anti-HELLS (HELLS) Antikörper

anti-Helicase, Lymphoid-Specific Antikörper (HELLS)
Auf finden Sie aktuell 60 Helicase, Lymphoid-Specific (HELLS) Antikörper von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HELLS Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 72 HELLS Produkte verfügbar.
AI323785, cb65, E130115I21Rik, HELLS, im:6911667, lsh, Lysh, nbla10143, PASG, sb:cb65, sb:cb749, smarca6, Tbc1d12, YFK8
Alle Antikörper anzeigen Gen GeneID UniProt
HELLS 15201 Q60848
HELLS 294071  

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Meistgesuchte Reaktivitäten zu anti-HELLS (HELLS) Antikörper

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anti-Mouse (Murine) HELLS Antikörper:

anti-Rat (Rattus) HELLS Antikörper:

anti-Human HELLS Antikörper:

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Am meisten referenzierte anti-HELLS Antikörper

  1. Human Monoclonal HELLS Primary Antibody für WB - ABIN394178 : Zhou, Han, Li, Tong: Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts. in Nucleic acids research 2009 (PubMed)
    Zeige alle 5 Referenzen für 394178

  2. Cow (Bovine) Polyclonal HELLS Primary Antibody für WB - ABIN2775238 : Myant, Stancheva: LSH cooperates with DNA methyltransferases to repress transcription. in Molecular and cellular biology 2007 (PubMed)

Weitere Antikörper gegen HELLS Interaktionspartner

Zebrafish Helicase, Lymphoid-Specific (HELLS) Interaktionspartner

  1. Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1 (zeige DNMT1 Antikörper).

Mouse (Murine) Helicase, Lymphoid-Specific (HELLS) Interaktionspartner

  1. fibroblasts derived from chromatin remodeling ATPase (zeige DNAH8 Antikörper) LSH (HELLS)-null mouse embryos, which lack DNA methylation from centromeric repeats, transposons and a number of gene promoters, are capable of reestablishing DNA methylation and silencing of misregulated genes upon re-expression of LSH.

  2. Data suggest that HELLS controls cytosine methylation in a nuclear compartment that is in part defined by lamin B1 (zeige LMNB1 Antikörper) attachment regions.

  3. histone H3 (zeige HIST3H3 Antikörper) lysine 4 methylation modification was assessed in murine embryonic fibroblasts (MEFs) derived from the DNA methylation mutant Lsh(-/-) mice.

  4. These results indicate that in the absence of HELLS, proliferation of spermatogonia is reduced and germ cell differentiation arrested at the midpachytene stage, implicating an essential role for HELLS during male meiosis.

  5. LSH is essential for developmentally programmed de novo DNA methylation at the promoters of protein coding genes and recruitment of G9a (zeige EHMT2 Antikörper)/GLP (zeige GOLGA6A Antikörper) complex to a subset of genomic loci.

  6. Data show that hypomethylation in Lsh-/- cells is associated with efficient transcriptional elongation and splicing.

  7. model in which Lsh is recruited by intact heterochromatin structure and then assists in maintaining heterochromatin organization by establishing CpG methylation patterns

  8. PASG mutant mice display signs of growth retardation and premature aging, including low birth weight, failure to thrive, graying and loss of hair, reduced skin fat deposition, osteoporosis, kyphosis, cachexia, and premature death.

  9. Lsh has a critical and previously unidentified role in epigenetic gene silencing and maintenance of genomic stability during female meiosis.

  10. Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of polycomb (zeige CBX2 Antikörper) repressive complex targets

Human Helicase, Lymphoid-Specific (HELLS) Interaktionspartner

  1. LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH (zeige FH Antikörper)).

  2. Mutations in HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome type 4.

  3. Mutations of HELLS gene is associated with stomach and colorectal cancers.

  4. Upregulation of HELLS and UHRF1 (zeige UHRF1 Antikörper) is essential for the tumor phenotype. Also, these epigenetic regulators are important for the regulation of SYK (zeige SYK Antikörper).

  5. just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours

  6. E2F1 (zeige E2F1 Antikörper) plays a crucial role in transcriptional control of the human Lsh gene and the decrease of Lsh expression in senescent cells is related to the repression of E2F1 (zeige E2F1 Antikörper)

  7. Data provide strong evidence that CEP55 (zeige CEP55 Antikörper) and HELLS may be used in conjunction with FOXM1 (zeige FOXM1 Antikörper) as a biomarker set for early cancer detection and indicators of malignant conversion and progression.

  8. LSH serves as a recruiting factor for DNA methyltransferases and histone deacetylases to establish transcriptionally repressive chromatin which is perhaps further stabilized by DNA methylation at targeted loci

  9. These results suggest differences in cellular consequences of hypomethylation mediated by PASG during development compared to that in somatic cells.

  10. Lsh overexpression delays cell senescence by silencing p16(INK4a (zeige CDKN2A Antikörper)) in human fibroblasts.

Xenopus laevis Helicase, Lymphoid-Specific (HELLS) Interaktionspartner

  1. Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1 (zeige DNMT1 Antikörper).

HELLS Antigen-Profil

Beschreibung des Gens

This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with HELLS

  • helicase, lymphoid-specific (HELLS) Antikörper
  • helicase, lymphoid-specific (hells) Antikörper
  • helicase, lymphoid specific (Hells) Antikörper
  • AI323785 Antikörper
  • cb65 Antikörper
  • E130115I21Rik Antikörper
  • HELLS Antikörper
  • im:6911667 Antikörper
  • lsh Antikörper
  • Lysh Antikörper
  • nbla10143 Antikörper
  • PASG Antikörper
  • sb:cb65 Antikörper
  • sb:cb749 Antikörper
  • smarca6 Antikörper
  • Tbc1d12 Antikörper
  • YFK8 Antikörper

Bezeichner auf Proteinebene für HELLS

helicase, lymphoid-specific , helicase, lymphoid specific , lymphoid-specific helicase-like , lymphocyte-specific helicase , proliferation-associated SNF2-like protein , TBC1D12: TBC1 domain family, member 12 , SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6 , SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6 , lymphoid-specific helicase

423750 Gallus gallus
450624 Pan troglodytes
553328 Danio rerio
701598 Macaca mulatta
100061642 Equus caballus
100216265 Xenopus (Silurana) tropicalis
100387530 Callithrix jacchus
100544292 Meleagris gallopavo
100566701 Anolis carolinensis
100601099 Nomascus leucogenys
15201 Mus musculus
294071 Rattus norvegicus
3070 Homo sapiens
446222 Xenopus laevis
486809 Canis lupus familiaris
100154547 Sus scrofa
540933 Bos taurus
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