MYSM1 Proteine (MYSM1)

Auf finden Sie aktuell 4 Myb-Like, SWIRM and MPN Domains 1 (MYSM1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MYSM1 Antikörper (64) und MYSM1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 75 MYSM1 Produkte verfügbar.
2A-DUB, 2adub, C130067A03Rik, C530050H10Rik, RGD1311787, RP4-592A1.1
alle Proteine anzeigen Gen GeneID UniProt
MYSM1 114803 Q5VVJ2
MYSM1 320713 Q69Z66
Ratte MYSM1 MYSM1 298247  

MYSM1 Proteine (MYSM1) nach Spezies

Weitere Proteine zu MYSM1 Interaktionspartnern

Human Myb-Like, SWIRM and MPN Domains 1 (MYSM1) Interaktionspartner

  1. data suggested that expression of MYSM1 was associated with the progression of CRC (zeige CALR Proteine) and might be a potential biomarker for clinical prognosis

  2. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation

  3. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings

  4. The SWIRM structure of human MYb (zeige MYB Proteine)-like, Swirm and Mpn domain-containing protein (zeige MPND Proteine)-1 (MYSM1), is reported.

  5. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported.

Mouse (Murine) Myb-Like, SWIRM and MPN Domains 1 (MYSM1) Interaktionspartner

  1. Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.

  2. MYSM1 activity at the prepro-B cell stage of development is important for the normal programming of B cell responses to stimulation once they complete their maturation process.

  3. Overall we conclude that Mysm1 expression within the niche is not essential for the maintenance of hematopoietic homeostasis.

  4. this study shows that MYSM1 is involved in the maintenance, activation and survival of CD8 (zeige CD8A Proteine)+ T cells

  5. The results demonstrate that MYSM1 plays a critical role in Mesenchymal Stromal Cell maintenance and differentiation. This study also underscores the biological significance of deubiquitinase activity in Mesenchymal Stromal Cell function.

  6. MYSM1 is a critical negative regulator of p53 (zeige TP53 Proteine) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA (zeige BBC3 Proteine) expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cell function

  7. this study uncovers a critical role for MYSM1 in epigenetically repressing plasma cell differentiation and antibody production, in addition to its opposing, active role in B cell development.

  8. MYSM1 is essential for normal HSC (zeige FUT1 Proteine) function and progression of hematopoiesis in the fetal liver and HSC (zeige FUT1 Proteine) maintenance in adult bone marrow.

  9. 2 motifs in MYSM1 are essential for innate immune suppression: the SWIRM domain that interacts with TRAF3 (zeige TRAF3 Proteine) and TRAF6 (zeige TRAF6 Proteine) and the metalloproteinase domain that removed K63 polyubiquitins. MYSM1 is a key negative regulator of the innate immune system

  10. Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 (zeige TP53 Proteine) activation.

MYSM1 Protein Überblick

Protein Überblick

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).

Alternative names and synonyms associated with MYSM1

  • Myb-like, SWIRM and MPN domains 1 (MYSM1)
  • myb-like, SWIRM and MPN domains 1 (Mysm1)
  • myb-like, SWIRM and MPN domains 1 (MYSM1)
  • myb-like, SWIRM and MPN domains 1 (mysm1)
  • 2A-DUB Protein
  • 2adub Protein
  • C130067A03Rik Protein
  • C530050H10Rik Protein
  • RGD1311787 Protein
  • RP4-592A1.1 Protein

Bezeichner auf Proteinebene für MYSM1

histone H2A deubiquitinase MYSM1 , myb-like, SWIRM and MPN domain-containing protein 1 , 2A-DUB , Myb-like, SWIRM and MPN domain-containing protein 1

114803 Homo sapiens
320713 Mus musculus
298247 Rattus norvegicus
424671 Gallus gallus
779416 Xenopus laevis
Ausgewählte Anbieter für MYSM1 Proteine (MYSM1)
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