anti-RAG2 (RAG2) Antikörper

anti-Recombination Activating Gene 2 Antikörper (RAG2)
Auf finden Sie aktuell 61 Recombination Activating Gene 2 (RAG2) Antikörper von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RAG2 Kits (24) und RAG2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 95 RAG2 Produkte verfügbar.
rag-2, zgc:136743

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Am meisten referenzierte anti-RAG2 Antikörper

  1. Human Monoclonal RAG2 Primary Antibody für WB - ABIN2666293 : Deriano, Chaumeil, Coussens, Multani, Chou, Alekseyenko, Chang, Skok, Roth: The RAG2 C terminus suppresses genomic instability and lymphomagenesis. in Nature 2011 (PubMed)
    Zeige alle 6 Referenzen für 2666293

  2. Human Monoclonal RAG2 Primary Antibody für ELISA, WB - ABIN969379 : Nagawa, Hirose, Nishizumi, Nishihara, Sakano: Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA. in The Journal of biological chemistry 2004 (PubMed)

Weitere Antikörper gegen RAG2 Interaktionspartner

Human Recombination Activating Gene 2 (RAG2) Interaktionspartner

  1. This study reports on the prevalence of RAG1 (zeige RAG1 Antikörper) and RAG2 mutations in ten severe combined immunodeficiency (zeige PRKDC Antikörper) disorder patients in Egypt.

  2. analysis of regions of RAG1 (zeige RAG1 Antikörper) necessary for interaction with RAG2 and measurement of the RAG1 (zeige RAG1 Antikörper)-RAG2 binding affinity

  3. DNA damage triggers relocalization of RAG2 from the nucleus to centrosomes, suggesting a novel mechanism for modulating cellular responses to double strand breaks in developing lymphocytes.

  4. found that Ikaros (zeige IKZF1 Antikörper), a lymphocyte-specific transcription factor, acts as a repressor of NWC promoter--thus identifying a new Ikaros (zeige IKZF1 Antikörper) target--but is insufficient for inducing methylation which depends on the antisense transcription driven by RAG-2 promoter

  5. Investigate the factors that regulate RAG1 (zeige RAG1 Antikörper) and RAG2 cleavage on non-B DNA structures. We find that RAG binding and cleavage on heteroduplex DNA is dependent on the length of the double-stranded flanking region.

  6. The results indicate that the contribution of immune dysregulatory disease due to RAG2 mutations present in the general population may be much higher than previously estimated.

  7. The major B cell isoform, BCL11A-XL (zeige BCL11A Antikörper), binds the RAG1 (zeige RAG1 Antikörper) promoter and Erag enhancer to activate RAG1 (zeige RAG1 Antikörper) and RAG2 transcription in pre-B cells.

  8. Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells

  9. A novel homozygous mutation with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome

  10. analysis of multiorgan metastasis of human HER-2 (zeige ERBB2 Antikörper)+ breast cancer in Rag2-/-;Il2rg (zeige IL2RG Antikörper)-/- mice and treatment with PI3K (zeige PIK3CA Antikörper) inhibitor

Mouse (Murine) Recombination Activating Gene 2 (RAG2) Interaktionspartner

  1. This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (zeige AKAP17A Antikörper) development to prevent mistimed dsDNA breaks and their deleterious consequences.

  2. a novel RAG1 (zeige RAG1 Antikörper)/2-mediated insertion pathway distinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and shares features with reported oncogenic DNA insertions.

  3. loss of the BH3-only (zeige BBC3 Antikörper) protein BIM (zeige BCL2L11 Antikörper) accelerated lymphoma development in p53 (zeige TP53 Antikörper)-deficient mice. This process was negated by concomitant loss of RAG1 (zeige RAG1 Antikörper)/2-mediated antigen receptor gene rearrangement.

  4. the zinc finger motif within the noncore region of RAG2 is indispensable for maintaining the stability of the RAG2 protein.

  5. evolution of RAG1 (zeige RAG1 Antikörper)/RAG2 began with a Transib transposon whose intrinsic recombination activity was enhanced by capture of an ancestral RAG2, allowing for the development of adaptive immunity.

  6. Rag2(R229Q) knock-in mice developed an inflammatory bowel disease affecting both the small bowel and colon.

  7. Rag2 truncation substantially increased the frequency of off-target V(D)J recombination. The data suggest that interactions between Rag2 and a specific chromatin modification, H3K4me3, support V(D)J recombination fidelity.

  8. These results reveal an unanticipated functional interplay between the RAG complex and XLF (zeige NHEJ1 Antikörper) in repairing RAG-induced DNA breaks and maintaining genome integrity during antigen receptor gene assembly.

  9. Based on our results, we propose that interaction of RAG2 with RAG1 (zeige RAG1 Antikörper) induces cooperative interactions of multiple binding sites, induced through conformational changes at the RAG1 (zeige RAG1 Antikörper) interdomain boundary

  10. 12recombination signal sequences-23recombination signal sequences cooperation (the "12/23 rule") is important not only for regulating RAG-mediated DNA cleavage but also for the efficiency of RAG1 (zeige RAG1 Antikörper) and RAG2 recruitment to chromatin.

Pig (Porcine) Recombination Activating Gene 2 (RAG2) Interaktionspartner

  1. Produced RAG2-knockouts via somatic cell nuclear transfer and analyzed their phenotype. The V(D)J recombination processes were confirmed as being inactivated. They consistently lacked mature T and B cells but had substantial numbers of cells considered to be T- or B-cell progenitors as well as NK cells. They also lacked thymic medulla and lymphoid aggregations in the spleen, mesenteric lymph nodes, and Peyer's patches.

  2. Homozygous RAG1 (zeige RAG1 Antikörper)/2 knockout pigs lack mature B and T lymphocytes; recombination does not occur in the Ig heavy chain (IgH) locus of RAG1 (zeige RAG1 Antikörper)- and RAG2-deficient pigs.

Zebrafish Recombination Activating Gene 2 (RAG2) Interaktionspartner

  1. created rag2(E450fs) mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund

RAG2 Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Alternative names and synonyms associated with RAG2

  • recombination activating gene 2 (RAG2) Antikörper
  • recombination activating gene 2 (Rag2) Antikörper
  • recombination activating gene 2 (rag2) Antikörper
  • rag-2 Antikörper
  • zgc:136743 Antikörper

Bezeichner auf Proteinebene für RAG2

recombination activating gene 2 , recombination activating protein 2 , V(D)J recombination-activating protein 2-like , V(D)J recombination-activating protein 2 , recombinase activating gene 2 , v(D)J recombination-activating protein 2 , RAG-2

466490 Pan troglodytes
493757 Felis catus
716837 Macaca mulatta
100396079 Callithrix jacchus
100447476 Pongo abelii
100596220 Nomascus leucogenys
5897 Homo sapiens
19374 Mus musculus
295953 Rattus norvegicus
100328951 Oryctolagus cuniculus
100723894 Cavia porcellus
100151744 Sus scrofa
423165 Gallus gallus
483419 Canis lupus familiaris
782387 Bos taurus
30658 Danio rerio
100037211 Xenopus laevis
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