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These results demonstrate that the alcohol- induced increase in hepatic Pde4 (zeige PDE4A Proteine), specifically Pde4b expression, and compromised cAMP signalling predispose the liver to impaired fatty acid oxidation and the development of steatosis.
PDE4B phosphorylated by AMPK (zeige PRKAA1 Proteine) at Ser304 is important for activation.
Lymphomas developing in a Pde4b-null background display significantly lower microvessel density in association with lower VEGF (zeige VEGFA Proteine) levels and PI3K/AKT (zeige AKT1 Proteine) activity.
Genetic variations in DISC1 influence formation of biochemical complex with PDE4 and GSK-3 and strengthen the possibility of synergistic interactions between these proteins.
PDE4B-deficient mice display impaired reversal learning in the Morris water maze compared to wild-type littermates.
Results identify PDE4B in the CaV1.2 (zeige CACNA1C Proteine) complex as a critical regulator of ICa during beta-AR stimulation and suggest that distinct PDE4 (zeige PDE4A Proteine) subtypes are important for normal regulation of calcium-induced calcium release in cardiomyocytes.
Findings demonstrate that PDE4D (zeige PDE4D Proteine) and PDE4B have specialized functions in mouse embryonic fibroblasts with PDE4B controlling cAMP in a discrete subdomain near the plasma membrane.
induction is esssential for LPS (zeige TLR4 Proteine)-activated tnf-alpha (zeige TNF Proteine) responses
PDE4B mediates the antipsychotic effects of rolipram in conditioned avoidance responding; the PDE4B-regulated cyclic adenosine monophosphate signaling pathway may play a role in the pathophysiology and pharmacotherapy of psychosis
the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior.
contains four isoforms expressed from the same gene\; isoform Pde4b4 has cAMP specific phosphdiesterase activity and is inhibited by rolipram
phosphodiesterase 4B, cAMP-specific a
, phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
, phosphodiesterase 4B
, 3',5'-cyclic AMP phosphodiesterase
, Phosphodiesterase 4B cAMP-specific (dunce
, Phosphodiesterase 4B, cAMP-specific (dunce
, cAMP-specific 3',5'-cyclic phosphodiesterase 4B