TCF6, TCF6L1, TCF6L2, TCF6L3, tsHMG, xl-mtTFA, zgc:153358
alle Proteine anzeigen Gen GeneID UniProt
TFAM 7019 Q00059
TFAM 21780 P40630
TFAM 83474 Q91ZW1

Weitere Synonyme anzeigen

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Am meisten referenzierte TFAM Proteine

  1. Human TFAM Protein expressed in Escherichia coli (E. coli) - ABIN667339 : Aquilano, Vigilanza, Baldelli, Pagliei, Rotilio, Ciriolo: Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. in The Journal of biological chemistry 2010 (PubMed)
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Weitere Proteine zu TFAM Interaktionspartnern

Human Transcription Factor A, Mitochondrial (TFAM) Interaktionspartner

  1. In vivo, AICAR (zeige ATIC Proteine) significantly reduced osteosarcoma growth without apparent body weight loss and AICAR (zeige ATIC Proteine) increased both mitochondrial proliferation and apoptotic activity in treated tumor tissues. AICAR (zeige ATIC Proteine) showed anticancer effects in osteosarcoma cells through an AMPK (zeige PRKAA1 Proteine)-dependent peroxisome proliferatoractivated receptor-gamma coactivator-1alpha (PGC-1alpha)/mitochondrial transcription factor A (TFAM)/mitochondrial pathway

  2. the present study identified the interaction of miR (zeige MLXIP Proteine)-590-3p and TFAM in colon cancer. TFAM was identified as a target of miR (zeige MLXIP Proteine)-590-3p, and miR (zeige MLXIP Proteine)-590-3p enhanced the proliferation of SW480 cells.

  3. The results of the present study provided evidence that resistance to cisplatin chemotherapy in ERpositive breast cancer may be through TFAM and indicated that TFAM may be a target for chemoresistance in patients with breast cancer.

  4. miR (zeige MLXIP Proteine)-199a-3p is able to attenuate cisplatin resistance in breast cancer cells through inhibiting TFAM expression.

  5. We conducted a meta-analysis of studies involving CHAT, TFAM, and VR22 (zeige CTNNA3 Proteine) polymorphisms and Alzheimer disease susceptibility. For TFAM and VR22 (zeige CTNNA3 Proteine), no significant association was detected in studied single-nucleotide polymorphisms (SNPs).Rs1937 and rs2306604 of TFAM, are not significantly associated with AD risk.

  6. Results showed that TFAM formed oligomers in mitochondria by in situ chemical cross-linking and suggested the importance of the dimerization of TFAM molecules in the distribution of mtDNA in cells.

  7. Report failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers in skeletal muscle of chronic obstructive pulmonary disease patients.

  8. Data show that mtTFA proteins are highly expressed in cancer and drug-resistant cells compared to normal cells, and the mtTFA expression is upregulated by signals of oxidative and DNA damage stress in cancer cells. [review]

  9. TFAM overexpression suppressed mitoROS and their upregulation in rat cardiomyocytes.

  10. TFAM dimerization enhances mitochondrial DNA compaction by promoting looping of the DNA.

Pig (Porcine) Transcription Factor A, Mitochondrial (TFAM) Interaktionspartner

  1. TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.

Cow (Bovine) Transcription Factor A, Mitochondrial (TFAM) Interaktionspartner

  1. Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.

  2. de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (zeige NRF1 Proteine) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.

Mouse (Murine) Transcription Factor A, Mitochondrial (TFAM) Interaktionspartner

  1. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis.

  2. During muscle differentiation, Tfam protein levels are regulated by the availability of Tfam mRNA, which is controlled by both transcription and mRNA stability.

  3. TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.

  4. Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.

  5. There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.

  6. This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.

  7. Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (zeige TNF Proteine) release via RAGE (zeige AGER Proteine)- and TLR9 (zeige TLR9 Proteine)-responsive plasmacytoid dendritic cells.

  8. overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4 (zeige PID1 Proteine)-overexpressing adipocytes

  9. Acute exercise induces tumour suppressor protein p53 (zeige TP53 Proteine) translocation to the mitochondria and promotes a p53 (zeige TP53 Proteine)-Tfam-mitochondrial DNA complex in skeletal muscle.

  10. Data indicate that TFAM-deficient keratinocytes failed to generate mitochondria-derived reactive oxygen species, and prevented the transmission of Notch (zeige NOTCH1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) signals for epidermal differentiation and hair follicle development.

TFAM Protein Überblick

Protein Überblick

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with TFAM

  • transcription factor A, mitochondrial (TFAM)
  • transcription factor A, mitochondrial (tfam)
  • transcription factor A, mitochondrial (Tfam)
  • AI661103 Protein
  • Hmgts Protein
  • MGC153358 Protein
  • MTTF1 Protein
  • Mttfa Protein
  • mttfa-A Protein
  • TCF6 Protein
  • TCF6L1 Protein
  • TCF6L2 Protein
  • TCF6L3 Protein
  • tsHMG Protein
  • xl-mtTFA Protein
  • zgc:153358 Protein

Bezeichner auf Proteinebene für TFAM

transcription factor A, mitochondrial , HMG box mitochondrial transcription factor , mitochondrial transcription factor 1 , mitochondrial transcription factor A , transcription factor 6 , transcription factor 6-like 1 , transcription factor 6-like 2 (mitochondrial transcription factor) , transcription factor 6-like 3 , mtTFA , transcription factor 6-like 2 , TS-HMG , testis-specific HMG-box protein m-tsHMG , testis-specific high mobility group protein

GENE ID SPEZIES
373888 Gallus gallus
394385 Xenopus laevis
571106 Danio rerio
7019 Homo sapiens
488989 Canis lupus familiaris
397279 Sus scrofa
510059 Bos taurus
21780 Mus musculus
83474 Rattus norvegicus
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